Ascione et al.3535 Ascione T, Pagliano P, Balato G, Mariconda M, Rotondo R, Esposito S. Oral therapy, microbiological findings, and comorbidity influence the outcome of prosthetic joint infections undergoing 2-stage exchange. J Arthroplasty 2017;32(07):2239–2243
|
2017 |
122 PJI |
Single center - Italy |
S. aureus - 36%
CoNS - 34%
|
- Presence of comorbidities increased the risk of PJI |
Bänke et al.1414 Banke IJ, Stade N, Prodinger PM, Tübel J, Hapfelmeier A, von Esenhart-RotheR, et al. Antimicrobial peptidesin human synovial membrane as (low-grade) periprosthetic joint infection biomarkers. Eur J Med Res 2020;25(01):33
|
2020 |
25 PJI |
Single center- Germany |
MMSA - 100% (study bias) |
- Antimicrobial peptides as PJI biomarkers |
Barbero et al.3232 BarberoJM, Romanyk J, Vallés A, Plasencia MA, Montero E, López J. [Decolonization for Staphylococcus aureus carriers in arthroplasty surgery after hip fracture]. Rev Esp Quimioter 2017;30 (04):264–268
|
2017 |
307 patients |
Single center - Spain |
S. aureus - 28.3% |
- Decolonization with intranasal mupirocin and Chlorhexidine baths effective for PJI reduction. |
Bauer et al.1515 Bauer T, Marmor S, Ghout I, Salomon E, El Sayed F, Heym B, et al. Measurement of serum anti-staphylococcal antibodies increases positive predictive value of preoperative aspiration for hip prosthetic joint infection. Clin Orthop Relat Res 2020;478(12): 2786–2797
|
2020 |
340 patients |
Single center - France |
S. aureus - 21 % |
- Gold standard intraoperative tissue culture for infectious definition
- Measurement of serum anti-staphylococcal antibodies increased positive predictive value of synovial fluid culture for diagnosis of PJI
|
Çimen et al.3434 Çimen O, Azboy N, Çatal B, Azboy İ Assessment of periprosthetic joint infection prevention methods amongst Turkish orthopedic surgeons in total joint replacement: A survey. Jt Dis Relat Surg 2020;31(02):230–237
|
2020 |
354 surgeons |
Single center - Turkey |
Variable not addressed |
- Time of antibiotic prophylaxis longer than proposed by guidelines
- Blood glucose measurement performed by 94% of the sample -Decolonization for MRSA performed by 33.3%
|
Guo et al.2020 Guo H, Xu C, Chen J. Risk factors for periprosthetic joint infection after primary artificial hip and knee joint replacements. J Infect Dev Ctries 2020;14(06):565–571
|
2020 |
96 PJI |
Single center - China |
S. epidermidis - 38.10% |
- Risk factors for PJI: obesity, longer surgical time, and immunosuppression. |
Hariharan et al.1313 Hariharan TD, Chandy VJ, George J, Mathew AJ, Premnath J, Pragasam AK, et al. Microbiological profile and outcomes of two-stage revision hip arthroplasty. Indian J Med Microbiol 2019;37(01):67–71
|
2019 |
22 patients |
Single center - India |
S. aureus- 18% |
- ESR > 30mm/h had a sensitivity of 75% and specificity of 88% in predicting PJI.
- CRP > 1 0mg/L had a sensitivity of 75% and a specificity of 69%.
|
Hartman et al.1212 HartmanCW,Daubach EC, Richard BT, LydenER, Haider H, Kildow BJ, et al. Predictors of reinfection in prosthetic joint infections following two-stage reimplantation. J Arthroplasty 2022;37(7S): S674–S677
|
2022 |
158 PJI |
Single center - EUA |
MSSA-19.6% |
- CRP was a marker of reinfection in patients with PJI |
Morgenstern et al.1010 Morgenstern C, Cabric S, Perka C, Trampuz A, Renz N. Synovial fluid multiplex PCR is superior to culture for detection of low-virulent pathogens causing periprosthetic joint infection. Diagn Microbiol Infect Dis 2018;90(02):115–119
|
2018 |
142 patients |
Single center- Germany |
CoNS-14.33% S. aureus- 19% |
- PJI in 54% sample
- Aseptic failure 46%
|
Papalini et al.88 Papalini C, Pucci G, Cenci G, Mencacci A, Francisci D, Caraffa A, et al. Prosthetic joint infection diagnosis applying the three-level European Bone and Joint Infection Society (EBJIS) approach. Eur J Clin Microbiol Infect Dis 2022;41(05):771–778
|
2022 |
63 PJI |
Single center - Italy |
S. aureus - 20.3% CONS-20.3% Streptococcus spp. - 7.5% |
-Approves EBJIS criteria
- Suggests combination of techniques for diagnosing PJI.
|
Pietrazak et al.2121 Pietrzak JRT, Maharaj Z, Mokete L. Prevalence of Staphylococcus aureus colonization in patients for total joint arthroplasty in South Africa. J Orthop Surg Res 2020;15(01):123
|
2020 |
119 patients |
Single center - South Africa |
MSSA-31.9% MRSA - 0% |
- Combined intranasal mupirocin ointment and Chlorhexidine body wash for decolonization. |
Rohrer et al.2626 Rohrer F, Wendt M, Noetzli H, Risch L, Bodmer T, Cottagnoud P, et al. Preoperative decolonization and periprosthetic joint infections-A randomized controlled trial with 2-year follow-up. J Orthop Res 2021;39(02):333–338
|
2021 |
1318 patients |
Single center - Switzerland |
S. aureus - 34% |
- PJI index of 0.3% |
Rosteius et al.1919 Rosteius T, Jansen O, Fehmer T, Baecker H, Citak M, Schildhauer TA, et al. Evaluating the microbial pattern of periprosthetic joint infections of the hip and knee. J Med Microbiol 2018;67(11): 1608–1613
|
2018 |
477 patients |
Single center- Germany |
MSSA-28.2% MRSE-13.2% MRSA-6.6% CoNS-16.4% |
- Risk factors for PJI: multicomorbidities, advanced age and obesity. |
Scholten et al.2727 Scholten R, Hannink G, Willemsen K, Mascini EM, Somford MP, Schreus BW, et al. Preoperative Staphylococcus aureus screening and eradication. Bone Joint J 2020;102-B(10):1341–1348
|
2020 |
10486 patients |
Single center - Netherland |
S. aureus - 26.7% |
- Nasal screening and eradication protocol did not reduce global PJI but reduced early S. aureus-induced PJI. |
Schweitzer et al.1717 Schweitzer D, Klaber I, García P, López F, Lira MJ, Botello E. Methicillin-resistant Staphylococcus aureus colonization in patients undergoing primary total hip arthroplasty. J Med Microbiol 2020;69(04):600–604
|
2021 |
146 patients |
Single center - Chile |
MRSA-5% |
- Larger MRSA colonization in the inguinal region
- Recent use of antibiotics as an important risk factor
|
Stambough et al.3333 Stambough JB, Nam D, Warren DK, Keeney JA, Clohisy JC, Barrack RL, et al. Decreased Hospital Costs and Surgical Site Infection Incidence With a Universal Decolonization Protocol in Primary Total Joint Arthroplasty. J Arthroplasty 2017;32 (03):728–734.e1
|
2017 |
4.186 patients |
Single center - USA |
MRSA-0.09% |
- Universal decolonization reduced PJI and surgical site infections |
Tani et al.99 Tani S, Lepetsos P, Stylianakis A, Vlamis J, Birbas KKaklamanos I. Superiority of the sonication method against conventional periprosthetic tissue cultures for diagnosis of prosthetic joint infections. Eur J Orthop Surg Traumatol 2018;28(01): 51–57
|
2018 |
114 patients |
Single center- Greece |
Variable not addressed |
- Culture sensitivity of the sonication fluid of 77.04%,
- Sensitivity of conventional tissue cultures of 55.73%
|
Tonotsuka et al.2525 Tonotsuka H, Sugiyama H, Amagami A, Yonemoto K, Sato R, Saito M. What is the most cost-effective strategy for nasal screening and Staphylococcus aureusdecolonization inpatients undergoing total hip arthroplasty? BMC Musculoskelet Disord 2021;22; (01):129
|
2021 |
1654 patients |
Single center - Japan |
S. aureus - 26.9%
MRSA- 1.8%
|
- Combined intranasal mupirocin ointment for decontamination
- Female sex as a risk factor for greater colonization by S. aureus
|
Tsai et al.1818 Tsai Y, Chang CH, Lin YC, Lee SH, Hsieh PH, Chang Y. Different microbiological profiles between hip and knee prosthetic joint infections. J Orthop Surg (Hong Kong) 2019;27(02): 2309499019847768
|
2019 |
159 PJI |
Single center - Taiwan |
S. aureus - 27%
MRSA - 21%
CoNS - 14%
|
- Empirical antibiotic therapy with wide coverage until PJI culture. |
Villa et al.1616 Villa JM, Pannu TS, Theeb I, Buttaro MA, Oñativia JI, Carbo L, et al. International Organism Profile of Periprosthetic Total Hip and Knee Infections. J Arthroplasty 2021;36(01):274–278
|
2021 |
361 PJI |
Multicenter- North
America / South
America and Europe
|
S. aureus - 24.8%
S. epidermidis -21.7%
Polymicrobial - 10.5%
|
- 62.3% resistant to at least 1 antibiotic. |