OBJECTIVES: to evaluate the association of this malformation group and specific conditions of maternal health. METHODS: case control study with 274 individuals with cleft lip and palate and 548 hospital controls. The odd ratio (OR) and confidence intervals were obtained based on conditional logistic interval analysis. RESULTS: the main associations were maternal malformation reports (OR 8,01; 95%IC%: 2,23-28,81); gynecological infections (OR 2,77; 95%IC: 1,50-5,10); neurological conditions (OR 7,11; IC95%: 2,57-19,75); viruses (common cold for example) (OR 7,57; 95%IC: 2,46-23,32). In reproductive history no condition was demonstrated as being statistically significant, nevertheless, previous spontaneous abortions (OR 1,42; 95%IC: 0,95-2,13) and stillborns (OR 2,22; 95%IC: 0,88-5,65) demonstrated more pronounced risks. In addition to the use of anticonvulsant drugs (OR 20,00; 95%IC: 3,36-437,97), other drug groups were indicated as risk factors such as analgesics (OR 1,45; 95%IC: 1,08-1,95); antibiotics (OR 2,43; 95%IC: 1,33-4,57); antifungical drugs (OR 9,00; 95%IC: 2,14-61,12) and teas (OR 4,09; 95%IC: 2,23-7,77). CONCLUSIONS: together with exposures already described in the literature, including the use of anticonvulsant drugs, many others were identified. Although they may have been affected by possible mental confusion and forgetfulness that could have affected the results of this study, they should be evaluated and used as subsidies to more specific studies.
Cleft lip; Cleft palate; Pregnancy; Pharmaceutical preparations
