BACKGROUND: The use of biological glue in surgery continues to be controversial in spite of the great number of investigations. The present work compared the rat skin graft healing submitted to suture and biological glue in different post-operative periods. METHODS: Two grafts in "U" were performed on the dorsal area of 10 male rats. One graft was sutured with 6-0 polipropilen thread, while the other was put together with biological glue of gelatin-resorcinol formaldeid (GRF). Half of the animals (n=5) were followed during an eight days period, and the other five were studied during 21 days. The macro and microscopic aspects of the skin healing were assessed. RESULTS: After eight days, the wound in presence of biologic glue showed more intense inflammation and an exuberant healing reaction. However, after 21 days, there was no difference between the cutaneous healing with 6-0 polipropilen and GRF glue. CONCLUSION: In the present study the biological glue was as good alternative for skin synthesis in rat as suture with polipropilen.
Suture; Biologic glue; Skin cicatrization
