Tendencia temporal de la incidencia de coinfección tuberculosis-VIH en Brasil, por macrorregión, Unidad Federativa, sexo y grupo de edad, 2010-2021

Lima, Lucas Vinícius de; Pavinati, Gabriel; Oliveira, Rosana Rosseto de; Couto, Rodrigo de Macedo; Alves, Kleydson Bonfim Andrade; Magnabosco, Gabriela Tavares

Lucas Vinícius de Lima

contributed to the concept and design of the study

analysis and interpretation of the results

drafting and critically reviewing the contents of the manuscript

approved the final version of the manuscript and are responsible for all aspects thereof

including the guarantee of its accuracy and integrity.

Universidade Estadual de Maringá, Programa de Pós-Graduação em Enfermagem, Maringá, PR, Brazil

https://orcid.org/0000-0002-9582-9641

Gabriel Pavinati

contributed to data analysis and interpretation

drafting and critically reviewing the contents of the manuscript

approved the final version of the manuscript and are responsible for all aspects thereof

including the guarantee of its accuracy and integrity.

Universidade Estadual de Maringá, Programa de Pós-Graduação em Enfermagem, Maringá, PR, Brazil

https://orcid.org/0000-0002-0289-8219

Rosana Rosseto de Oliveira

contributed to data analysis and interpretation

drafting and critically reviewing the contents of the manuscript

approved the final version of the manuscript and are responsible for all aspects thereof

including the guarantee of its accuracy and integrity.

Universidade Estadual de Maringá, Programa de Pós-Graduação em Enfermagem, Maringá, PR, Brazil

https://orcid.org/0000-0003-3373-1654

Rodrigo de Macedo Couto

contributed to data analysis and interpretation

drafting and critically reviewing the contents of the manuscript

approved the final version of the manuscript and are responsible for all aspects thereof

including the guarantee of its accuracy and integrity.

Universidade Federal de São Paulo, Escola Paulista de Enfermagem, São Paulo, SP, Brazil

https://orcid.org/0000-0003-2598-5830

Kleydson Bonfim Andrade Alves

contributed to data analysis and interpretation

drafting and critically reviewing the contents of the manuscript

approved the final version of the manuscript and are responsible for all aspects thereof

including the guarantee of its accuracy and integrity.

Organização Pan-Americana da Saúde, Departamento de Doenças Transmissíveis e Determinantes Ambientais da Saúde, Brasília, DF, Brazil

https://orcid.org/0000-0002-0905-3358

Gabriela Tavares Magnabosco

contributed to data analysis and interpretation

drafting and critically reviewing the contents of the manuscript

approved the final version of the manuscript and are responsible for all aspects thereof

including the guarantee of its accuracy and integrity.

Universidade Estadual de Maringá, Programa de Pós-Graduação em Enfermagem, Maringá, PR, Brazil

https://orcid.org/0000-0003-3318-6748

Correspondence: Lucas Vinícius de Lima | lvl.vinicius@gmail.com

CONFLICTS OF INTEREST

The authors have no conflicts of interest to declare.

Associate editor:

