PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT

O EXERCÍCIO FÍSICO NA PROMOÇÃO DE EFEITOS AUXILIARES DA TERAPIA GENÉTICA

EL EJERCICIO FÍSICO EN LA PROMOCIÓN DE EFECTOS AUXILIARES DE LA TERAPIA GENÉTICA

ABSTRACT

Introduction:

In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields.

Objective:

We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports.

Methods:

We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing.

Results:

In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage.

Conclusion:

Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.

Keywords:
Sports; Bone Morphogenetic Protein 1; Gene therapy