Albendazole is effective in controlling monogeneans in <i>Colossoma macropomum</i> (Serrasalmidae): therapeutic baths and their physiological and histopathological effects

Baia, Raimundo Rosemiro de Jesus; Alves, Carliane Maria Guimarães; Oliveira, Marcos Sidney Brito de; Salomão, Clara Brito; Carvalho, Abthyllane Amaral de; Videira, Marcela Nunes; Yoshioka, Eliane Tie Oba; Tavares-Dias, Marcos

doi:10.1590/S1984-29612024044

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Revista Brasileira de Parasitologia Veterinária

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Original Article • Rev. Bras. Parasitol. Vet. 33 (3) • 2024 • https://doi.org/10.1590/S1984-29612024044 copy

Albendazole is effective in controlling monogeneans in Colossoma macropomum (Serrasalmidae): therapeutic baths and their physiological and histopathological effects

Albendazol tem eficácia em controlar monogenéticos em Colossoma macropomum (Serrasalmidae): banhos terapêuticos e seus efeitos fisiológicos e histopatológicos

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

In aquaculture worldwide, most of the chemotherapeutic agents used for disease control and treatment are unregulated chemical products derived from agriculture. In this study, we investigated the efficacy of therapeutic baths with albendazole against the monogeneans Anacanthorus spathulatus, Notozothecium janauachensis and Mymarothecium boegeri, which infest the gills of Colossoma macropomum, and the hematological and histopathological effects of this anthelmintic agent on these fish. Albendazole at a concentration of 500 mg/L was used in three baths of 24 hours each, with intervals of 24 hours between these baths. Three replications of this treatment were used, and the control group consisted of water from the cultivation tank. Afterwards, hematological, histopathological and parasitological analyses were conducted. We found that the therapeutic baths with albendazole at 500 mg/L presented high efficacy (94.9%) against monogeneans de C. macropomum and caused few physiological or histopathological alterations. Therefore, baths with albendazole at 500 mg/L, as used in this strategy, can be recommended for controlling and treating infections by monogeneans in C. macropomum.

Keywords:
Anthelmintic; parasites; tambaqui; treatment

Treatments	P (%)	MA	E (%)
Water (control)	100	11.07 ± 11.55^a	-
Albendazole at 500 mg/L	33.3	0.57 ± 1.01^b	94.9

Parameters	Water (control)	Albendazole at 500 mg/L
Glucose (g/dL)	64.4 ± 19.7^a	107.3 ± 23.6^b
Total protein (mg/dL)	2.8 ± 0.4^a	3.2 ± 0.4^b
Erythrocytes (x 10⁶ /μL)	1.43 ± 0.19^a	1.48 ± 0.29^a
Hemoglobin (g/dL	5.5 ± 0.5^a	5.9 ± 0.8^a
Hematocrit (%)	24.3 ± 2.0^a	25.8 ± 3.1^a
MCV (fL)	171.9 ± 20.1^a	178.8 ± 29.9^a
MCHC (g/dL)	22.9 ± 1.4^a	23.0 ± 2.8^a
Thrombocytes (μL)	88,023 ± 16,002^a	77,691 ± 15,505^a
Leukocytes (μL)	144,279 ± 21,156^a	151,045 ± 30,756^a
Lymphocytes (μL)	63,972 ± 10,103^a	68,462 ± 15,341^a
Monocytes (μL)	52,210 ± 6.290^a	53,303 ± 9.393^a
Neutrophils (μL)	16,109 ± 5.255^a	19,260 ± 6.381^a
Eosinophils (μL)	4.676 ± 1.567^a	3.351 ± 1.810^b
PAS-GL (μL)	6.451 ± 3.151^a	6.032 ± 2.942^a

Treatments	N	MAV	HAI	Severity of the lesions according to HAI
Water	9	9.8 ± 1.9^a	18.2 ± 55^a	Mild to moderate organ damage
Albendazole at 500 mg/L	9	111 ± 2.9^a	19.3 ± 4.8^a	Mild to moderate organ damage

Colégio Brasileiro de Parasitologia Veterinária FCAV/UNESP - Departamento de Patologia Veterinária, Via de acesso Prof. Paulo Donato Castellane s/n, Zona Rural, , 14884-900 Jaboticabal - SP, Brasil, Fone: (16) 3209-7100 RAMAL 7934 - Jaboticabal - SP - Brazil
E-mail: cbpv_rbpv.fcav@unesp.br

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[1] *Corresponding author: Raimundo Rosemiro de Jesus Baia. E-mail: rdobaia@gmail.com