Acute pancreatitis has been the objective of discussion, principally regarding its physiopathology and treatment. It is recognized that pancreatic necrosis, infections and multiple organ dysfunction are associated with high mortality. This disease remains a challenge for physicians and surgeons. However, a better understanding of evolved mechanisms may be the key for an appropriated treatment, principally for severe forms of disease in which mortality remains elevated. This study reviews the physiopathology and natural history of severe acute pancreatitis, and its association to SIRS and sepsis.
Pancreatitis; Acute disease; Pancreatits; Acute necrotizing; Sepsis syndrome
