Post-extubation in clinical patients |
Hernandéz(8)8 Hernández G, Vaquero C, Colinas L, Cuena R, González P, Canabal A, et al. Effect of postextubation high-flow nasal cannula vs noninvasive ventilation on reintubation and postextubation respiratory failure in high-risk patients: a randomized clinical trial. JAMA. 2016;316(15):1565-74.
|
Yes |
NIV |
290 |
314 |
Re-intubation in 72 hours |
Fernandez(19)19 Fernandez R, Subira C, Frutos-Vivar F, Rialp G, Laborda C, Masclans JR, et al. High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial. Ann Intensive Care. 2017;7(1):47.
|
Yes |
Oxygen |
78 |
77 |
Respiratory failure in 72 hours |
Hernandéz(20)20 Hernández G, Vaquero C, Gonzáles P, Subira C, Frutos-Vivar F, Rialp G, et al. Effect of postextubation high-flow nasal cannula vs conventional oxygen therapy on reintubation in low-risk patients: a randomized clinical trial. JAMA. 2016;315(13):1354-61.
|
Yes |
Oxygen |
264 |
263 |
Re-intubation in 72 hours |
Maggiore(21)21 Maggiore SM, Idone FA, Vaschetto R, Festa R, Cataldo A, Antonicelli F, et al. Nasal high-flow versus Venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med. 2014;190(3):282-8.
|
Yes |
Oxygen |
53 |
52 |
PaO2 / FiO2 after 24 hours |
Post-extubation in surgical patients |
Brainard(11)11 Brainard J, Scott BK, Sullivan BL, Fernandez-Bustamante A, Piccoli JR, Gebbink MG, et al. Heated humidified high-flow nasal cannula oxygen after thoracic surgery. A randomized prospective clinical pilot trial. J Crit Care. 2017;40:225-8.
|
No |
Oxygen |
18 |
26 |
Pulmonary complications |
Ansari(15)15 Ansari BM, Hogan MP, Collier TJ, Baddeley RA, Scarci M, Coonar AS, et al. A randomized controlled trial of high flow nasal oxygen (Optiflow) as part of an enhanced recovery program after lung resection surgery. Ann Thorac Surg. 2016;101(2):459-64.
|
No |
Oxygen |
28 |
31 |
6 m walking test |
Corley(16)16 Corley A, Bull T, Spooner AJ, Barnett AG, Fraser JF. Direct extubation onto high-flow nasal cannulae post-cardiac surgery versus standard treatment in patients with a BMI = 30: a randomised controlled trial. Intensive Care Med. 2015;41(5):887-94.
|
No |
Oxygen |
81 |
74 |
Atelectasis on chest radiography |
Futier(17)17 Futier E, Paugam-Burtz C, Constantin JM, Pereira B, Jaber S. The OPERA trial - comparison of early nasal high flow oxygen therapy with standard care for prevention of postoperative hypoxemia after abdominal surgery: study protocol for a multicenter randomized controlled trial. Trials. 2013;14:341.
|
Yes |
Oxygen |
108 |
112 |
Hypoxemia |
Parke(18)18 Parke R, McGuinness S, Dixon R, Jull A. Open-label, phase II study of routine high-flow nasal oxygen therapy in cardiac surgical patients. Br J Anaesth. 2013;111(6):925-31.
|
No |
Oxygen |
169 |
171 |
SpO2 / FiO2 on third day |
Hypoxemic respiratory failure in clinical patients |
Frat(6)6 Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015;372(23):2185-96.
|
Yes |
NIV/Oxygen |
106 |
94 / 110 |
Need for MV in 28 days |
Rittayamai(7)7 Rittayamai N, Tscheikuna J, Rujiwit P. High-flow nasal cannula versus conventional oxygen therapy after endotracheal extubation: a randomized crossover physiologic study. Respir Care. 2014;59(4):485-90.
|
No |
Oxygen |
20 |
20 |
Dyspnea levels |
Azevedo(9)9 Azevedo JR, Montenegro WS, Leitao AL, Silva MM, Prazeres JS, Maranhao JP. High flow nasal cannula oxygen (HFNC) versus noninvasive positive pressure ventilation (NIPPV) in acute hypoxemic respiratory failure. A pilot randomized controlled trial. Intensive Care Med Exp. 2015;3(Suppl 1):A166.
|
No |
NIV |
14 |
16 |
Need for intubation |
Bell(10)10 Bell N, Hutchinson CL, Green TC, Rogan E, Bein KJ, Dinh MM. Randomised control trial of humidified high flow nasal cannulae versus standard oxygen in the emergency department. Emerg Med Australas. 2015;27(6):537-41.
|
Yes |
Oxygen |
48 |
52 |
Reduction in RR |
Parke(12)12 Parke RL, McGuinness SP, Eccleston ML. A preliminary randomized controlled trial to assess effectiveness of nasal high-flow oxygen in intensive care patients. Respir Care. 2011;56(3):267-70.
|
No |
Oxygen |
29 |
27 |
Not specified |
Jones(13)13 Jones PG, Kamona S, Doran O, Sawtell F, Wilsher M. Randomized controlled trial of humidified high-flow nasal oxygen for acute respiratory distress in the emergency department: the HOT-ER study. Respir Care. 2016;61(3):291-9.
|
No |
Oxygen |
165 |
138 |
Need for NIV or MV |
Lemiale(14)14 Lemiale V, Mokart D, Mayaux J, Lambert J, Rabbat A, Demoule A, et al. The effects of a 2-h trial of high-flow oxygen by nasal cannula versus Venturi mask in immunocompromised patients with hypoxemic acute respiratory failure: a multicenter randomized trial. Crit Care. 2015;19:380.
|
Yes |
Oxygen |
52 |
48 |
Need for NIV or MV |
Hypoxemic respiratory failure in surgical patients |
Stéphan et al.(5)5 Stéphan F, Barrucand B, Petit P, Rézaiguia-Delclaux S, Médard A, Delannoy B, Cosserant B, Flicoteaux G, Imbert A, Pilorge C, Bérard L; BiPOP Study Group. High-flow nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery: a randomized clinical trial. JAMA. 2015;313(23):2331-9.
|
Yes |
NIV |
414 |
416 |
Treatment failure |