Rhodes et al.(
99 Rhodes A, Wort SJ, Thomas H, Collinson P, Benett ED. Plasma DNA
concentration as a predictor of mortality and sepsis in critically ill patients. Crit
Care. 2006;10(2):R60.
)
|
Prospective observational |
19 |
Sepsis |
qPCR/ß-globin gene |
Nuclear |
Higher levels in patients who developed sepsis and in
patients who died in the ICU or in the hospital |
Saukkonen et al.(
1010 Saukkonen K, Lakkisto P, Pettilä V, Varpula M, Karlsson S, Ruokonen E,
Pulkki K; Finnsepsis Study Group. Cell-free plasma DNA as a predictor of outcome in
severe sepsis and septic shock. Clin Chem. 2008;54(6):1000-7.
)
|
Prospective observational |
255 |
Sepsis and septic shock |
qPCR/ß-globin gene |
Nuclear |
Higher levels in patients who died in the hospital |
Moreira et al.(
1111 Moreira VG, Prieto B, Rodríguez JS, Alvarez FV. Usefulness of cell-free
plasma DNA, procalcitonin and C-reactive protein as markers of infection in febrile
patients. Ann Clin Biochem. 2010;47(Pt 3):253-8.
)
|
|
110 |
Febrile |
|
Nuclear |
Levels correlated with the severity of infection |
Ha et al.(
1212 Ha TT, Huy NT, Murao LA, Lan NT, Thuy TT, Tuan HM, et al. Elevated
levels of cell-free circulating DNA in patients with acute dengue virus infection.
PLoS One. 2011;6(10):e25969.
)
|
Hospital-based case control |
192 |
Hemorrhagic dengue fever |
qPCR/GAPDH gene |
Nuclear |
Levels correlated with dengue severity and shock |
Huttunen et al.(
1313 Huttunen R, Kuparinen T, Jylhävä J, Aittoniemi J, Vuento R, Huhtala H,
et al. Fatal outcome in bacteremia is characterized by high plasma cell free DNA
concentration and apoptotic DNA fragmentation: a prospective cohort study. PLoS One.
2011; 6(7):e21700.
)
|
Prospective observational |
132 |
Bacteremia |
Quant-iT™ dsDNA HS assay |
Nuclear |
High levels were an independent risk factor for death |
Wijeratne et al.(
1414 Wijeratne S, Butt A, Burns S, Sherwood K, Boyd O, Swaminathan R.
Cell-free plasma DNA as a prognostic marker in intensive treatment unit patients. Ann
N Y Acad Sci. 2004;1022:232-8.
)
|
Prospective observational |
94 |
Prognosis prediction |
qPCR/ß-globin gene |
Nuclear |
Higher levels in patients who required mechanical
ventilation and non-survivors |
Saukkonen et al.(
1515 Saukkonen K, Lakkisto P, Varpula M, Varpula T, Voipio-Pulkki LM, Pettilä
V, et al. Association of cell-free plasma DNA with hospital mortality and organ
dysfunction in intensive care unit patients. Intensive Care Med.
2007;33(9):1624-7.
)
|
Prospective observational |
228 |
Prognosis prediction |
qPCR/ß-globin gene |
Nuclear |
The maximum level was an independent predictor of hospital
mortality |
Okkonen et al.(
1616 Okkonen M, Lakkisto P, Korhonen AM, Parviai-nen I, Reinikainen M,
Varpula T, Pettilä V; FINNALI Study Group. Plasma cell-free DNA in patients needing
mechanical ventilation. Crit Care. 2011;15(4):R196.
)
|
Prospective observational |
580 |
Prognosis prediction |
qPCR/ß-globin gene |
Nuclear |
Circulating DNA level at baseline was an independent
predictor of 90-day mortality |
Arnalich et al.(
1717 Arnalich F, Menéndez M, Lagos V, Ciria E, Quesada A, Codoceo R, et al.
Prognostic value of cell-free plasma DNA in patients with cardiac arrest outside the
hospital: an observational cohort study. Crit Care. 2010;14(2):R47.
)
|
Prospective observational |
85 |
Cardiac arrest |
qPCR/ß-globin gene |
Nuclear |
Higher levels at the time of admission in patients who died
at 24 h or in the hospital |
Huang et al.(
1818 Huang CH, Tsai MS, Hsu CY, Chen HW, Wang TD, Chang WT, et al.
Circulating cell-free DNA levels correlate with postresuscitation survival rates in
out-of-hospital cardiac arrest patients. Resuscitation.
2012;83(2):213-8.
)
|
Prospective observational |
42 |
Cardiac arrest |
qPCR//ß-globin gene |
Nuclear |
Independent predictor for in-hospital mortality and
associated with higher 90-day mortality |
Gornik et al.(
1919 GorniK I, Wagner J, Gasparovic V, Milicic D, Degoricija V, Skoric B, et
al. Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest
survivors at ICU admission and 24h post-admission. Resuscitation.
2014;85(2):233-7.
)
|
Prospective observational |
67 |
Cardiac arrest |
qPCR/human telomerase reverse transcriptase
gene |
Nuclear |
Level at 24 h after ICU admission was independently
associated with hospital mortality |
Gornik et al.(
2020 Gornik I, Wagner J, Gasparovic V, Lauc G, Gornik O. Free serum DNA is an
early predictor of severity in acute pancreatitis. Clin Biochem. 2009;
42(1-2):38-43.
)
|
Prospective observational |
30 |
Pancreatitis |
qPCR/human telomerase reverse transcriptase
gene |
Nuclear |
Higher levels on the first day correlated with extent of
necrosis and were a good predictor of severity |
Gornik et al.(
2121 Gornik O, Gornik I, Wagner J, Radic D, Lauc G. Evaluation of cell-free
DNA in plasma and serum as early predictors of severity in acute pancreatitis.
Pancreas. 2011;40(5):787-8.
)
|
Prospective observational |
104 |
Pancreatitis |
qPCR/human telomerase reverse transcriptase
gene |
Nuclear |
Higher levels on the first day correlated with
severity |
Nakahira et al.(
2222 Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, et al.
Circulating mitochondrial DNA in patients in the ICU as a marker of mortality:
derivation and validation. PLoS Med. 2013;10(12):e1001577; discussion
e1001577.
)
|
Prospective observational |
443 |
Prognosis prediction |
qPCR/human NADH dehydrogenase 1 gene |
Mitochondrial |
Higher levels associated with ICU mortality |