Association of <i>PDCD1</i> polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility

Canto, Luisa Matos do; Farias, Ticiana Della Justina; Medeiros, Mayara Delagnelo; Coêlho, Cíntia Callegari; Sereia, Aline Fernanda Rodrigues; Back, Lia Kubelka Fernandes de Carlos; Mello, Filipe Martins de; Zimmermann, Adriana Fontes; Pereira, Ivânio Alves; Souza, Ilíada Rainha de

doi:10.1016/j.rbre.2015.07.008

Luisa Matos do Canto

Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil

1 Both of these authors equally contribued to this work.

Ticiana Della Justina Farias

Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil

1 Both of these authors equally contribued to this work.

Mayara Delagnelo Medeiros

Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil

Cíntia Callegari Coêlho

Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil

Aline Fernanda Rodrigues Sereia

Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil

Lia Kubelka Fernandes de Carlos Back

Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil

Filipe Martins de Mello

Universidade do Estado de São Paulo, Faculdade de Medicina, Serviço de Reumatologia, São Paulo, SP, Brazil

Adriana Fontes Zimmermann

Universidade Federal de Santa Catarina, Hospital Universitário, Divisão de Reumatologia, Florianópolis, SC, Brazil

Ivânio Alves Pereira

Universidade Federal de Santa Catarina, Hospital Universitário, Divisão de Reumatologia, Florianópolis, SC, Brazil

Ilíada Rainha de Souza ^**Corresponding author. E-mail: iliadarainha@gmail.com (I.R. Souza).

Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil

*Corresponding author. E-mail: iliadarainha@gmail.com (I.R. Souza).

Conflicts of interest

The authors declare no conflicts of interest.

1
Both of these authors equally contribued to this work.

	SLE patients n	RA patients n	Controls n
Female (%)	92 (96.84)	75 (86.21)	123 (96.09)
Mean age (SD)	37,35 (±12,16)	54.42 (±13.33)	47,38 (±15.04)

	SLE	p value	RA	p value	Controls n = 128
	n = 95		n = 87
Allele G	0.905	(Ref.)	0.885	(Ref.)	0.922
Allele A	0.095	0.661	0.115	0.364	0.078
GG	0.842	(Ref.)	0.816	(Ref.)	0.859
GA	0.126	0.940	0.138	0.715	0.125
AA	0.032	0.755	0.046	0.206	0.016
HWE (p value)	χ²₍₁₎ = 6.60 (0.010)		χ²₍₁₎ = 9.02 (<0.001)		χ²₍₁₎ = 2.24 (0.130)

	Affected SLE patients n (%)	Associated p value
		Allele (A)	AA	AA + AG
Arthritis	47 (49.5)	0.963	0.553	0.752
Photosensitivity	38 (40)	0.312	0.361	0.294
Raynaud's phenomenon	14 (15.8)	0.570	0.827	0.777
Renal impairment	29 (30.5)	0.786	0.440	0.388
	Affected RA patients n (%)	Associated p value
		Allele (A)	AA	AA + AG
RF	50 (66.67)	0.122	0.291	0.302
CRP	36 (46.15)	0.910	0.874	0.965