Carolina Fausto de Souza Coutinho

Federative Units (by macro-region)		2010	2011	2012	2013	2014	2015	2016	2017	2018	2019	2020	2021
North	Rondônia	4.9	7.2	6.8	7.7	8.6	6.9	9.6	8.0	6.2	6.9	5.4	4.1
	Acre	4.1	3.7	4.5	3.0	3.0	2.4	2.2	2.7	2.3	4.2	1.8	2.7
	Amazonas	18.6	16.0	17.4	21.5	25.3	25.9	23.1	24.6	21.8	21.9	18.6	12.7
	Roraima	8.9	5.4	6.4	9.1	3.9	7.5	5.3	7.2	5.5	7.3	8.5	7.5
	Pará	8.7	8.3	7.9	8.5	8.6	9.0	8.6	10.3	9.4	11.0	9.7	5.1
	Amapá	3.3	3.6	4.7	2.9	4.2	3.6	4.2	5.5	5.4	6.2	4.3	5.0
	Tocantins	2.0	1.2	1.2	1.4	2.4	1.5	1.9	1.6	2.3	1.9	1.8	2.9
Northeast	Maranhão	5.0	4.8	5.5	5.8	5.1	5.7	5.6	5.9	7.0	6.8	6.0	4.8
	Piauí	3.2	3.8	4.0	2.6	4.1	2.4	3.6	3.6	4.1	3.7	3.1	2.5
	Ceará	5.3	6.8	7.9	6.8	6.9	7.5	6.8	7.6	7.6	8.6	7.4	5.6
	Rio Grande do Norte	5.3	6.2	8.2	7.5	7.1	7.1	5.3	7.2	8.5	8.1	7.6	5.0
	Paraíba	5.8	5.5	5.5	6.6	6.2	5.6	4.4	5.9	6.4	6.0	5.9	4.8
	Pernambuco	12.2	13.4	14.8	13.8	13.6	13.6	14.2	13.8	13.6	12.7	11.6	8.7
	Alagoas	6.0	6.6	8.2	8.8	7.3	5.9	9.5	9.1	9.1	9.6	7.6	5.2
	Sergipe	3.7	4.1	3.3	4.7	4.4	3.4	4.2	4.4	6.7	5.4	5.9	3.8
	Bahia	5.7	5.8	5.1	5.6	5.5	5.3	5.2	5.1	5.0	5.1	4.4	3.7
Southeast	Minas Gerais	3.4	4.1	3.9	4.1	4.1	3.6	3.3	3.2	3.3	3.5	3.0	1.9
	Espírito Santo	5.7	5.2	6.1	5.7	5.1	5.6	4.3	4.4	5.5	4.9	6.4	6.7
	Rio de Janeiro	15.9	16.9	16.6	15.0	15.4	15.8	14.8	14.6	15.2	14.8	12.8	9.5
	São Paulo	9.3	9.4	8.8	9.0	8.8	8.4	7.8	8.0	8.3	7.9	6.8	5.0
South	Paraná	6.0	5.4	5.4	5.6	5.5	5.3	4.7	4.3	4.5	3.7	3.9	3.2
	Santa Catarina	12.3	14.1	11.9	11.9	11.9	11.0	9.8	10.0	8.9	8.3	6.1	4.6
	Rio Grande do Sul	23.1	24.2	25.0	24.2	23.8	22.9	21.2	20.1	18.8	18.6	16.6	12.0
Midwest	Mato Grosso do Sul	6.6	7.4	8.8	8.8	7.9	6.6	6.6	6.8	8.0	9.6	9.3	6.5
	Mato Grosso	7.1	6.9	5.2	6.8	6.5	6.7	8.8	8.0	6.8	6.0	5.3	3.8
	Goiás	3.1	3.3	4.1	3.3	3.1	3.9	3.2	3.8	3.3	2.3	2.6	2.0
	Distrito Federal	2.1	3.1	3.5	3.0	4.2	2.9	3.1	3.2	2.9	3.2	2.8	2.1

