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Lymphoma's manifestations in Sjögren's syndrome: is there a relation?

Sjögren's Syndrome (SS) is considered a multisystemic chronic disorder, which is characterized by a lymphocytic infiltration of exocrine glands and autoantibodies production. AIM: Several studies have demonstrated increased incidence of Lymphoma in SS patients. Our study tries to determine this relation. STUDY DESIGN: Transversal cohort. MATERIAL AND METHOD: Patients with Sicca's Syndrome from the Stomathology service, Santa Casa de Misericórdia Hospital, in Sao Paulo, ENT Department, from July 1999 to April 2002. RESULTS: Out of 39 patients, 24 were diagnose as SS. Ages ranged from 19 to 83 years old, with predominance of women (69.7%). Time between the first symptoms and SS diagnosis were variable, ranging within 3.77 years. None of the analyzed patients developed lymphoma. CONCLUSION: Both SS early diagnosis and the increased risk of lymphoma's development in those patients are important, reason why long-term follow-up is essential. We observed that our findings were different from those in the literature. We did not detect any cases of lymphoma in our patients.

Sjögren's syndrome; lymphoma; Sicca's syndrome


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