Diagnóstico precoce da infecção por HIV/Aids: análise de conceito

Duarte, Fernando Hiago da Silva; Silva, Silmara de Oliveira; Enders, Bertha Cruz; Lira, Ana Luisa Brandão de Carvalho; Dantas, Rodrigo Assis Neves; Dantas, Daniele Vieira

doi:10.1590/0034-7167-2022-0565pt

Fernando Hiago da Silva Duarte

contribuíram com a concepção ou desenho do estudo/pesquisa

contribuíram com a revisão final com participação crítica e intelectual no manuscrito

contribuíram com a análise e/ou interpretação dos dados

Universidade Federal do Rio Grande do Norte. Natal, Rio Grande do Norte, Brasil

https://orcid.org/0000-0002-2743-0452

Silmara de Oliveira Silva Autor Correspondente: Silmara de Oliveira Silva, E-mail: silmaraolyveira@gmail.com

contribuíram com a concepção ou desenho do estudo/pesquisa

contribuíram com a revisão final com participação crítica e intelectual no manuscrito

contribuíram com a análise e/ou interpretação dos dados

Universidade Federal do Rio Grande do Norte. Natal, Rio Grande do Norte, Brasil

https://orcid.org/0000-0002-2554-5045

Bertha Cruz Enders

contribuíram com a concepção ou desenho do estudo/pesquisa

contribuíram com a revisão final com participação crítica e intelectual no manuscrito

Universidade Federal do Rio Grande do Norte. Natal, Rio Grande do Norte, Brasil

https://orcid.org/0000-0001-5258-4579

Ana Luisa Brandão de Carvalho Lira

contribuíram com a concepção ou desenho do estudo/pesquisa

contribuíram com a revisão final com participação crítica e intelectual no manuscrito

Universidade Federal do Rio Grande do Norte. Natal, Rio Grande do Norte, Brasil

https://orcid.org/0000-0002-7255-960X

Rodrigo Assis Neves Dantas

contribuíram com a concepção ou desenho do estudo/pesquisa

contribuíram com a revisão final com participação crítica e intelectual no manuscrito

contribuíram com a análise e/ou interpretação dos dados

Universidade Federal do Rio Grande do Norte. Natal, Rio Grande do Norte, Brasil

https://orcid.org/0000-0002-9309-2092

Daniele Vieira Dantas

contribuíram com a concepção ou desenho do estudo/pesquisa

contribuíram com a revisão final com participação crítica e intelectual no manuscrito

Universidade Federal do Rio Grande do Norte. Natal, Rio Grande do Norte, Brasil

https://orcid.org/0000-0003-0307-2424

Autor Correspondente: Silmara de Oliveira Silva, E-mail: silmaraolyveira@gmail.com

EDITOR CHEFE: Álvaro Sousa

EDITOR ASSOCIADO: Luís Carlos Lopes-Júnior

Fontes de dados	Sintaxes de busca
BDENF	(HIV OR “Síndrome da imunodeficiência adquirida” OR “Vírus da Imunodeficiência Humana”) AND (“Diagnóstico precoce”) AND (“Unidades hospitalares” OR “serviços de saúde”)
Gale Academic Onefile	HIV OR Acquired Immunodeficiency Syndrome OR Human immunodeficiency vírus AND Palavra-chave: Early DiagnosisANDPalavra-chave: Hospital Units OR Health Services
Google Acadêmico	(HIV OR “Acquired Immunodeficiency Syndrom” OR “Human immunodeficiency vírus”) AND (“Early Diagnosis”) AND (“Hospital Units” OR “Health Services”)
LILACS	HIV OR “Síndrome da imunodeficiência adquirida” OR “Vírus da Imunodeficiência Humana” [Palavras] and “Diagnóstico precoce” [Palavras] and “Unidades hospitalares” OR “serviços de saúde” [Palavras]
MEDLINE/PubMed	((HIV OR “Acquired Immunodeficiency Syndrome” OR “Human immunodeficiency vírus”) AND (“Early Diagnosis”)) AND (“Hospital Units” OR “Health Services”)
SciELO	(^(HIV OR “Acquired Immunodeficiency Syndrome” OR “Human immunodeficiency vírus”)) AND ((“Early Diagnosis”)) AND ((“Hospital Units” OR “Health Services”))*
Scopus	TITLE-ABS-KEY (hiv OR “acquired immunodeficiency syndrome” OR “human immunodeficiency vírus”) AND TITLE-ABS-KEY (“early diagnosis”) AND TITLE-ABS-KEY (“hospital units” OR “health services”)
Web of Science	TS=(HIV OR Acquired Immunodeficiency Syndrome OR Human immunodeficiency vírus) AND TS=(Early Diagnosis) AND TS=(Hospital Units OR Health Services)