Macro-regions and Federative Units	Period	APC^a (95%CI^b)	AAPCc (95%CI^b)
North	2010-2019	3.1 (1.0;6.8)^d	-2.4 (-7.1;0.1)
North	2019-2021	-23.7 (-64.3;-8.4)^d	-2.4 (-7.1;0.1)
Rondônia	2010-2016	6.7 (1.4;17.4)^d	-2.4 (-7.1;0.7)
Rondônia	2016-2021	-12.4 (-29.1;-7.2)^d	-2.4 (-7.1;0.7)
Acre	2010-2016	-11.2 (-17.4;-8.3)^d	-7.1 (-10.0;-5.0)^d
	2016-2019	13.4 (-6.0;22.1)
	2019-2021	-21.1 (-34.9;0.2)
Amazonas	2010-2015	9.5 (-6.4;37.4)	-1.7 (-4.7;2.1)
	2015-2019	-3.8 (-9.2;21.9)
	2019-2021	-21.6 (-36.2;-8.0)^d
Roraima	2010-2017	-2.4 (-16.9;1.9)	1.5 (-1.2;3.9)
Roraima	2017-2021	8.8 (0.6;29.6)^d	1.5 (-1.2;3.9)
Pará	2010-2019	3.4 (2.0;5.9)^d	-1.6 (-3.4;0.6)
Pará	2019-2021	-21.3 (-30.3;-7.4)^d	-1.6 (-3.4;0.6)
Amapá	2010-2015	0.0 (-15.0;5.2)	1.7 (-1.3;3.6)
	2015-2018	17.0 (7.9;25.7)^d
	2018-2021	-9.1 (-26.1;-1.9)^d
Tocantins	2010-2021	4.1 (0.1;8.6)^d	4.1 (0.1;8.6)^d
Northeast	2010-2019	1.3 (0.2;3.0)^d	-2.2 (-3.5;-1.0)^d
Northeast	2019-2021	-16.8 (-22.9;-8.7)^d	-2.2 (-3.5;-1.0)^d
Maranhão	2010-2016	2.1 (-4.1;4.3)	-0.4 (-1.7;0.7)
	2016-2019	7.6 (3.9;10.8)^d
	2019-2021	-17.5 (-23.5;-9.2)^d
Piauí	2010-2015	-4.6 (-13.5;-1.5)^d	-3.4 (-6.1;-2.2)^d
	2015-2018	11.1 (2.8;17.4)^d
	2018-2021	-14.4 (-30.9;-7.8)^d
Ceará	2010-2019	3.1 (1.1;13.2)^d	-0.7 (-3.2;2.6)
Ceará	2019-2021	-16.2 (-28.7;-0.8)^d	-0.7 (-3.2;2.6)
Rio Grande do Norte	2010-2021	0.7 (-3.3;5.4)	0.7 (-3.3;5.4)
Paraíba	2010-2021	-0.4 (-2.6;1.9)	-0.4 (-2.6;1.9)
Pernambuco	2010-2012	7.3 (1.0;16.1)^d	-2.8 (-4.2;-1.4)^d
	2012-2018	-1.0 (-2.6;0.3)
	2018-2020	-17.5 (-23.8;-11.1)^d
Alagoas	2010-2019	4.3 (1.8;11.6)^d	-1.8 (-5.3;2.3)
Alagoas	2019-2021	-25.3 (-40.2;-5.1)^d	-1.8 (-5.3;2.3)
Sergipe	2010-2021	4.0 (1.2;7.2)^d	4.0 (1.2;7.2)^d
Bahia	2010-2019	-1.4 (-1.8;-0.8)^d	-3.6 (-4.2;-3.1)^d
