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Unusual and aggressive presentation of intraorbital melanoma

ABSTRACT

The purpose of this study is to report a intraorbital melanoma case with atypical and aggressive presentation, forming a large painful mass with erythematosus and inflammatory aspect protruding from the left orbit with eyeball damaged at its peak. Piece analysis identified malignant melanoma compound of epithelioid, spindle and anaplastic cells.

Keywords:
Melanoma; Eye neoplasms; Uveal neoplasms; Orbital diseases; Orbital neoplasms; Case reports

RESUMO

O objetivo dos autores é relatar um caso de melanoma intraorbitário de apresentação atípica e agressiva, formando grande massa dolorosa de aspecto eritematoso e inflamatório projetando-se da órbita esquerda com o globo ocular danificado em seu ápice. A análise da peça identificou melanoma maligno com componentes celulares epitelióide, fusocelular e anaplásico.

Descritores:
Melanoma; Neoplasias oculares; Neoplasias uveais; Doenças orbitárias; Neoplasias orbitárias; Relatos de casos

INTRODUCTION

Uveal melanoma is the most common primary intraocular tumor in adults.(11 Torossian NM, Wallace RT, Hwu WJ, Bedikian AY. Metastasis of ciliary body melanoma to the contralateral eye: A case report and review of uveal melanoma literature. Case Rep Oncol Med. 2015;2015:427163) Depending on the location and size, it can be asymptomatic or cause a wide variety of symptoms, such as worsening of visual acuity, floaters, loss of part of the visual field, or eye pain. Histologi-cally, melanoma is presented in different cell types, with epithelioid and anaplastic being the worst prognosis.(22 Costache M, Patrascu OM, Adrian D, Costache D, Sajin M, Ungureanu E, et al. Ciliary body melanoma - A particularly rare type of ocular tumor. Case report and general considerations. Maedica (Buchar). 2013;8(4):360-4.) There were advances in diagnostic methods, but mortality as a result of the tumor has not changed much in recent years.(33 Singh AD, Turell ME, Topham AK. Uveal melanoma: trends in incidence, treatment, and survival. Ophthalmology. 2011;118(9):1881-5.)

Our purpose was to make a brief review of current issues related to the subject and report an intraorbital melanoma case of atypical presentation with rapid growth, poor prognosis and recurrence after surgery.

CASE REPORT

Patient JVS, 57 years old, male, came for urgent care at the emergency of the ophthal-mology service at Hospital Governador Celso Ramos - Florianópolis on March 2015 complaining of severe pain and mass in the left orbit. During the first appointment, he men-tioned trauma in left eye with foreign body 6 months before, and mass growth followed by pain since then. The examination showed erythematous, fixed mass, protruding approxi-mately 3 cm from the left orbit with exposed cornea and damage, upper eyelid free, edem-atous and unable occlude the region exposed. (Figure 1) There was no pain on palpation, any ocular motility, no light perception and lack of secretion. Former morbid story without any particularity. He denied use of eyedrops or previous surgery in the eye. He reported having normal vision until 6 months prior to the appointment. The right eye was normal to the exam, with visual acuity 20/20 and without any other particularity.

Figure 1
Patient with large, fixed erythematous mass, projecting from the left orbital cavity

CT scan of the skull was performed showing large ovoid intraorbital mass with erosion of cortical bone and invasion of extraocular muscles.(Figure 2) The material collected for bi-opsy showed inconclusive results.The immunohistochemical analysis conducted then showed positive AE1/AE3 cytokeratin in epithelial cells, negative epithelial membrane an-tigen, positive S100 protein in the stromal cells, and positive CD31 in the endothelium. Af-ter the results, the patient returned to service with increased mass and persistence of pain, nintratumoral necrose, vascular and nervous invasion with staging pT4a. (Figure 3) The patient was then referred to the oncology service.

Figure 2
Computed tomography of orbit, revealing ovoid infraorbital mass with erosion of cortical bone and invasion of extraocular muscles.

Figure3
Histopathology slide

Approximately thirty days after, he returned with large mass relapse, now more darkened, crumbly without adhesion to the upper eyelid margin. At this point, we decided not to inter-vene surgically, analgesia remained, and he was referred to the oncology service. (Figure 4)

Figure 4
Patient photograph showing the appearance of the tumor relapse in the left orbital caviy.

