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Original Articles • Rev. Col. Bras. Cir. 36 (2) • Apr 2009 • https://doi.org/10.1590/S0100-69912009000200007 linkcopy

Open-access Immunohistochemical expression of HER-2/NEU-CERBB-2 in patients with adenocarcinoma of the stomach

Expressão imunoistoquímica do HER-2/NEU-CERBB-2 em pacientes com adenocarcinoma do estômago

    OBJECTIVES: To determine the prevalence of Her-2/Neu-cerbb-2 in the gastric mucosa of patients with gastric adenocarcinoma in a brazilian patient group. METHODS: The immunohistochemical expression of Her-2/Neu was studied in 37 formalin-fixed paraffin-embedded tissue sections. RESULTS: The immunohistochemical reaction produced by the anti-HER-2/Neu antibody was positive in two cases (5.4%). CONCLUSION: The low prevalence of Her-2/Neu observed in these southern brazilian cases is probably due to the great number of poorly differentiated cancers in this serie.

    Stomach neoplasms; Oncogenes; Immunohistochemistry

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