Bahia	2019-2021	-13.1 (-16.2;-8.2)^d	-3.6 (-4.2;-3.1)^d
Southeast	2010-2019	-1.7 (-2.4;-0.7)^d	-4.6 (-5.6;-3.8)^d
Southeast	2019-2021	-16.9 (-21.9;-10.1)^d	-4.6 (-5.6;-3.8)^d
Minas Gerais	2010-2019	-1.5 (-7.7;24.0)	-5.8 (-10.1;-0.3)^d
Minas Gerais	2019-2021	-22.8 (-42.4;-0.8)^d	-5.8 (-10.1;-0.3)^d
Espírito Santo	2010-2013	2.0 (-1.8;12.0)	1.9 (0.9;3.3)^d
	2013-2017	-6.5 (-11.3;-3.2)^d
	2017-2021	11.1 (6.7;19.1)^d
Rio de Janeiro	2010-2019	-1.2 (-1.9;-0.2)^d	-4.4 (-5.5;-3.6)^d
Rio de Janeiro	2019-2021	-17.6 (-23.0;-10.6)^d	-4.4 (-5.5;-3.6)^d
São Paulo	2010-2016	-2.7 (-5.9;-1.6)^d	-5.4 (-6.2;-4.8)^d
	2016-2019	0.2 (-1.9;2.0)
	2019-2021	-20.3 (-24.2;-14.3)^d
South	2010-2014	-0.9 (-2.3;2.4)	-6.2 (-6.9;-5.5)^d
	2014-2019	-5.8 (-7.1;-4.4)^d
	2019-2021	-16.5 (-20.5;-12.2)^d
Paraná	2010-2014	-0.5 (-3.0;5.0)	-4.4 (-5.4;-3.4)^d
Paraná	2014-2021	-6.5 (-9.1;-5.4)^d	-4.4 (-5.4;-3.4)^d
Santa Catarina	2010-2014	-3.2 (-4.7;0.6)	-9.3 (-10.1;-8.5)^d
	2014-2019	-6.5 (-8.6;-5.1)^d
	2019-2021	-26.1 (-29.9;-19.5)^d
Rio Grande do Sul	2010-2012	5.0 (-0.4;10.2)	-5.2 (-6.3;-4.4)^d
	2012-2019	-4.3 (-5.4;-3.4)^d
	2019-2021	-17.3 (-22.1;-11.7)^d
Midwest	2010-2018	0.7 (-0.4;2.1)	-2.6 (-3.9;-1.7)^d
Midwest	2018-2021	-10.9 (-20.2;-6.5)^d	-2.6 (-3.9;-1.7)^d
Mato Grosso do Sul	2010-2021	0.7 (-4.7;6.9)	0.7 (-4.7;6.9)
Mato Grosso	2010-2012	-12.0 (-19.7;0.4)	-5.1 (-6.9;-3.3)^d
	2012-2017	8.0 (4.2;16.7)^d
	2017-2021	-16.1 (-23.4;-11.3)^d
Goiás	2010-2017	0.8 (-2.2;15.7)	-4.5 (-8.6;-0.6)^d
Goiás	2017-2021	-13.0 (-36.1;-6.0)^d	-4.5 (-8.6;-0.6)^d
Distrito Federal	2010-2012	26.7 (4.4;48.3)^d	1.4 (-1.4;4.0)
Distrito Federal	2012-2021	-3.5 (-7.1;-1.9)^d	1.4 (-1.4;4.0)
B razil	2010-2019	-1.0 (-1.6;-0.2)^d	-4.3 (-5.1;-3.7)^d
B razil	2019-2021	-18.0 (-22.1;-11.7)^d	-4.3 (-5.1;-3.7)^d