Population	Studied disease	PD1.3A frequencies %		OR (95% CI)	Reference
		Controls	Patients
Swedish	SLE	8.0	11.0	1.44 (0.93–2.23)	Prokunina et al., 2002
Mexican	SLE	2.0	7.0	3.23 (1.46–7.16)^b b p < 0.05 statistically significant.	Prokunina et al., 2002
Danish	T1D	6.8	12.2	1.92 (1.1–3.3)^b b p < 0.05 statistically significant.	Nielsen et al., 2003
Spanish	SLE	12.9	9.4	0.70 (0.54–0.90)^b b p < 0.05 statistically significant.	Ferreiros-Vidal et al., 2004
Danish	SLE	6.8	11.6	1.80 (0.96–3.4)	Nielsen et al., 2004
European (women)	SLE	7.0	11.0	1.60 (1.17–2.18)^b b p < 0.05 statistically significant.	Prokunina et al., 2004a
Swedish	RA	7.3	8.5	1.18 (0.99–1.4)	Prokunina et al., 2004b
African American (women)	SLE	10.0	5.0	2.19 (0.54–8.85)	Sanghera et al., 2004
European American (women)	SLE	11.0	13.0	1.23 (0.87–1.73)	Sanghera et al., 2004
North Swedish	SLE	5.6	7.3	1.35 (0.90–2.02)	Johansson et al., 2005
Hong Kong Chinese	RA	0	0	NA	Kong et al., 2005
Finnish	SLE	6.0	3.0	0.50 (0.20–1.26)	Sigurdsson et al., 2005
Swedish	SLE	9.0	9.0	1.00 (0.68–1.45)	Sigurdsson et al., 2005
Mato Grosso do Sul – Brazilian	Pemphigus Foliaceus	9.6	5.8	0.58 (0.33–1.03)	Braun-Prado and Petzel-Erler 2007
CEU^a a Collections of samples from Germany, the Czech R. and Hungary were grouped as CEU; collections from Milan, Rome and Naples were grouped as Italy; collections from Greece were considered by their own (as presented by Ferreiros-Vidal et al.51).	SLE	8.1	17.1	2.35 (1.1–4.9)^b b p < 0.05 statistically significant.	Ferreiros-Vidal et al., 2007
Italian^a a Collections of samples from Germany, the Czech R. and Hungary were grouped as CEU; collections from Milan, Rome and Naples were grouped as Italy; collections from Greece were considered by their own (as presented by Ferreiros-Vidal et al.51).	SLE	10.7	18.7	1.92 (0.9–3.9)	Ferreiros-Vidal et al., 2007
Greek	SLE	10.6	12.7	1.22 (0.8–1.8)	Ferreiros-Vidal et al., 2007
Japanese	RA	0	0	NA	Iwamoto et al., 2007
British	Graves’ disease	88.4	89.7	1.13 (0.85–1.50)	Sutherland et al., 2007
American	SLE	4.7	7.2	1.59 (0.78–3.23)	Thorburn et al., 2007
Mexican	Childhood-onset SLE	2.0	5.2	2.73 (1.35–5.56)	Velázquez-Cruz et al., 2007
American	Primary biliary cirrhosis	11.7	12.5	1.08 (0.74–1.57)	Juran et al., 2008
Swedish	Autoimmune HMG	8.5	10.8	1.32 (0.74–2.35)	Sakthivel et al., 2008
French	CMV infection after kidney transplantation	12.9	12.8	1.38 (0.90–2.11)	Hoffmann et al., 2009
Han Chinese	Vogt–Koyanagi–Harada syndrome	0	0	NA	Meng et al., 2009
Caucasian Polish	T1D	12.9	13.5	1.05 (0.71–1.55)	Fichna et al., 2010
Iranian	Ankylosing spondylitis	11.2	9.3	0.81 (0.48–1.34)	Soleimanifar et al., 2010
Mexican	Hypersensitivity pneumonitis	3.8	6.1	1.65 (0.59–4.75)	Zúñiga et al., 2010
Caucasian Polish	Chronic urticaria	10.0	10.0	0.97 (0.51–1.86)	Brzoza et al., 2012
Brazilian	Silica-exposed workers	13.3	4.3	0.29 (0.10–0.88)^b b p < 0.05 statistically significant.	Rocha et al., 2012
African American	SLE	2.0	2.6	1.31 (0.94–1.81)	Sanchez et al., 2012
Brazilian	Chagas disease	10.0	9.0	0.90 (0.61–1.33)	Dias et al., 2013
German	Liver transplant recipients	12.5	10.0	0.78 (0.46–1.33)	Thude et al., 2013
Iranian	Colorectal cancer	40.5	60.6	2.27 (1.50–3.44)^b b p < 0.05 statistically significant.	Yousefi et al., 2013
Han Chinese	RA	0	0	NA	Liu et al., 2014

[1] *Corresponding author. E-mail: iliadarainha@gmail.com (I.R. Souza).

Brasil

Brasil

Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility

ABSTRACT

Objective:

Methods:

Results:

Conclusion: