BACKGROUND: The aim of this research was to study the effects of the use of fibrin adhesive with the surgical technique of submucosa invagination, in esophageal anastomosis. METHODS: Thirty two dogs operated on for esophageal anastomosis, were distributed in two groups: group I with encircling suture of twelve stitches, and group II with encircling suture of four stitches and fibrin sealant. The anastomosis was evaluated in the 7th and 14th post-operative day. Weight evolution, stenosis rate, presence of dehiscence and fistulae, presence of secretion around the anastomosis, presence of interstitial liquid, protean matrix, number of cells, fibroblasts, collagen fibers and the hydroxyproline concentration in the anastomosis were analysed. RESULTS: The stenosis rate was lower in the group I in the 7th post-operative day. The incidence of fistulae was significant in group II on the 7th day, as well as the presence of dehiscence, serosa secretion and suppurative secretion at the 7th and 14th day. Concerning hydroxyproline tissue concentration there was no statistical difference among the groups. The fibroblasts and collagen fibers were more numerous in group II at 14th day. There were four deaths in animals of group II. CONCLUSION: We concluded that anastomosis performed by submucosa-mucosa invagination with fibrin adhesive presented results less satisfactory than anastomosis performed with twelve encircling stitches.
Dogs; Esophagus; Fibrin adhesive; Surgical anastomosis
