This study brings some considerations about AIDS as an interdisciplinary and multiprofessional field of investigation. It discourses about the conceptions of monodisciplinarity, multidisciplinarity, pluridisciplinarity, interdisciplinarity and transdisciplinarity, reasoning about the biological, social, psychological and, specially, ethical and legal aspects that involve AIDS as a disease. It considers the incorporation of interdisciplinarity as a trend of the modern world at the end of this century and a great challenge for the collective health workers.