BACKGROUND: The effect of a corticotherapy on skin wound healing is conflitant in the literature. The objective of the our research was to compare the resistance of mice skin wound healing submitted to hydrocortisone administration, in different postoperative periods. METHOD: A skin incision and sutures were performed on 150 male mice. The animals were divided into five groups. The Group 1 (n=6) was assessed on resistance of the integre skin. The other groups (n=36) were submitted to incision on their dorsal skin. The Group 2 was submitted only to operation. The Group 3 received 0.9% saline solution. The groups 4 and 5 received 10 mg/kg/day local or sistemic hydrocortisone. The resistance of the wound healing and the weight variation were studied on the 7th and 21st postoperative days. RESULTS: The mice that received corticoid, groups 4 and 5, presented significant decreases on their weight (P<0,02). Groups 3, 4 and 5 showed lower resistance than Group 2 on the 7th postoperative day (p <0,02). On the 21st day, only the animals of the Group 3 (P<0,05) had lower resistance than the other groups. CONCLUSION: These results indicate a decreased of the wound healing resistance in the presence of corticosteroid only after a short time treatment.
Corticosteroids; Wound healing; Corticosteroid administration; Hydrocortisone
