Evaluation of tear film function, ocular surface and tear film in HIV-seropositive patients

Mosena, Carolina Ramos; Pinheiro, Marcus Vinicius Vieira; Alhadeff, Paula Azevedo; Neiva, Thyarles Tomich; Felberg, Sérgio

doi:10.5935/0034-7280.20150019

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• Rev. bras. oftalmol. 74 (2) • Mar-Apr 2015 • https://doi.org/10.5935/0034-7280.20150019 copy

Evaluation of tear film function, ocular surface and tear film in HIV-seropositive patients

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

Evaluate tear function, tear film and ocular surface in patients with positive serology for HIV.

Methods:

Observational, cross-sectional, quantitative and analytical study, performed between june and october 2011, in the HSPE-SP Ophthalmology Department, including 32 patients. Sixteen were HIV-positive patients and 16 HIV-negative.

Results:

There was no significant statistical difference in the middle age between both groups (p=0.083). The ferning test was statistically different in HIV group (with predominance of III and IV) compared to the control group (in which predominated the patterns I and II), both in the right and the left eye (p = 0.019 and p < 0.001, respectively). Other parameters were not statistically significant between the groups.

Conclusions:

HIV-positive patients had no changes in lacrimal function and ocular surface, however, samples of tears showed differences considered statistically significant in the crystallization test, compared with samples obtained from controls.

keratoconjunctivitis sicca; HIV; Dry eye

	Group
Variable	Control		HIV+		Total		p-Value
	n	%	n	%	N	%
Gender							> 0.999#
Female	11	68.8	11	68.8	22	68.8
Male	5	31.3	5	31.3	10	31.3
Total	16	100	16	100	32	100

Variable	Group Average SD			Mean	Min	Max	N	p-Value
Age	Control	55.50	20.81	55.5	18	85	16	0.083
(years)	HIV+	44.94	10.33	44	18	72	16

Patient	Gender	Age	Δt Infection
1	F	46	132
2	M	41	7
3	F	44	96
4	M	43	96
5	M	41	120
6	M	51	168
7	F	50	168
8	M	50	24
9	F	45	156
10	F	72	228
11	F	43	144
12	F	42	108
13	F	44	168
14	F	18	84
15	F	43	84
16	F	46	168

	T. min ^o C	T. max ^o C	R.H. min %	R.H. max%
Minimum	20.7	21.9	43	49
Maximum	23.2	25.8	68	73
Average	22.05	23.8	53.5	60.6
SD	0.96	1.54	7.81	7.52

Variable	Group	Average	SD	Mean	Minimum	Maximum	N	p-Value
Age (years)	Control	55.50	20.81	55.5	18	85	16	0.083^* * Resultado do teste t-Student
	HIV+	44.94	10.33	44	18	72	16
Absolute OSDI	Control	13.79	17.13	7.15	0	70	16	0.926
	HIV+	13.18	13.16	7.67	0	41.6	16
BUT RE (seconds)	Control	7.94	2.67	10	3	10	16	0.224
	HIV+	6.56	3.27	7	2	10	16
BUT LE (seconds)	Control	7.81	2.59	9	3	10	16	0.224
	HIV+	6.31	3.26	5	2	10	16
Schirmer RE (mm)	Control	14.81	9.84	15	2	35	16	0.838
	HIV+	15.56	9.75	14.5	1	35	16
Schirmer LE (mm)	Control	15.25	8.24	13.5	6	35	16	0.809
	HIV+	15.25	9.83	11.5	3	35	16
Esthesiometry RE	Control	5.13	0.81	5.5	3.5	6	16	0.171
	HIV+	4.34	1.55	4.5	1	6	16
Esthesiometry LE	Control	5.25	0.71	5.5	3.5	6	16	0.210
	HIV+	4.41	1.54	4.75	1.5	6	16
Fluor RE	Control	0.19	0.54	0	0	2	16	0.752
	HIV+	0.06	0.25	0	0	1	16
Fluor LE	Control	0.19	0.54	0	0	2	16	0.780
	HIV+	0.25	0.58	0	0	2	16
Rose RE	Control	0.13	0.34	0	0	1	16	>0.999
	HIV+	0.13	0.34	0	0	1	16
Rose LE	Control	0.19	0.40	0	0	1	16	0.780
	HIV+	0.25	0.45	0	0	1	16

	Group
Variavel	Control		HIV+		Total		p-Value
	n	%	n	%	N	%
OSDI classification							0.809
Normal	11	68.8	12	75,0	23	71.9
Light	2	12.5	1	6,3	3	9.4
Moderate	3	18.8	3	18.8	6	18.8
Crystal RE							0.019
I	6	37.5	2	12.5	8	25.0
II	6	37.5	3	18.8	9	28.1
III	3	18.8	7	43.8	10	31.3
IV	1	6.3	4	25.0	5	15.6
Crystal LE							<0.001
I	10	62.5	2	12,5	12	37.5
II	4	25,0	1	6.3	5	15.6
III	2	12.5	5	31.3	7	21.9
IV	0	0.0	8	50.0	8	25.0
Total	16	100	16	100	32	100

Sociedade Brasileira de Oftalmologia Rua São Salvador, 107 , 22231-170 Rio de Janeiro - RJ - Brasil, Tel.: (55 21) 3235-9220, Fax: (55 21) 2205-2240 - Rio de Janeiro - RJ - Brazil
E-mail: rbo@sboportal.org.br

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[1] Corresponding author: Carolina Ramos Mosena R Borges Lagoa, 1755 – Oftalmologia, 3o andar - Vila Clementino CEP 704038-034. São Paulo – SP – Brasil Phone: (11) 5549-2937 - (11) 5088-8167 – Fax: (11) 5549-2937 E-mail: carolmosena@hotmail.com

Patient	Gender	Age	Δt Infection
1	F	46	132
2	M	41	7
3	F	44	96
4	M	43	96
5	M	41	120
6	M	51	168
7	F	50	168
8	M	50	24
9	F	45	156
10	F	72	228
11	F	43	144
12	F	42	108
13	F	44	168
14	F	18	84
15	F	43	84
16	F	46	168

Patient	Gender	Age	Δt Infection
1	F	46	132
2	M	41	7
3	F	44	96
4	M	43	96
5	M	41	120
6	M	51	168
7	F	50	168
8	M	50	24
9	F	45	156
10	F	72	228
11	F	43	144
12	F	42	108
13	F	44	168
14	F	18	84
15	F	43	84
16	F	46	168

Patient	Gender	Age	Δt Infection
1	F	46	132
2	M	41	7
3	F	44	96
4	M	43	96
5	M	41	120
6	M	51	168
7	F	50	168
8	M	50	24
9	F	45	156
10	F	72	228
11	F	43	144
12	F	42	108
13	F	44	168
14	F	18	84
15	F	43	84
16	F	46	168