^* * ID - Identificação do artigo. ID	País/Ano	Título do artigo	Tipo de estudo
E1(⁹9 Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005;8(1):19-32. https://doi.org/10.1080/1364557032000119616 https://doi.org/10.1080/1364557032000119... )	Suécia/2000	Diagnosis of primary HIV-1 infection and duration of follow-up after HIV exposure	Estudo prospectivo
E2(¹⁰10 Lindbäck S, Thostensson R, Karlsson AC, Sydow MV, Flamholc L, Blaxhult A, et al. Diagnosis of primary HIV-1 infection and duration of follow-up after HIV exposure. AIDS [Internet]. 2000[cited 2022 Jun 10];14(15):2333-9. https://doi.org/10.1097/00002030-200010200-00014 https://doi.org/10.1097/00002030-2000102... )	Espanha/2009	Increasing Early Diagnosis of HIV through Rapid Testing in a Street Outreach Program in Spain	Estudo analítico
E3(¹¹11 Fuente L, Delgado J, Hoyos J, Belza MJ, Álvarez J, Gutiérrez J, et al. Increasing Early Diagnosis of HIV through Rapid Testing in a Street Outreach Program in Spain. AIDS Patient Care STDS. 2009;23(8):625-29. https://doi.org/10.1089/apc.2009.0019 https://doi.org/10.1089/apc.2009.0019... )	Estados Unidos da América (EUA)/2010	Routine Opt-Out Rapid HIV Screening and Detection of HIV Infection in Emergency Department Patients	Estudo prospectivo
E4(¹²12 Haukoos JS, Hopkins E, Conroy AA, Silverman M, Byyny RL, Eisert S, et al. Routine Opt-Out Rapid HIV Screening and Detection of HIV Infection in Emergency Department Patients. JAMA Network. 2010;304(3): 284-92. https://doi.org/10.1001/jama.2010.953 https://doi.org/10.1001/jama.2010.953... )	Espanha/2011	Assessment of an outreach street-based HIV rapid testing programme as a strategy to promote early diagnosis: a comparison with two surveillance systems in Spain, 2008-2011	Estudo comparativo
E5(¹³13 Belza MJ, Hoyos J, Balbuena SF, Bravo MJ, Fuente L. Assessment of an outreach street-based HIV rapid testing programme as a strategy to promote early diagnosis: a comparison with two surveillance systems in Spain, 2008-2011. Eurosurveillance. 2014;20(14):1-11. https://doi.org/10.2807/1560-7917.es2015.20.14.21089 https://doi.org/10.2807/1560-7917.es2015... )	Índia/2012	Feasibility and Effectiveness of Provider Initiated HIV Testing and Counseling of TB Suspects in Vizianagaram District, South India	Estudo transversal
E6(¹⁴14 Achanta S, Kumar AMV, Nagaraja SB, Jaju J, Rao S, Shamrao M, et al. Feasibility and effectiveness of provider initiated HIV testing and counseling of TB suspects in Vizianagaram district, South India. PLoS One. 2012;7(7):e41378. https://doi.org/10.1371/journal.pone.0041378 https://doi.org/10.1371/journal.pone.004... )	EUA/2014	Social Support as a Predictor of Early Diagnosis, Linkage, Retention, and Adherence to HIV Care: Results From The Steps Study	Estudo prospectivo observacional
E7(¹⁵15 Kelly JD, Hartman C, Graham J, Kallen MA, Giordano TP. Social Support as a Predictor of Early Diagnosis, Linkage, Retention, and Adherence to HIV Care: results from the steps study. J Assoc Nurses AIDS Care. 2014;25(5): 405-13. https://doi.org/10.1016/j.jana.2013.12.002 https://doi.org/10.1016/j.jana.2013.12.0... )	Quênia/2015	Stage of HIV presentation at initial clinic visit following a community-based HIV testing campaign in rural Kenya	Estudo comparativo
E8(¹⁶16 Haskew J, Turner K, Ro G, Ho A, Kimanga D, Sharif S. Stage of HIV presentation at initial clinic visit following a community-based HIV testing campaign in rural Kenya. BMC Public Health. 2015;15(16):1-7. https://doi.org/10.1186/s12889-015-1367-4 https://doi.org/10.1186/s12889-015-1367-... )	EUA/2017	Clinical and public health implications of acute and early HIV detection and treatment: a scoping review	Revisão de escopo
