Ozawa et al.1717 Ozawa N, Maruyama T, Nagashima T, Ono M, Arase T, Ishimoto H, Yoshimura Y. Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss. Fertil Steril. 2008; 90 (4): 1301-4.
|
2324 couples had a history of two or more consecutive pregnancy loss |
chromosome abnormalities: 114 couples 3.18% (74) reciprocal translocations, 0.99% (23) Robertsonian translocations (17 women, 0.73% and 6 men 0.26%), 0.43% (10) inversions and 0.39% (9) others 14 couples with normal variants (0.6%) and 81 with pericentric inversion 9 (3.49%) |
4.91% |
Kiss et al.1818 Kiss A, Rosa RF, Dibi RP, Zen PR, Pfeil JN, Graziadio C, Paskulin GA. Chromosomal abnormalities in couples with history of recurrent abortion. Rev Bras Ginecol Obstet. 2009; 31 (2): 68-74.
|
108 couples with history of two or more RMs |
chromosome abnormalities: 10 cases (5 women and 5 men) woman-man ratio 1:1 chromosomal analysis (normal results): 46,XX (n=100) and 46,XY (n=103) 5 structural alterations (30% of reciprocal translocation, 20% of Robertsonian translocation, 10% of chromosome inversion) and 5 numerical alterations (50% of mosaicism - sexual chromosomes) in one of the couples, the woman presented two concomitant alterations 3 polymorphisms (1.4%) |
9.3% |
Pal et al.1919 Pal S, Ma SO, Norhasimah M, Suhaida MA, Siti Mariam I, Ankathil R, Zilfalil BA. Chromosomal abnormalities and reproductive outcome in Malaysian couples with miscarriages. Singapore Med J. 2009; 50 (10): 1008-12.
|
56 couples who had two or more miscarriages |
five couples - chromosomal abnormality in one partner 4 cases - structural alterations (60% reciprocal translocations - women and 20% Robertsonian D/D translocations - men) 1 case - numerical abnormality (20% mosaic of Down syndrome - men) 60% (n=3) occurred in women and 40% (n=2) in men woman-man ratio 1.5:1 |
8.9% |
Dutta et al.2020 Dutta UR, Rajitha P, Pidugu VK, Dalal AB. Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in southern region of India: report and review. J Assist Reprod Genet. 2011; 28 (2): 145-9.
|
1162 couples with recurrent miscarriages |
chromosomal anomalies: 78 cases 1.41% (33) structural abnormalities [more frequent: 21 cases of balanced reciprocal translocations and 6 cases of Robertsonian translocations) -women (18 cases) and men (9 cases)] 1.89% (44) polymorphic variants (chromosome 9) 0.05% (1) numerical anomaly (mosaic XY/XXY) |
3.35% |
Niroumanesh et al.2121 Niroumanesh S, Mehdipour P, Farajpour A, Darvish S. A cytogenetic study of couples with repeated spontaneous abortions. Ann Saudi Med. 2011; 31 (1): 77-9.
|
100 couples with two or more miscarriages |
chromosome abnormalities: 13 cases chromosomal abnormalities: 8% women and 5% men woman-man ratio 1.6/1 4 (30.8%) balanced reciprocal translocations 3 (23%) Robertsonian translocations (D and G groups) 3 (23%) pericentric inversions (chromosomes 7 and 9) 1 (7.7%) paracentric inversion (chromosome 16) 1 (7.7%) chromosomal marker 1 (7.7%) polymorphism 9qh+ (woman who had a history of eight miscarriages and one live birth) inv(9) - one couple with a similar chromosomal abnormality |
12% |
Saxena et al.2222 Gada Saxena S, Desai K, Shewale L, Ranjan P, Saranath D. Chromosomal aberrations in 2000 couples of Indian ethnicity with reproductive failure. Reprod Biomed Online. 2012; 25 (2): 209-18.
