Influence of the leukoreduction moment of blood components on the clinical outcomes of transfused patients in the emergency department

Influencia del momento de la leucorreducción de hemocomponentes en la evolución clínica de pacientes transfundidos en la emergencia

ABSTRACT

Objectives:

to investigate the influence of the leukoreduction moment (preor post-storage) of blood components on the clinical outcomes of patients transfused in the emergency department.

Methods:

retrospective cohort study of patients aged 18 years or older who received preor post-storage leukoreduced red blood cell or platelet concentrate in the emergency department and remained in the institution for more than 24 hours. A generalized mixed-effects model was applied in the analyses.

Results:

in a sample of 373 patients (63.27% male, mean age 54.83) and 643 transfusions (69.98% red blood cell), it was identified that the leukoreduction moment influenced the length of hospital stay (p<0.009), but was not dependent on the transfused blood component (p=0.124). The leukoreduction moment had no effect (p>0.050) on transfusion reactions, healthcare-associated infections, or mortality.

Conclusions:

patients who received pre-storage leukoreduced blood components in the emergency department had a shorter length of hospital stay.

Descriptors:
Blood Transfusion; Leukocyte Reduction Procedures; Transfusion Reaction; Clinical Evolution; Emergency Medical Service