E9(¹⁷17 Rutstein SE, Ananworanich J, Fidler S, Johnson C, Sanders EJ, Sued O, et al. Clinical and public health implications of acute and early HIV detection and treatment: a scoping review. J Int AIDS Soc. 2017;20(1):1-13. https://doi.org/10.7448/IAS.20.1.21579 https://doi.org/10.7448/IAS.20.1.21579... )	Austrália/2018	Identifying missed clinical opportunities for the earlier diagnosis of HIV in Australia, a retrospective cohort data linkage study	Estudo retrospectivo
E10(¹⁸18 Mallitt KA, Wilson DP, Jansson J, McDonald A, Wand H, Post JJ. Identifying missed clinical opportunities for the earlier diagnosis of HIV in Australia, a retrospective cohort data linkage study. PLoS One. 2018;13(12): e0208323. https://doi.org/10.1371/journal.pone.0208323 https://doi.org/10.1371/journal.pone.020... )	Espanha/2018	The contribution of HIV point-of-care tests in early HIV diagnosis: community-based HIV testing monitoring in Catalonia, 1995 to 2018	Estudo descritivo
E11(¹⁹19 López LF, Urueña JR, Conway A, Saz J, Morales A, Quezadas J, et al. The contribution of HIV point-of-care tests in early HIV diagnosis: community-based HIV testing monitoring in Catalonia, 1995 to 2018. Eurosurveillance. 2018;25(43):1900424. https://doi.org/10.2807/1560-7917.ES.2020.25.43.1900424 https://doi.org/10.2807/1560-7917.ES.202... )	Estados Unidos/2018	Antibody detection by agglutination-PCR (ADAP) enables early diagnosis of HIV infection by oral fluid analysis	Ensaio clínico
E12(²⁰20 Tsai CT, Robinson PT, Cortez FJ, Elma MLB, Seftel D, Pourmandi N, et al. Antibody detection by agglutination-PCR (ADAP) enables early diagnosis of HIV infection by oral fluid analysis. Proc Natl Acad Sci. 2018;115(6):1250-5. https://doi.org/10.1073/pnas.1711004115 https://doi.org/10.1073/pnas.1711004115... )	Espanha/2019	Evaluación de un programa de salud pública sobre diagnostico de VIH con prueba rápida	Estudo descritivo
E13(²¹21 Gómez MAB, Soria OC, Blasco JB, Rodríguez IC, Riquelme FP, Piqueras OM. Evaluación de un programa de salud pública sobre diagnostico de VIH con prueba rápida. Rev Esp Salud Pública. [Internet]. 2019 [cited 2022 Jun. 03];93:e1-10. Available from: https://scielo.isciii.es/pdf/resp/v93/1135-5727-resp-93-e201912119.pdf https://scielo.isciii.es/pdf/resp/v93/11... )	EUA/2020	Identifying and predicting longitudinal trajectories of care for people newly diagnosed with HIV in South Africa	Estudo randomizado controlado
E14(²²22 Platt L, Xu A, Giddy J, Bogart LM, Boulle A, Parker RA, et al. Identifying and predicting longitudinal trajectories of care for people newly diagnosed with HIV in South Africa. PLoS One. 2020;15(9):e0238975. https://doi.org/10.1371/journal.pone.0238975 https://doi.org/10.1371/journal.pone.023... )	Espanha/2020	Recomendaciones dirigidas a los servicios de urgências para el diagnóstico precoz de pacientes con sospecha de infección por VIH y su derivación para estúdio y seguimento	Revisão de literatura
E15(²³23 Castillo JG, Putze GB, Cabello A, Curran A, Saavedra EJ, Malchair P, et al. Recomendaciones dirigidas a los servicios de urgencias para el diagnóstico precoz de pacientes con sospecha de infección por VIH y su derivación para estudio y seguimiento. Emergencias[Internet]. 2020 [cited 2022 Jun 03];32(6):416-26. Available from: https://dialnet.unirioja.es/servlet/articulo?codigo=7653890 https://dialnet.unirioja.es/servlet/arti... )	Reino Unido/2020	Evaluating the impact of post-trial implementation of RHIVA nurse-led HIV screening on HIV testing, diagnosis and earlier diagnosis in general practice in London, UK	Estudo pragmático
E16(²⁴24 Leber W, Griffiths JP, Martin P, Morris S, Barbosa EC, Estcourt C, et al. Evaluating the impact of post-trial implementation of RHIVA nurse-led HIV screening on HIV testing, diagnosis and earlier diagnosis in general practice in London, UK. EClinicalMedicine. 2020;19:100229. https://doi.org/10.1016/j.eclinm.2019.11.022 https://doi.org/10.1016/j.eclinm.2019.11... )	Holanda/2022	Testing and healthcare seeking behavior preceding HIV diagnosis among migrant and non-migrant individuals living in the Netherlands: Directions for early-case finding	Corte transversal

