Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia(1919 Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):1-9. https://doi.org/10.21037%2Ftp.2020.02.06 https://doi.org/10.21037%2Ftp.2020.02.06...
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2020 China |
Retrospective study 10 neonates |
Perinatal COVID-19 infection can harm newborns, leading to fetal distress, prematurity, respiratory issues, thrombocytopenia, and death. No evidence of vertical transmission was found. |
Clinical characteristics of 19 neonates born to mothers with COVID-19(2020 Liu W, Wang J, Li W, Zhou Z, Liu S, Rong Z. Clinical characteristics of 19 neonates born to mothers with COVID-19. Front Med. 2020;14(2):193-8. https://doi.org/10.1007%2Fs11684-020-0772-y https://doi.org/10.1007%2Fs11684-020-077...
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2020 China |
Cohort study n = 19 neonates |
Neonates showed no clinical, radiological, or hematological evidence of COVID-19, and no vertical transmission occurred during the third trimester. |
Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study(2121 Li N, Han L, Peng M, Lv Y, Ouyang Y, Liu K, et al. Maternal and neonatal outcomes of pregnant women with Coronavirus Disease 2019 (COVID-19) Pneumonia: a case-control study. Clin Infect Dis. 2020;71(16):2035-41. https://doi.org/10.1093/cid/ciaa352 https://doi.org/10.1093/cid/ciaa352...
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2020 China |
Cohort study n = 17 neonates |
Newborns did not contract COVID-19 or experience serious complications or respiratory failure during hospitalization. |
Neonatal Early-Onset Infection with SARS-CoV-2 in 33 Neonates Born to Mothers with COVID-19 in Wuhan, China(2222 Zeng L, Xia S, Yuan W. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. 2020;174(7):722-5. https://doi.org/10.1001/jamapediatrics.2020.0878 https://doi.org/10.1001/jamapediatrics.2...
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2020 China |
Cohort study n = 33 neonates |
Neonatal symptoms in COVID-19-exposed or at-risk infants were mild, with favorable outcomes. Vertical transmission couldn’t be ruled out despite negative test results. |
Vaginal delivery in SARS-CoV-2 infected pregnant women in Northern Italy: a retrospective analysis(2323 Ferrazzi E, Frigerio L, Savasi S, Vergani P, Prefumo F, Barresi S, et al. Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis. BJOG. 2020;127(9):1116-21. https://doi.org/10.1111/1471-0528.16278 https://doi.org/10.1111/1471-0528.16278...
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2020 Italy |
Retrospective multicenter study n = 42 neonates |
Some neonates tested positive for COVID-19, possibly due to postpartum contamination, suggesting low intrapartum transmission risk during vaginal delivery. |
Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care centre experience from India(2424 Anand P, Yadav A, Debata P, Bachani S, Gupta N, Gera R. Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care centre experience from India. Eur J Pediatr. 2021;180(2):547-59. https://doi.org/10.1007/s00431-020-03800-7 https://doi.org/10.1007/s00431-020-03800...
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2020 India |
Cohort study n = 65 neonates |
Seven out of 65 tested neonates had mild COVID-19, and maternal viral load did not correlate with newborn severity. |
A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society(2525 Oncel M, Akin I, Kanburoglu M, Tayman C, Coskun S, Narter F, et al. A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society. Eur J Pediatr. 2021;180(3):733-42. https://doi.org/10.1007/s00431-020-03767-5 https://doi.org/10.1007/s00431-020-03767...
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2020 Turkey |
Multicenter cohort n = 125 neonates |
Four out of 120 newborns tested positive for COVID-19, indicating significant impacts on perinatal and neonatal outcomes, including prematurity, cesarean section, suspected vertical transmission, and low breastfeeding rates. |
Clinical outcomes of maternal and neonate with COVID-19 infection-Multicenter study in Saudi Arabia(2626 Al-Matary A, Almatari F, Al-Matary M, Al-Dhaefi A, Alqahtani M, Alhulaimi E, et al. Clinical outcomes of maternal and neonate with COVID-19 infection; multicenter study in Saudi Arabia. J Infect Public Health. 2021;14(6):702-8. https://doi.org/10.1016/j.jiph.2021.03.013 https://doi.org/10.1016/j.jiph.2021.03.0...
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2021 Saudi Arabia |
Retrospective cohort study n = 200 neonates |
Most neonates had normal laboratory results, with few requiring NICU admission or respiratory support, and no cases of COVID-19 or evidence of vertical transmission. |
Clinical outcomes of COVID-19 positive mothers and their newborns - a retrospective study(2727 Silva D, Afonso A, Silva A, Silva A, Póvoas A. Clinical outcomes of COVID-19 positive mothers and their newborns: a retrospective study. Pediatr Oncall J. 2022;20(4):127-31. https://doi.org/10.7199/ped.oncall.2023.46 https://doi.org/10.7199/ped.oncall.2023....
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2022 Portugal |
Retrospective cohort study n = 52 neonates |
The study covered 865 deliveries, with few infants testing positive for SARS-CoV-2, and no fatal outcomes were observed, indicating unlikely perinatal or postnatal transmission. |
Clinical outcomes and antibody transfer in a cohort of infants with in utero or perinatal exposure to SARS-CoV-2 (Coronascope Study)(2828 Carrasco Colom J, Manzanares À, Gómez A, Escribano I, Esquivel E, Pérez-Rivilla A, et al. Clinical outcomes and antibody transfer in a cohort of infants with in utero or perinatal exposure to SARS-CoV-2 (Coronascope Study). Eur J Pediatr. 2023;182:4647-54 https://doi.org/10.1007/s00431-023-05147-1 https://doi.org/10.1007/s00431-023-05147...
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Espanha 2022 |
Observational prospective study n = 95 neonates |
Infants born to mothers with COVID-19 had normal neurological and auditory development, and most exhibited typical development in their first year of life, with only some showing positive serological results. |
Shortand mid-term multidisciplinary outcomes of newborns exposed to SARS-CoV-2 in utero or during the perinatal period: preliminary findings(2929 Buonsenso D, Costa S, Giordano L, Priolo F, Colonna A, Morini S. Short-and mid-term multidisciplinary outcomes of newborns exposed to SARS-CoV-2 in utero or during the perinatal period: preliminary findings. Eur J Pediatr. 2022;181:1507-20. https://doi.org/10.1007/s00431-021-04319-1 https://doi.org/10.1007/s00431-021-04319...
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Italy, 2022 |
Prospective study N: 199 newborns. |
The study encompassed various assessments, most newborns had normal growth and neurological development, and some showed potential effects of SARS-CoV-2 exposure. Overall, positive results were observed, except for some ophthalmological findings in a subset of cases |