The contribution of HLA molecules to Dupuytren's
               contracture in a Southeast Brazilian population

Usó, Sônia Maria Ruiz Silva; Sanson, Ana Claudia Santos; Covolo-Santana, Fabiana de Souza; Marcos, Elaine Valim Camarinha; Marques, Tatiani; Cury Filho, Milton; Ura, Somei

doi:10.1016/j.rbr.2014.01.004

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Original articles • Rev. Bras. Reumatol. 54 (1) • Jan-Feb 2014 • https://doi.org/10.1016/j.rbr.2014.01.004 linkcopy

The contribution of HLA molecules to Dupuytren's contracture in a Southeast Brazilian population

Authorship SCIMAGO INSTITUTIONS RANKINGS

Purpose: The aim of the present study was to investigate the HLA phenotype in Dupuytren's contracture (DC) patients in order to verify the correlation of these alleles with risk factors for development of DC in the Brazilian population.

Methods: This was a case-controlled study of 25 DC patients and 443 healthy individuals with no history of HLA-associated diseases. HLA class I and class II typing was performed using the polymerase chain reaction sequence-specific primer method.

Results: The HLAB*18 phenotype was observed in 32% of the patients and 10.5% of controls. However, P values did not remain significant after correction.

Discussion: Although we observed an increased tendency of DC patients to possess the HLA-B*18 allele, the results were not statistically significant after correction. This allele was higher in patients of Italian and/or Spanish ethnicity, localities with frequencies higher than 18.0% and 14.0% respectively. Further investigation with a larger cohort of DC patients is required to confirm the potential role of HLA in this disease.

Dupuytren's contracture; HLA; Major histocompatibility complex; Disease association; Immunogenetics

Patient	Gender	Age	Ocupation	Ancestry
1	M	40	cutlery	Spanish
2	M	50	farmer	Portuguese
3	F^a	49	housewife	German/ Portuguese
4	M	46	farmer	Italian
5	M	50	professor	Portuguese
6	M^a	43	driver	German/Italian
7	M	50	bricklayer	Spanish
8	M	55	economist	Italian/Spanish
9	M	55	machineoperator	Italian/Brazilian
10	F^a	63	housewife	Brazilian
11	F	46	sales representative	Italian/Portuguese
12	M	63	farmer	Italian/Portuguese
13	F	74	farmer	Italian/Brazilian
14	M^a	55	businessman	Italian/Brazilian
15	F^a	57	housewife	Italian
16	F	64	housewife	Italian
17	M	58	farmer	Italian/Spanish
18	F	47	shoemaker	Italian/Brazilian
19	M^a	46	guard	Italian
20	M	63	businessman	Spanish
21	F	63	housewife	Italian
22	M^a	57	driver	Italian
23	M^a	50	vigilant	German
24	M^a a Bilateral disease.	51	banking	Italian/Chinese
25	M^a a Bilateral disease.	52	designer	Italian/Brazilian

Alleles	Dupuytren's contracture (N = 25)		Control group (N = 443)		p
Alleles	n	Fa (%)	n	Fa (%)	p
A*01	08	32.0	79	18.0	0.107
A*02	07	28.0	203	46.0	0.098
A*03	02	8.0	71	16.0	0.142
A*11	04	16.0	47	10.7	0.163
A*23	00	0.0	44	10.0	0.077
A*24	07	28.0	66	15.0	0.089
A*25	02	8.0	15	3.4	0.174
A*26	00	0.0	40	9.1	0.098
A*29	03	12.0	41	9.3	0.225
A*30	03	12.0	51	11.5	0.245
A*31	00	0.0	33	7.5	0.150
A*32	04	16.0	25	5.7	0.060
A*33	00	0.0	24	5.5	0.255
A*34	00	0.0	07	1.6	0.676
A*36	01	4.0	04	0.9	0.217
A*66	01	4.0	07	1.6	0.296
A*68	02	8.0	46	10.4	0.265
A*69	00	0.0	00	0.0	1.000
A*74	00	0.0	01	0.2	0.946
Blank	06	24.0	71	16.0	0.118