Elementos essenciais	^* * ID - identificação do artigo; †F - frequência absoluta; ‡% - Frequência relativa. ID	†F	‡%
Antecedentes
Comportamento de risco	E1, E2, E3, E4, E8, E9, E11, E12, E14, E15 e E16	19	12%
Informação	E1, E2, E4, E13, E15 e E16	18	11%
Drogas injetáveis	E2, E3, E4, E10, E12, E14, E15 e E16	10	6%
Relações sexuais desprotegidas	E1, E4, E8, E12, E14, E15 e E16	9	5,5%
Acesso ao serviço	E4, E5 e E9	4	2,5%
Prevenção	E3 e E8	3	2%
Consequentes
Tratamento antirretroviral	E1, E6, E7 E8, E9, E10 e E13	15	9,5%
Soroconversão	E1, E2, E8, E11 E12, E14 e E15	13	8%
Transmissão	E2, E4, E7, E8, E9, E12, E14, E15 e E16	11	6,8%
Consultas	E6, E7, E8, E10 e E15	10	6%
Aconselhamento	E5, E7, E8, E15 e E16	10	6%
Promoção da qualidade de vida	E1, E4, E5, E7 e E9	9	5,5%
Tratamento	E1, E4, E5 e E9	8	5%
Medicamento antirretroviral	E1, E2, E4, E6 e E7	7	4,3%
Paciente	E1, E2, E3, E4 e E8	6	3,8%
Inclusão social	E1, E2, E4, E6 e E7 e E10	6	3,8%
Doença crônica	E2, E4, E6 e E7	5	3,2%
Condutas sexuais	E1, E2, E4, E6 e E7	5	3,2%
Prevenção de doenças oportunistas	E1, E4, E5 e E9	4	2,5%
Exames	E2, E4 e E6	3	2%
Implicações econômicas	E2, E4 e E9	3	2%

[1] Autor Correspondente: Silmara de Oliveira Silva, E-mail: silmaraolyveira@gmail.com

Brasil

Brasil

Diagnóstico precoce da infecção por HIV/Aids: análise de conceito

RESUMO

Objetivos:

Métodos:

Resultados:

Considerações Finais: