Determine the role of interleukine - 1beta (IL-1beta) as intercellular mediator in generation, amplification and maintenance of inflammatory and immune responses in periodontal disease. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: Assessment of concentration of 1L-1beta in group I (20 samples of healthy people) and in group II (20 samples of patients with periodontal disease), employing Easia Kit (Medgenix 1L-1beta), with results statistically analyzed through Student t Test. RESULTS: In control group, media and standard deviation of 1L-1beta concentration were 71,28 ± 280,05 pg/ml and in periodontal disease 3618,49 ± 2864,75 pg/ml. CONCLUSION: The increase of Interleucine 1beta in periodontal disease distinguish from healthy oral mucosa.
periodontal disease; interleukine 1beta
