ABSTRACT
Introduction:
In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields.
Objective:
We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports.
Methods:
We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing.
Results:
In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage.
Conclusion:
Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.
Keywords:
Sports; Bone Morphogenetic Protein 1; Gene therapy