Covid-19 and Pregnancy: An Overview

Castro, Pedro; Matos, Ana Paula; Werner, Heron; Lopes, Flávia Paiva; Tonni, Gabriele; Araujo Júnior, Edward

doi:10.1055/s-0040-1713408

Pedro Castro

Department of Fetal Medicine, Clínica de Diagnóstico por Imagem, Rio de Janeiro, RJ, Brazil

Department of Radiology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0001-8204-7264

Ana Paula Matos

Department of Fetal Medicine, Clínica de Diagnóstico por Imagem, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0002-3639-2259

Heron Werner

Department of Fetal Medicine, Clínica de Diagnóstico por Imagem, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0002-8620-7293

Flávia Paiva Lopes

Department of Fetal Medicine, Clínica de Diagnóstico por Imagem, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0002-6713-4041

Gabriele Tonni

Prenatal Diagnostic Service, Department of Obstetrics and Gynecology, AUSL Reggio Emilia, Italy

https://orcid.org/0000-0002-2620-7486

Edward Araujo Júnior

Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil

Medical Course, Universidade Municipal de São Caetano do Sul, São Caetano do Sul, SP, Brazil

https://orcid.org/0000-0002-6145-2532

Address for correspondence Edward Araujo Júnior, PhD, Rua Botucatu, 740, 04023-062, Vila Clementino, São Paulo, SP, Brazil (e-mail: araujojred@terra.com.br).

Conflict of Interests

The authors have no conflict of interests to declare.

	Cases	Maternal Age (years old)	Gestational age at clinical manifestation (weeks)	Gestational age at delivery	Methods of Diagnosis	Delivery Mode	Birthweight (grams)
Chen et al²⁹29 Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-815. Doi: 10.1016/S0140-6736(20)30360-3 https://doi.org/10.1016/S0140-6736(20)30...	9	28 (26–40)	37⁺² (36–39⁺⁴)	37⁺²	qRT-PCR	9 CS	2970 (1880–3820)
Zhu et al⁵³53 Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(01):51-60. Doi: 10.21037/ tp.2020.02.06 https://doi.org/10.21037/...	7	30 (25–34)	34⁺⁵ (30⁺⁴-38⁺⁴)	34⁺⁶	CT	6 CS 1 VD	2300 (1520–3800)
Liu et al²⁷27 Liu D, Li L,Wu X, Zheng D,Wang J, Yang L, Zheng C. Pregnancy and perinatal outcomes of women with Coronavirus Disease (COVID- 19) pneumonia: a preliminary analysis. AJR Am J Roentgenol. 2020;•••:1-6. Doi: 10.2214/AJR.20.23072 https://doi.org/10.2214/AJR.20.23072... ^* * data including three puerperal patients.	11	32 (23–40)	2–19 days before admission at 32w (12–38)	NA	CT	10 CS 1 VD	NA
Yu et al³⁷37 Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(05):559-564. Doi: 10.1016/S1473-3099(20)30176-6 https://doi.org/10.1016/S1473-3099(20)30...	7	32 (29–34)	5 days (2–9) before admission at 39w (37–41)	39⁺²(37–41⁺⁵)	qRT-PCR and CT	7 CS	3250 (3000–3500)
Chen et al⁴⁰40 Chen S, Liao E, Cao D, Gao Y, Sun G, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. J Med Virol. 2020;•••;. Doi: 10.1002/jmv.25789 https://doi.org/10.1002/jmv.25789...	5	29 (25–31)	39⁺¹ (38⁺⁶-40⁺³)	39⁺¹ (38⁺⁶-40⁺⁴)	qRT-PCR	2 CS 3 VD	3700 (3235–4050)
Lee et al³⁸38 Lee DH, Lee J, Kim E, Woo K, Park HY, An J. Emergency cesarean section on severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) confirmed patient. Korean J Anesthesiol. 2020; •••;. Doi: 10.4097/kja.20116 https://doi.org/10.4097/kja.20116...	1	28	36⁺²	37⁺⁶	qRT-PCR	CD	3130
Liu et al⁵⁴54 Liu Y, Chen H, Tang K, Guo Y. Clinicalmanifestations and outcome of SARS-CoV-2 infection during pregnancy. J Infect. 2020; pii: S0163-4453(20)30109-2. . Doi: 10.1016/j.jinf.2020.02.028 https://doi.org/10.1016/j.jinf.2020.02.0...	13	22–36	2 days before 28 weeks and 11 days on third trimester	NA	qRT-PCR	10 CD (100%)	NA

	Cases	Fever	Cough	Sore throat	Diarrhea	Dyspnea
Chen et al²⁹29 Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-815. Doi: 10.1016/S0140-6736(20)30360-3 https://doi.org/10.1016/S0140-6736(20)30...	9	78%	44%	22%	11%	11%
Zhu et al⁵³53 Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(01):51-60. Doi: 10.21037/ tp.2020.02.06 https://doi.org/10.21037/...	7	100%	42%	14%	14%	NA
Liu et al²⁷27 Liu D, Li L,Wu X, Zheng D,Wang J, Yang L, Zheng C. Pregnancy and perinatal outcomes of women with Coronavirus Disease (COVID- 19) pneumonia: a preliminary analysis. AJR Am J Roentgenol. 2020;•••:1-6. Doi: 10.2214/AJR.20.23072 https://doi.org/10.2214/AJR.20.23072... ^* * data including three puerperal patients.	11	86%	59%	6%	6%	6%
Yu et al³⁷37 Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(05):559-564. Doi: 10.1016/S1473-3099(20)30176-6 https://doi.org/10.1016/S1473-3099(20)30...	7	85%	14%	NA	14%	14%
Chen et al⁴⁰40 Chen S, Liao E, Cao D, Gao Y, Sun G, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. J Med Virol. 2020;•••;. Doi: 10.1002/jmv.25789 https://doi.org/10.1002/jmv.25789...	5	0%	0%	NA	NA	0%
Lee et al³⁸38 Lee DH, Lee J, Kim E, Woo K, Park HY, An J. Emergency cesarean section on severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) confirmed patient. Korean J Anesthesiol. 2020; •••;. Doi: 10.4097/kja.20116 https://doi.org/10.4097/kja.20116...	1	Present	Present	Present	NA	NA
Liu et al⁵⁴54 Liu Y, Chen H, Tang K, Guo Y. Clinicalmanifestations and outcome of SARS-CoV-2 infection during pregnancy. J Infect. 2020; pii: S0163-4453(20)30109-2. . Doi: 10.1016/j.jinf.2020.02.028 https://doi.org/10.1016/j.jinf.2020.02.0...	13	77%	NA	NA	NA	23%

[1] Address for correspondence Edward Araujo Júnior, PhD, Rua Botucatu, 740, 04023-062, Vila Clementino, São Paulo, SP, Brazil (e-mail: araujojred@terra.com.br).

Brasil

Brasil

Covid-19 and Pregnancy: An Overview

Covid-19 e gravidez: Uma visão geral

Abstract