Macro-regions and Federative Units	Female			Male
Macro-regions and Federative Units	Period	APC ^a (95%CI ^b )	AAPC ^c (95%CI ^b )	Period	APC ^a (95%CI ^b )	AAPC ^c (95%CI ^b )
North	2010-2019	1.3 (-0.9;7.7)	-3.5 (-8.4;0.0)	2010-2014	7.2 (3.2;37.2)^d	-0.2 (-2.7;2.0)
	2019-2021	-22.5 (-64.0;-4.6)^d	-3.5 (-8.4;0.0)	2014-2019	1.5 (-3.2;5.2)
	–	–	–	2019-2021	-17.4 (-44.3;-10.2)^d
Rondônia	2010-2018	1.8 (-2.2;11.8)	-6.6 (-13.0;-2.0)^d	2010-2015	11.7 (3.3;47.7)^d	-0.8 (-5.8;5.4)
Rondônia	2018-2021	-25.8 (-55.4;-9.6)^d	-6.6 (-13.0;-2.0)^d	2015-2021	-10.1 (-25.9;-5.0)^d	-0.8 (-5.8;5.4)
Acre	2010-2013	-44.3 (-72.9;-21.4)^d	-15.8 (-27.6;-9.0)^d	2010-2021	-2.9 (-7.7;1.6)	-2.9 (-7.7;1.6) – –
	2013-2016	34.2 (0.1;74.0)^d		–	–
	2016-2021	-18.4 (-66.8;-2.1)^d		–	–
Amazonas	2010-2017	4.1 (0.4;14.4)^d	-2.8 (-7.0;0.9)	2010-2015	11.7 (5.6;31.3)^d	1.8 (-1.2;5.8)
Amazonas	2017-2021	-13.8 (-35.0;-6.1)^d	-2.8 (-7.0;0.9)	2015-2021	-5.8 (-14.0;-1.9)^d	1.8 (-1.2;5.8)
Roraima	2010-2021	-5.1 (-11.4;1.3)	-5.1 (-11.4;1.3)	2010-2021	1.8 (-4.1;9.0)	1.8 (-4.1;9.0)
Pará	2010-2021	-0.1 (-2.7;2.7)	-0.1 (-2.7;2.7) – –	2010-2016	1.4 (-4.8;3.2)	-2.6 (-4.2;-1.5)^d
	–	–		2016-2019	10.4 (5.5;14.4)^d
	–	–		2019-2021	-28.6 (-35.1;-22.2)^d
Amapá	2010-2021	-0.9 (-8.5;8.3)	-0.9 (-8.5;8.3)	2010-2018	8.6 (6.5;22.4)^d	5.6 (3.3;8.7)^d
Amapá	–	–	–	2018-2021	-2.2 (-16.6;5.4)	5.6 (3.3;8.7)^d
Tocantins	2010-2021	3.0 (-6.6;15.4)	3.0 (-6.6;15.4)	2010-2021	4.2 (-3.3;13.4)	4.2 (-3.3;13.4)
Northeast	2010-2019	0.7 (-0.7;3.7)	-3.3 (-5.6;-1.3)^d	2010-2019	1.5 (0.6;3.0)^d	-1.5 (-2.6;-0.4)^d
Northeast	2019-2021	-19.6 (-31.2;-7.5)^d	-3.3 (-5.6;-1.3)^d	2019-2021	-13.9 (-19.8;-6.4)^d	-1.5 (-2.6;-0.4)^d
Maranhão	2010-2021	3.3 (1.3;5.6)^d	3.3 (1.3;5.6)^d	2010-2021	2.5 (1.3;3.7)^d	2.5 (1.3;3.7)^d
Piauí	2010-2018	0.4 (-4.1;40.8)	-5.4 (-11.4;1.7)	2010-2015	-4.8 (-12.4;-1.8)^d	-3.7 (-5.9;-1.9)^d
	2018-2021	-19.1 (-48.7;-4.1)^d	-5.4 (-11.4;1.7)	2015-2019	9.7 (4.4;19.5)^d
	–	–	–	2019-2021	-23.3 (-34.3;-9.9)^d
Ceará	2010-2012	15.8 (5.6;27.3)^d	-1.3 (-3.3;0.5)	2010-2021	1.0 (-1.8;4.2)	1.0 (-1.8;4.2)
	2012-2019	2.4 (-0.4;4.4)		–	–	–
	2019-2021	-26.1 (-33.3;-15.8)^d		–	–	–
Rio Grande do Norte	2010-2021	-2.0 (-8.8;5.4)	-2.0 (-8.8;5.4)	2010-2021	1.4 (-1.3;4.6)	1.4 (-1.3;4.6)
Paraíba	2010-2021	-2.8 (-7.1;1.5)	-2.8 (-7.1;1.5)	2010-2021	0.5 (-1.8;3.0)	0.5 (-1.8;3.0)
Pernambuco	2010-2012	9.3 (1.6;16.5)^d	-3.4 (-4.9;-2.1)	2010-2018	1.3 (-0.4;4.3)	-2.7 (-4.5;-1.1)^d
	2012-2019	-2.3 (-4.1;-0.9)^d		2018-2021	-12.6 (-22.7;-6.1)^d	-2.7 (-4.5;-1.1)^d
	2019-2021	-17.9 (-24.3;-9.9)^d		–	–	–
Alagoas	2010-2019	3.0 (-8.9;55.6)	-3.0 (-9.2;7.1)	2010-2018	6.2 (3.1;14.6)^d	-0.2 (-3.8;3.5)
Alagoas	2019-2021	-25.8 (-51.4;5.8)	-3.0 (-9.2;7.1)	2018-2021	-15.4 (-35.2;-4.3)^d	-0.2 (-3.8;3.5)
Sergipe	2010-2021	3.3 (-2.1;9.9)	3.3 (-2.1;9.9)	2010-2021	3.9 (0.4;7.9)^d	3.9 (0.4;7.9)^d
Bahia	2010-2012	-14.2 (-17.5;-7.2)^d	-5.3 (-6.3;-4.3)^d	2010-2013	1.3 (0.1;4.1)^d	-3.1 (-3.5;-2.8)^d
	2012-2019	1.2 (0.3;3.5)^d		2013-2019	-2.5 (-3.0;-1.8)^d
	2019-2021	-16.8 (-22.3;-9.9)^d		2019-2021	-11.4 (-13.3;-7.9)^d
Southeast	2010-2019	-3.1 (-4.1;-0.2)^d	-5.6 (-7.4;-3.9)^d	2010-2019	-1.2 (-1.8;-0.5)^d	-4.3 (-5.0;-3.6)^d
Southeast	2019-2021	-16.5 (-25.4;-6.0)^d	-5.6 (-7.4;-3.9)^d	2019-2021	-16.8 (-20.9;-10.5)^d	-4.3 (-5.0;-3.6)^d
Minas Gerais	2010-2012	11.9 (-10.0;45.2)	-8.1 (-14.0;-3.5)^d	2010-2021	-2.4 (-4.8;0.0)	-2.4 (-4.8;0.0) – –
	2012-2019	-6.1 (-17.4;7.6)		–	–
	2019-2021	-29.9 (-51.7;-4.3)^d		–	–
Espírito Santo	2010-2013	14.5 (9.4;28.9)^d	2.6 (1.4;4.2)^d	2010-2017	-3.2 (-6.0;-1.5)^d	1.2 (0.0;2.3)
	2013-2016	-17.3 (-20.9;-10.3)^d		2017-2021	9.5 (4.7;19.2)^d	1.2 (0.0;2.3)
	2016-2021	9.4 (5.9;16.0)^d		–	–	–
Rio de Janeiro	2010-2019	-2.7 (-6.4;8.5)	-4.6 (-6.7;-2.0)^d	2010-2019	-0.7 (-1.3;0.1)	-4.3 (-5.4;-3.7)^d
Rio de Janeiro	2019-2021	-12.8 (-23.8;-2.1)^d	-4.6 (-6.7;-2.0)^d	2019-2021	-19.2 (-24.3;-12.1)^d	-4.3 (-5.4;-3.7)^d
São Paulo	2010-2016	-4.6 (-7.5;-3.8)^d	-6.7 (-7.6;-6.1)^d	2010-2019	-1.5 (-2.2;-0.6)^d	-4.8 (-5.8;-4.0)^d –
	2016-2019	0.6 (-2.2;2.5)		2019-2021	-18.4 (-23.5;-11.2)^d
	2019-2021	-21.9 (-26.4;-16.6)^d		–	–
South	2010-2013	3.2 (0.8;6.9)^d	-5.8 (-6.6;-5.2)^d	2010-2014	-1.7 (-4.7;5.9)	-6.3 (-7.5;-5.2)^d
	2013-2019	-5.4 (-6.3;-4.4)^d		2014-2019	-5.8 (-7.5;-2.3)^d
	2019-2021	-18.8 (-22.6;-13.8)^d		2019-2021	-15.9 (-22.4;-9.5)^d
Paraná	2010-2015	1.4 (-1.5;6.3)	-6.2 (-7.8;-5.0)^d	2010-2014	-2.0 (-3.9;4.4)	-4.0 (-5.3;-3.1)^d
Paraná	2015-2021	-12.2 (-16.2;-10.0)^d	-6.2 (-7.8;-5.0)^d	2014-2021	-5.1 (-12.2;-4.2)^d	-4.0 (-5.3;-3.1)^d
Santa Catarina	2010-2016	-4.3 (-7.4;2.2)	-10.0 (-11.6;-8.9)^d	2010-2018	-4.4 (-5.8;-2.7)^d	-8.7 (-10.7;-7.4)^d –
	2016-2019	-8.0 (-10.3;-3.0)^d		2018-2021	-19.0 (-31.9;-13.0)^d
	2019-2021	-27.7 (-35.4;-20.1)^d		–	–
Rio Grande do Sul	2010-2013	4.9 (4.0;5.7)^d	-4.3 (-4.7;-3.9)^d	2010-2012	3.6 (-5.6;15.4)	-5.6 (-7.8;-3.7)^d
	2013-2019	-4.7 (-5.1;-4.2)^d		2012-2019	-4.6 (-7.7;0.1)
	2019-2021	-15.5 (-17.6;-11.3)^d		2019-2021	-17.1 (-27.2;-7.7)^d
Midwest	2010-2016	0.6 (-1.3;3.5)	-3.9 (-5.4;-3.0)^d	2010-2014	0.9 (-3.4;2.6)	-3.5 (-4.3;-3.0)^d
	2016-2021	-9.2 (-14.5;-6.6)^d	-3.9 (-5.4;-3.0)^d	2014-2017	5.8 (2.9;7.9)^d
	–	–	–	2017-2021	-13.9 (-16.2;-12.4)^d
Mato Grosso do Sul	2010-2021	-0.6 (-5.8;4.9)	-0.6 (-5.8;4.9)	2010-2021	1.3 (-3.0;6.3)	1.3 (-3.0;6.3)
Mato Grosso	2010-2017	0.1 (-3.7;19.2)	-4.5 (-9.2;-0.7)^d	2010-2013	-7.0 (-19.7;0.2)	-4.6 (-6.8;-3.2)^d
	2017-2021	-12.2 (-37.5;-4.3)^d	-4.5 (-9.2;-0.7)^d	2013-2017	12.8 (6.6;22.6)^d
	–	–	–	2017-2021	-17.9 (-26.3;-12.7)^d
Goiás	2010-2017	1.3 (-1.6;6.7)	-4.9 (-7.8;-2.7)^d	2010-2017	0.6 (-2.4;21.1)	-4.4 (-8.6;-0.1)^d
Goiás	2017-2021	-14.8 (-30.8;-8.4)^d	-4.9 (-7.8;-2.7)^d	2017-2021	-12.5 (-36.2;-5.5)^d	-4.4 (-8.6;-0.1)^d
Distrito Federal	2010-2018	-8.2 (-25.0;5.4)	-3.3 (-8.0;-0.2)^d	2010-2012	29.9 (11.4;48.5)^d	0.1 (-2.7;2.6)
	2018-2021	10.9 (-6.8;45.0)	-3.3 (-8.0;-0.2)^d	2012-2019	-0.9 (-3.1;1.6)
	–	–	–	2019-2021	-20.1 (-30.7;-8.4)^d
B razil	2010-2019	-1.8 (-2.6;-0.9)^d	-5.4 (-6.5;-4.6)^d	2010-2019	-0.7 (-1.2;-0.1)^d	-4.0 (-4.6;-3.4)^d
B razil	2019-2021	-19.8 (-25.4;-12.9)^d	-5.4 (-6.5;-4.6)^d	2019-2021	-17.3 (-20.8;-11.2)^d	-4.0 (-4.6;-3.4)^d