|
955 couples with recurrent pregnancy loss |
chromosomal abnormalities: 49 cases 63.3% (31) reciprocal translocations (18 women and 13 men), 20.4% (10) Robertsonian translocations (7 women and 3 men), 10.2% (5) inversions, 2.04% (1) derivative chromosome, 2.04% (1) aneuploidy sexual chromosome, 2.04% (1) marker chromosome |
1.23% |
Gonsalves et al.2323 Gonçalves RO, Santos WV, Sarno M, Cerqueira BA, Gonçalves MS, Costa OL. Chromosomal abnormalities in couples with recurrent first trimester abortions. Rev Bras Ginecol Obstet. 2014; 36 (3): 113-7.
|
151 women and 94 partners (couples with two or more recur-ren t first trimester miscarriages) |
chromosome abnormalities: 13 cases (11 women and 2 partners) women: 4.7% X-chromosome mosaicism (n=7), 2% reciprocal translocations (n=3) and 0.6% Robertsonian translocations (n=1) men: 1% X-chromosome mosaicism (n=1) and 1% inversions (n=1) 3.65% structural alterations (n=5) and 5.75% numerical alterations (n=8) normal variations in the chromosomes structure: 4.6% (women, n=7) and 6.4% (men, n=6), more frequent: 9qh+ (9 cases) |
7.3% (woman) 2.1% (man) |
Karatas et al.2424 Karatas A, Eroz R, Albayrak M, Ozlu T, Cakmak B, Keskin F. Evaluation of chromosomal abnormalities and common trombophilic mutations in cases with recurrent miscarriage. Afr Health Sci. 2014; 14 (1): 216-22.
|
142 couples with recurrent miscarriage (≥2 pregnancy loss that occurred before the 20th gestational week) |
chromosome abnormalities: 33 cases (14 women and 19 men) woman-man ratio 0.7:1 chromosomal analysis (normal results): 46,XX (n=128) and 46,XY (n=123) women: 9 polymorphisms (64.3%), 3 translocations (21.4%) and 2 trisomy X (14.3%) men: 19 polymorphisms (100%) 28 polymorphisms: more frequent 1qh+ (n=9), 9qh+ (n=4) and 16qh+ (n=3) |
9.86% (woman) 13.4% (man) |
Ghazaey et al.1616 Ghazaey S, Keify F, Mirzaei F, Maleki M, Tootian S, Ahadian M, Abbaszadegan MR. Chromosomal analysis of couples with repeated spontaneous abortions in north-eastern iran. Int J Fertil Steril. 2015; 9 (1): 47-54.
|
728 couples with history of miscarriages ranging from 1-7 |
chromosomal abnormalities: 85 (48 women and 37 men) woman-man ratio 1.3:1 43.5% (37) reciprocal translocations (24 women and 13 men) 9.4% (8) Robertsonian translocations (4 women and 4 men) 8.3% (7) inversions 8.3% (7) numerical abnormalities 52 structural and 7 numerical abnormalities 30.5% (26) polymorphic variants |
11.7% |
Fan et al.2525 Fan HT, Zhang M, Zhan P, Yang X, Tian WJ, Li RW. Structural chromosomal abnormalities in couples in cases of recurrent spontaneous abortions in Jilin Province, China. Genet Mol Res. 2016; 15(1).
|
1948 couples with two or more recurrent miscarriages |
chromosomal abnormalities: 58 cases (20 men - 34.5% and 38 women -65.5%) women-men carriers ratio - approximately 2:1 types of structural chromosomal alterations: 72.4% (n=42) reciprocal translocations, 19% (n=11) Robertsonian translocations and 8.6% (n=5) pericentric inversions 42 reciprocal translocations (15 men - 35.7% and 27 women - 64.3% 11 Robertsonian translocations (3 men - 27.3% and 8 women - 72.3%) 5 inversions (2 men - 40% and 3 women - 60%) |
2.98% (structural chromosomal alterations) (1.95% woman and 1.03% man) |
Sudhir et al.2626 Sudhir N, Kaur T, Beri A, Kaur A. Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India. J Genet. 2016; 95 (4): 887-94.
|
440 couples with at least two consecutive miscarriages |
chromosomal abnormalities: 15 cases 53.3% (8) reciprocal translocations, 6.7% (1) Robertsonian translocation, 20% (3) duplications and inversion and 20% (3) polymorphic variants percentage of cases carrying translocations: 78% men and 22% women (man: woman ratio 1.5:1) |
3.41% |