Alleles	Dupuytren's contracture (N = 25)		Control group (N = 443)		p
Alleles	n	Fa (%)	n	Fa (%)	p
B*07	01	4.0	57	13.0	0.122
B*08	05	20.0	50	11.3	0.099
B*13	01	4.0	10	2.3	0.346
B*18	08	32.0	46	10.5	0.003^a a Odds Ratio (OR): 4.02, Confidence Interval (IC 95%): 1.64-9.83, Pcorrected (Pc) = 0.11.
B*27	01	4.0	18	4.1	0.385
B*35	04	16.0	104	23.5	0.142
B*37	00	0.0	10	2.3	0.571
B*38	01	4.0	23	5.2	0.368
B*39	04	16.0	20	4.5	0.082
B*41	00	0.0	14	3.2	0.455
B*42	00	0.0	10	2.3	0.571
B*44	04	16.0	85	19.2	0.199
B*45	00	0.0	14	3.2	0.455
B*46	01	4.0	00	0.0	0.060
B*47	00	0.0	01	0.2	0.946
B*48	00	0.0	01	0.2	0.946
B*49	02	8.0	25	5.7	0.263
B*50	00	0.0	21	4.8	0.304
B*51	04	16.0	79	17.8	0.211
B*52	02	8.0	28	6.4	0.278
B*53	00	0.0	12	2.7	0.510
B*54	00	0.0	00	0.0	1.000
B*55	00	0.0	15	3.4	0.430
B*56	00	0.0	02	0.4	0.895
B*57	01	4.0	13	3.0	0.374
B*58	00	0.0	06	1.4	0.715
B*60	01	4.0	18	4.1	0.385
B*61	01	4.0	15	3.4	0.383
B*62	02	8.0	33	7.5	0.289
B*63	01	4.0	15	3.4	0.383
B*64	00	0.0	09	2.0	0.604
B*65	02	8.0	38	8.6	0.287
B*70	01	4.0	23	5.2	0.368
B*75	00	0.0	01	0.2	0.946
B*76	00	0.0	00	0.0	1.000
B*81	00	0.0	07	1.6	0.676
Blank	04	16.0	55	12.5	0.195

Alleles	Dupuytren's contracture (N = 25)		Control group (N = 443)		p
Alleles	n	Fa (%)	n	Fa (%)	p
DRB1*01	03	12.0	83	18.7	0.164
DRB1*04	05	20.0	85	19.2	0.200
DRB1*07	07	28.0	107	24.2	0.164
DRB1*08	03	12.0	55	12.4	0.244
DRB1*09	00	0.0	14	3.2	0.458
DRB1*10	00	0.0	22	5.0	0.290
DRB1*11	10	40.0	123	27.8	0.073
DRB1*12	00	0.0	14	3.2	0.458
DRB1*13	05	20.0	112	25.3	0.166
DRB1*14	02	8.0	34	7.7	0.289
DRB1*15	07	28.0	76	17.2	0.078
DRB1*16	02	8.0	32	7.2	0.287
DRB1*17	05	20.0	69	15.6	0.172
DRB1*18	01	4.0	10	2.3	0.344

Alleles	Dupuytren's contracture (n = 25)		Control group (n = 443)		p
Alleles	n	Fa (%)	n	Fa (%)	p
DQB1*02	12	48.0	180	40.7	0.125
DQB1*04	03	12.0	56	12.7	0.243
DQB1*05	09	36.0	154	34.8	0.167
DQB1*06	10	40.0	213	48.2	0.121
DQB1*07	11	44.0	147	33.2	0.090
DQB1*08	03	12.0	41	9.3	0.224
DQB1*09	02	8.0	12	2.7	0.135

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[1] M, male; F, female.

[t06-fn01] ^a
Bilateral disease.