DISCUSSION

The uveal melanoma, an entity that may affect the iris, ciliary body and choroid due to the presence of melanocytes in their tissues, is the most common primary intraocular tumor in adults.(11 Torossian NM, Wallace RT, Hwu WJ, Bedikian AY. Metastasis of ciliary body melanoma to the contralateral eye: A case report and review of uveal melanoma literature. Case Rep Oncol Med. 2015;2015:427163) Melanomas of the ciliary body can be initially asymptomatic and

difficult to see due to its location behind the iris, and the first symptoms may be nonspecific, such as poor visual acuity, floaters, loss of visual field or ocular pain due to secondary glaucoma.(22 Costache M, Patrascu OM, Adrian D, Costache D, Sajin M, Ungureanu E, et al. Ciliary body melanoma - A particularly rare type of ocular tumor. Case report and general considerations. Maedica (Buchar). 2013;8(4):360-4.) The choroidal melanomas typically assume the dome conformation, pigmented and elevated below the retina, with color ranging from amelanotic to dark brown, and bringing more symptoms related to visual acuity.(44 American Academy of Ophthalmology. Ophthalmic Pathology and Intraocular Tumors: San Francisco: American Academy of Ophthalmology; 2014. p. 264-87.) Our case shows a patient in advanced stage of the disease with the content and orbital continent compromised.

Epidemiologically, the patient lies within the age group with the highest incidence of the disease, and a recent study shows that there may be some relation between the patient's age and the type of melanoma cell, with fusiform being the most prevalent in patients with average of 60 years, epitelioide with 65 years old, and mixed with 64 years old, but such correlation did not correspond to the case.(55 Andreoli MT, Mieler WF, Leiderman YI. Epidemiological trends in uvealmelanoma. Br J Ophthalmol. 2015 Apr 22. pii: bjophthalmol-2015-306810. doi:10.1136/bjophthalmol-2015306810.
https://doi.org/10.1136/bjophthalmol-201...
)

Despite the better accuracy in diagnosis, mortality as a result of these tumors has not changed significantly in recent years.(33 Singh AD, Turell ME, Topham AK. Uveal melanoma: trends in incidence, treatment, and survival. Ophthalmology. 2011;118(9):1881-5.) The incidence of metastasis is high, and survival in metastatic cases is on average of 12 months, with the liver being the most affected organ.(11 Torossian NM, Wallace RT, Hwu WJ, Bedikian AY. Metastasis of ciliary body melanoma to the contralateral eye: A case report and review of uveal melanoma literature. Case Rep Oncol Med. 2015;2015:427163)

Enucleation is the appropriate treatment for medium (T2), large (T3) and very large (T4) tumors, and in cases of pain. Small and medium-sized tumors, without documented growth and with less than 1 mm thick can be treated more conservatively with brachytherapy, which offers good rates to control the disease, but little is known about the survival of these patients who were treated conservatively, although a study confirms the reduction of mortality in the following years.(44 American Academy of Ophthalmology. Ophthalmic Pathology and Intraocular Tumors: San Francisco: American Academy of Ophthalmology; 2014. p. 264-87.

5 Andreoli MT, Mieler WF, Leiderman YI. Epidemiological trends in uvealmelanoma. Br J Ophthalmol. 2015 Apr 22. pii: bjophthalmol-2015-306810. doi:10.1136/bjophthalmol-2015306810.
https://doi.org/10.1136/bjophthalmol-201...
-66 Lane AM, Kim IK, Gragoudas ES. Long-term risk of melanoma-related mortality for patients with uveal melanoma treated with proton beam therapy. JAMA Ophthalmol. 2015;133(7):792-6.) There is a consensus that the conventional external radiotherapy is not effective as a single mode of treatment of melanoma, and cases where the enucleation was required even after the radiation therapy are associated to the worst prognosis.(44 American Academy of Ophthalmology. Ophthalmic Pathology and Intraocular Tumors: San Francisco: American Academy of Ophthalmology; 2014. p. 264-87.

5 Andreoli MT, Mieler WF, Leiderman YI. Epidemiological trends in uvealmelanoma. Br J Ophthalmol. 2015 Apr 22. pii: bjophthalmol-2015-306810. doi:10.1136/bjophthalmol-2015306810.
https://doi.org/10.1136/bjophthalmol-201...

