EFECTO DEL EJERCICIO EN CINTA DE CORRER DE INTENSIDAD MODERADA SOBRE EL AUMENTO DE LOS NIVELES DE ADIPONECTINA EN PACIENTES CON DIABETES MELLITUS TIPO 2 PSİCOLÓGİCA

Mudjanarko, Sony Wibisono; Irawati, Anugrahini; Tinduh, Damayanti; Susanto, Tsana Nadhira

doi:10.1590/1517-8692202329022022_0144i

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Original Article, Medical Clinic • Rev Bras Med Esporte 29 • 2023 • https://doi.org/10.1590/1517-8692202329022022_0144i linkcopiar

EFECTO DEL EJERCICIO EN CINTA DE CORRER DE INTENSIDAD MODERADA SOBRE EL AUMENTO DE LOS NIVELES DE ADIPONECTINA EN PACIENTES CON DIABETES MELLITUS TIPO 2 PSİCOLÓGİCA

Autoría SCIMAGO INSTITUTIONS RANKINGS

RESUMEN

Introducción: La adiponectina desempeña un papel importante en el sistema metabólico al inhibir las citoquinas proinflamatorias y al utilizar la captación de glucosa. La cinta de correr es un dispositivo de caminata aeróbica que estimula las características de la marcha natural. Los ejercicios aumentan el nivel de adiponectina, lo que se traduce en una mayor sensibilidad a la insulina.

Objetivos: Analizar el efecto de los ejercicios aeróbicos en una cinta de correr de intensidad moderada con un aumento gradual de la velocidad y la inclinación sobre los niveles de adiponectina en hombres con diabetes mellitus tipo 2 (DMT2).

Método: Veintidós participantes con DMT2 fueron asignados aleatoriamente a grupos de ejercicio en cinta de correr y de control. El grupo experimental realizó sesiones de ejercicio en cinta de correr de 30 minutos de intensidad moderada con velocidad creciente e inclinación gradual tres veces por semana durante cuatro semanas. El grupo de control se sometió a ejercicios individuales durante 150 minutos a la semana. Se evaluaron los parámetros clínicos y de laboratorio de los participantes antes y después del programa de cuatro semanas.

Resultados: Hubo un aumento significativo del nivel de adiponectina de 456,3 ± 42 pg/ml a 586,3 ± 87,8 pg/ml (p=0,04, p<0,05) en el grupo de ejercicio en cinta de correr. En el grupo de control, la adiponectina presentó un pequeño aumento de 466,7 ± 85 pg/ml a 471,8 ± 59 pg/ml (p=0,646).

Conclusión: Se descubrió que los ejercicios en cinta de correr de intensidad moderada con velocidad creciente e inclinación gradual conducen a un resultado significativamente superior en la mejora de los niveles de adiponectina en comparación con los ejercicios individuales estándar en el tratamiento de la DMT2. Nivel de evidencia II; Estudios terapéuticos – Investigación de resultados del tratamiento.

Descriptores: Adiponectina; Ejercicio; Prueba ergométrica de bicicleta; Diabetes mellitus tipo 2

	Treadmill Exercise Group (n= 10)	Control Group (n=10)	P value
Age, years (Mean ± SD)	50.7 ± 4.5	46.1 ± 3.8	0.017 ^X X Mann-Whitney U test was used to determine the differences between groups for age, duration of DM, systolic pressure, fasting glucose, and adiponectin level; ^* * p-value of <0.05 was found significant;
Duration of DM, years (Mean ± SD)	5.5 ± 4.7	4.5 ± 4.7	0.361 ^X X Mann-Whitney U test was used to determine the differences between groups for age, duration of DM, systolic pressure, fasting glucose, and adiponectin level;
Body Mass Index (kg/m²)	23.9 ± 3.6	26.7 ± 4.4	0.141^Y Y Independent Sample T-Test was used to determine the differences between groups for BMI, HbA1c, and random glucose;
HbA1c (%)	6.5 ± 1.2	7.9 ± 2.1	0.09^Y Y Independent Sample T-Test was used to determine the differences between groups for BMI, HbA1c, and random glucose;
Random Glucose (mg/dL)	180.7 ± 50.4	159.3 ± 3	0.272^Y Y Independent Sample T-Test was used to determine the differences between groups for BMI, HbA1c, and random glucose;
Systolic pressure (mmHg)	116 ± 7	114 ± 7	0.435 ^X X Mann-Whitney U test was used to determine the differences between groups for age, duration of DM, systolic pressure, fasting glucose, and adiponectin level;
Fasting Glucose (mg/dL)	123 ± 71.8	110.6 ± 20.7	0.226 ^X X Mann-Whitney U test was used to determine the differences between groups for age, duration of DM, systolic pressure, fasting glucose, and adiponectin level;
Adiponectin (pg/ml)	456.3 ± 42	466.7 ± 85	0.597 ^X X Mann-Whitney U test was used to determine the differences between groups for age, duration of DM, systolic pressure, fasting glucose, and adiponectin level;
Clinical Characteristic
Insulin Use, n (%)	4 (40)	2 (20)	0.628^Z Z Pearson Chi-Square (χ2) test was used to determine the differences between groups for the history of insulin use, dyslipidemia, and hypertension.
Dyslipidemia, n (%)	2 (20)	2 (20)	1.000^Z Z Pearson Chi-Square (χ2) test was used to determine the differences between groups for the history of insulin use, dyslipidemia, and hypertension.
Hypertension, n (%)	4 (40)	2 (20)	0.628^Z Z Pearson Chi-Square (χ2) test was used to determine the differences between groups for the history of insulin use, dyslipidemia, and hypertension.

Adiponectin level (pg/ml)	Treadmill Exercise Group (n= 10)	Control Group (n=10)	p-value
Before exercise	456.3 ± 42	466.7 ± 85	0.597 ^X X Mann-Whitney U test
After exercise	586.3 ± 87.8	471.8 ± 59	0.03 ^Y Y Independent Sample T-Test
Mean difference before and after exercise (p-value)	0.004 ^A A Paired T-Test ^* * p-value of <0.05 was found significant;	0.646 ^B B Wilcoxon-signed Rank Test	-
∆Adiponectin	129.9 ± 108.5	5.08 ± 104.6	0.017^Y Y Independent Sample T-Test

		Treadmill Exercise Group (n= 10)	Control Group (n=10)	p value
BMI (kg/m ²)	Before exercise	23,9 ± 3,6	26,7 ± 4,4	0,141 ^Y Y Independent Sample T-Test
	After exercise	24,9 ± 4	27,4 ± 5,3	0,25 ^Y Y Independent Sample T-Test
	Mean Difference (p value)	0,21 ^A A Paired T-Test	0,128 ^A A Paired T-Test	-
FPG (mg/dL)	Before exercise	123 ± 71,8	110,6 ± 20,7	0,226 ^X X Mann-Whitney U test
	After exercise	99,5 ± 41	77,3 ± 19,5	0,18 ^Y Y Independent Sample T-Test
	Mean Difference (p value)	0,386 ^B B Wilcoxon-signed Rank Test	0,022 ^A A Paired T-Test	-

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[TFN1] ^*
p-value of <0.05 was found significant;

[TFN1a] ^X
Mann-Whitney U test was used to determine the differences between groups for age, duration of DM, systolic pressure, fasting glucose, and adiponectin level;

[TFN1b] ^Y
Independent Sample T-Test was used to determine the differences between groups for BMI, HbA1c, and random glucose;

[TFN1c] ^Z
Pearson Chi-Square (χ²) test was used to determine the differences between groups for the history of insulin use, dyslipidemia, and hypertension.