Characteristics of corneal donations in state of
                    Piauí

Santos, Namir Clementino; Bezerra, Virgínia Lúcia; Melo, Eduardo Carvalho de

doi:10.5935/0034-7280.20140074

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Revista Brasileira de Oftalmologia

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• Rev. bras. oftalmol. 73 (6) • Nov-Dec 2014 • https://doi.org/10.5935/0034-7280.20140074 copy

Characteristics of corneal donations in state of Piauí

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

To describe the profile of corneal donations obtained by Ocular Tissue Bank, Hospital Getúlio Vargas (BTOC-HGV), assess the quality of the captured tissue and list the indications for corneal transplant.

Methods:

Retrospective study of registered donors in BTOC-HGV in the period 2008-2011. Collected data were: age, gender and cause of death of the donor, enucleation time, preservation time, quality of the donated cornea, causes of discards and indications for penetrating keratoplasty in BTOC.

Results:

Were analyzed 311 records of donor cornea BTOC-HGV. The number of donations increased from 9 in 2008 to 80 in 2009, 109 in 2010 and 113 in 2011. Most donors were male. The average age of the donors was 43.00 ± 16.01 years. The majority of transplanted corneas (78.6%) was optics. Were discarded 7.16% of corneal optics, mostly by new tectonic classification and detection of positive serology. The time of enucleation was 3.77 ± 2.18 hours and preservation was 6.86 ± 6.10 hours. The most frequent causes of death were external causes, followed by diseases of the circulatory, respiratory, digestive and genitourinary systems. The main indication for transplantation was bullous keratopathy, followed by keratoconus and corneal perforation.

Conclusion:

This study demonstrated the existence of factors associated with quality of corneas by BTOC as age, time between enucleation and preservation and cause of death. The main indication for transplantation was bullous keratopathy.

Corneal transplantation, donor tissue; tissue preservation; Eyes bank; Bullous keratopathy


1	2	3	4	Epithelial exposure	1	2	3	4
1	2	3	4	Epithelial defect	1	2	3	4
1	2	3	4	Subepithelial opacity	1	2	3	4
1	2	3	4	Stromal oedema	1	2	3	4
1	2	3	4	Stromal folds	1	2	3	4
1	2	3	4	Stromal infiltrate	1	2	3	4
1	2	3	4	Descemet’s membrane folds	1	2	3	4
1	2	3	4	Loss of endothelial cells	1	2	3	4
1	2	3	4	Cornea guttata	1	2	3	4
1	2	3	4	Senile arc	1	2	3	4
1	2	3	4	Pterygium	1	2	3	4
1	2	3	4	Scars	1	2	3	4
1	2	3	4	Specular reflection	1	2	3	4

Corneal quality	Time between donation and enucleation (t=0.028)	Time between enucleation and preservation (t=1.66. p=0.05)
Optical	3.82 ± 2.22	6.49 ± 5.69
Tectonic	3.49 ± 1.14	10.18 ± 7.35
Overall mean	3.77 ± 2.18	6.86 ± 6.10

Cause of death	N
External causes of morbidity and mortality	141
Diseases of the circulatory system	103
Diseases of the respiratory system	18
Diseases of the digestive system	14
Diseases of the genitourinary system	14
Neoplasms	7
Endocrine, nutritional and metabolic diseases	7
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	3
Diseases of the blood and blood-forming organs and certain immune disorders	1
Pregnancy, childbirth and the puerperium	1
Injury, poisoning and certain other consequences of external causes	1
Not identified	1

	Corneal quality
	Optical		Tectonic		Total
	N	%	N	%	N	%
External causes of morbidity and mortality	184	52,72	27	29,03	211	47,74
Diseases of the circulatory system	104	29,80	36	38,71	140	31,67
Diseases of the respiratory system	16	4,58	8	8,60	24	5,43
Diseases of the digestive system	9	2,58	10	10,75	19	4,30
Diseases of the genitourinary system	14	4,01	6	6,45	20	4,52
Neoplasms	7	2,01	1	1,08	8	1,81
Endocrine, nutritional and metabolic diseases	9	2,58			10	2,04
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	2	0,57	4	4,30	6	1,36
Diseases of the blood and blood-forming organs and certain immune disorders			1	1,08	1	0,23
Pregnancy, childbirth and the puerperium	2	0,57			2	0,45
Not identified	2	0,57			2	0,45
Total	349	100,00	93	100,00	442	100,00

Age group (X²=4.66; p=0.05)
Cause of death	Under 18		19-25		26-32		33-39		40-49		50-60		Over 60		Total
	N	%	N	%	N	%	N	%	N	%	N	%	N	%	N	%
Neoplasms	1	8.33			1	2.50					3	4.05	2	3.77	7	2.25
Diseases of the blood and blood-forming organs and certain immune disorders													1	1.89	1	0.32
Endocrine. nutritional and metabolic diseases					1	2.50			2	3.85	2	2.70	2	3.77	7	2.25
Diseases of the circulatory system	3	25.00	5 10.00		3	7.50	7	23.33	21	40.38	37	50.00	27	50.94	103	33.12
Diseases of the respiratory system	1	8.33			1	2.50			1	1.92	6	8.11	9	16.98	18	5.79
Diseases of the digestive system					3	7.50			3	5.77	4	5.41	4	7.55	14	4.50
Diseases of the genitourinary system			1 2.00				1	3.33	2	3.85	8	10.81	2	3.77	14	4.50
Pregnancy. childbirth and the puerperium							1	3.33							1	0.32
Symptoms. signs and abnormal clinical and laboratory findings. not elsewhere classified					1	2.50					1	1.35	1	1.89	3	0.96
Injury. poisoning and certain other consequences of external causes											1	1.35			1	0.32
External causes of morbidity and mortality	7	58.33	44 88.00		30	75.00	21	70.00	22	42.31	12	16.22	5	9.43	141	45.34
Not identified									1	1.92					1	0.32
Total	12	100.00	50	100.00	40	100.00	30	100.00	52	100.00	74	100.00	53	100.00	311	100.00

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[1] Corresponding author: Namir Clementino Santos, Rua Professor Clemente Fortes, 2390, São Cristóvão, Teresina/PI, Brazil. namirsantos@ig.com.br