6 Lane AM, Kim IK, Gragoudas ES. Long-term risk of melanoma-related mortality for patients with uveal melanoma treated with proton beam therapy. JAMA Ophthalmol. 2015;133(7):792-6.
-77 Van den Bosch T, Vaarwater J, Verdijk R, Muller K, Kiliç E, Paridaens D, et al. Risk factors associated with secondary enucleation after fractionated stereotatic radiotherapy in uveal melanoma. Acta Ophthalmol. 2015;93(6):555-60.) The exenteration, traditionally indicated for posterior uveal melanomas with extra-escleral expansion, is today little indicated due to enucleation and radiation therapy show similar survival outcomes.(44 American Academy of Ophthalmology. Ophthalmic Pathology and Intraocular Tumors: San Francisco: American Academy of Ophthalmology; 2014. p. 264-87.

5 Andreoli MT, Mieler WF, Leiderman YI. Epidemiological trends in uvealmelanoma. Br J Ophthalmol. 2015 Apr 22. pii: bjophthalmol-2015-306810. doi:10.1136/bjophthalmol-2015306810.
https://doi.org/10.1136/bjophthalmol-201...

6 Lane AM, Kim IK, Gragoudas ES. Long-term risk of melanoma-related mortality for patients with uveal melanoma treated with proton beam therapy. JAMA Ophthalmol. 2015;133(7):792-6.

7 Van den Bosch T, Vaarwater J, Verdijk R, Muller K, Kiliç E, Paridaens D, et al. Risk factors associated with secondary enucleation after fractionated stereotatic radiotherapy in uveal melanoma. Acta Ophthalmol. 2015;93(6):555-60.
-88 Cunha AM, Rodrigues NHT, Almeida GA, Picanço BC, Netto JA. Melanoma de corpo ciliar e coróide: Relato de caso. Arq Bras Oftalmol. 2010;73(2):193-6.) We chose exenteration in this case due to the pain symptoms and the large volume and invasion of the tumor mass. A study that evaluated patients who suffered enucleation showed that the recurrence can occur in 3% of cases of melanoma restricted to the intraocular compartment, and in 18% of cases in which there is evidence of extra-escleal extension.(99 Akashi PM, Kitagawa VM, Chahud F, Cruz AA. Melanoma em cavidade anoftálmica secundária a evisceração - Relato de 2 casos e revisão da literatura. Arq Bras Oftalmol. 2004;67(6):969-72.) The degree of the lesion and rapid recurrence give this case a reserved prognosis.

REFERÊNCIAS

  • 1
    Torossian NM, Wallace RT, Hwu WJ, Bedikian AY. Metastasis of ciliary body melanoma to the contralateral eye: A case report and review of uveal melanoma literature. Case Rep Oncol Med. 2015;2015:427163
  • 2
    Costache M, Patrascu OM, Adrian D, Costache D, Sajin M, Ungureanu E, et al. Ciliary body melanoma - A particularly rare type of ocular tumor. Case report and general considerations. Maedica (Buchar). 2013;8(4):360-4.
  • 3
    Singh AD, Turell ME, Topham AK. Uveal melanoma: trends in incidence, treatment, and survival. Ophthalmology. 2011;118(9):1881-5.
  • 4
    American Academy of Ophthalmology. Ophthalmic Pathology and Intraocular Tumors: San Francisco: American Academy of Ophthalmology; 2014. p. 264-87.
  • 5
    Andreoli MT, Mieler WF, Leiderman YI. Epidemiological trends in uvealmelanoma. Br J Ophthalmol. 2015 Apr 22. pii: bjophthalmol-2015-306810. doi:10.1136/bjophthalmol-2015306810.
    » https://doi.org/10.1136/bjophthalmol-2015306810
  • 6
    Lane AM, Kim IK, Gragoudas ES. Long-term risk of melanoma-related mortality for patients with uveal melanoma treated with proton beam therapy. JAMA Ophthalmol. 2015;133(7):792-6.
  • 7
    Van den Bosch T, Vaarwater J, Verdijk R, Muller K, Kiliç E, Paridaens D, et al. Risk factors associated with secondary enucleation after fractionated stereotatic radiotherapy in uveal melanoma. Acta Ophthalmol. 2015;93(6):555-60.
  • 8
    Cunha AM, Rodrigues NHT, Almeida GA, Picanço BC, Netto JA. Melanoma de corpo ciliar e coróide: Relato de caso. Arq Bras Oftalmol. 2010;73(2):193-6.
  • 9
    Akashi PM, Kitagawa VM, Chahud F, Cruz AA. Melanoma em cavidade anoftálmica secundária a evisceração - Relato de 2 casos e revisão da literatura. Arq Bras Oftalmol. 2004;67(6):969-72.

Publication Dates

  • Publication in this collection
    Nov-Dec 2016

History

  • Received
    03 Aug 2015
  • Accepted
    08 Nov 2015
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