Macro-regions and Federative Units	18-34 years			35-59 years
Macro-regions and Federative Units	Period	APC ^a (95%CI ^b )	AAPC ^c (95%CI ^b )	Period	APC ^a (95%CI ^b )	AAPC ^c (95%CI ^b )
North	2010-2019	2.8 (0.3;9.1)^d	-2.9 (-7.3;0.6)	2010-2014	7.2 (4.5;15.9)^d	-2.5 (-3.6;-1.1)^d
	2019-2021	-24.9 (-45.7;-6.4)^d	-2.9 (-7.3;0.6)	2014-2019	0.1 (-2.5;2.6)
	–	–	–	2019-2021	-24.7 (-30.0;-16.0)^d
Rondônia	2010-2016	5.7 (1.3;15.9)^d	-2.6 (-6.3;0.4)	2010-2012	26.3 (10.0;43.5)^d	-1.1 (-3.6;0.9)
	2016-2021	-11.6 (-26.3;-6.5)^d	-2.6 (-6.3;0.4)	2012-2017	1.7 (-5.6;5.4)
	–	–	–	2017-2021	-15.5 (-25.4;-11.3)^d
Acre	2010-2021	-4.9 (-9.1;-1.3)^d	-4.9 (-9.1;-1.3)^d	2010-2021	-3.6 (-10.5;3.1)	-3.6 (-10.5;3.1)
Amazonas	2010-2017	5.7 (1.3;40.1)^d	-1.1 (-6.8;5.3)	2010-2015	11.1 (0.3;29.7)^d	-1.6 (-4.0;1.3)
	2017-2021	-12.0 (-41.1;-2.5)^d	-1.1 (-6.8;5.3)	2015-2019	-5.3 (-8.8;17.9)
	–	–	–	2019-2021	-21.8 (-32.8;-10.1)^d
Roraima	2010-2021	5.2 (0.7;10.7)^d	5.2 (0.7;10.7)^d	2010-2013	16.0 (3.6;48.9)^d	1.3 (-1.5;4.5)
	–	–	–	2013-2016	-25.0 (-32.4;-13.0)^d
	–	–	–	2016-2021	11.8 (4.0;33.3)^d
Pará	2010-2012	-10.3 (-16.2;0.3)	-3.6 (-5.4;-1.9)^d	2010-2019	3.3 (1.7;6.4)^d	-1.8 (-3.8;0.7)
	2012-2019	5.4 (4.0;11.3)^d		2019-2021	-22.0 (-31.5;-6.8)^d	-1.8 (-3.8;0.7)
	2019-2021	-24.3 (-32.7;-13.3)^d		–	–	–
Amapá	2010-2021	7.9 (5.1;11.5)^d	7.9 (5.1;11.5)^d	2010-2021	1.5 (-3.6;7.4)	1.5 (-3.6;7.4)
Tocantins	2010-2021	5.5 (-1.0;13.5)	5.5 (-1.0;13.5)	2010-2021	2.6 (-3.9;10.7)	2.6 (-3.9;10.7)
Northeast	2010-2019	1.6 (0.2;3.9)^d	-2.5 (-4.5;-0.9)^d	2010-2019	0.8 (-0.2;2.4)	-2.3 (-3.6;-1.2)^d
Northeast	2019-2021	-19.1 (-28.0;-8.2)^d	-2.5 (-4.5;-0.9)^d	2019-2021	-15.3 (-21.8;-7.6)^d	-2.3 (-3.6;-1.2)^d
Maranhão	2010-2019	2.2 (0.8;5.0)^d	-1.7 (-3.6;0.4)	2010-2015	0.1 (-4.4;2.4)	-0.2 (-1.3;0.9)
	2019-2021	-17.2 (-27.2;-3.8)^d	-1.7 (-3.6;0.4)	2015-2019	9.9 (6.9;15.1)^d
	–	–	–	2019-2021	-18.2 (-23.5;-10.8)^d
Piauí	2010-2019	2.4 (-1.3;10.2)	-8.1 (-15.4;-2.3)^d	2010-2021	-0.6 (-3.1;1.7)	-0.6 (-3.1;1.7)
Piauí	2019-2021	-43.6 (-65.4;-10.7)^d	-8.1 (-15.4;-2.3)^d	–	–	–
Ceará	2010-2019	4.0 (1.4;12.9)^d	-1.4 (-4.3;2.6)	2010-2019	2.1 (-0.3;17.9)	-0.6 (-2.7;3.1)
Ceará	2019-2021	-22.2 (-35.0;-2.9)^d	-1.4 (-4.3;2.6)	2019-2021	-11.7 (-23.3;0.8)	-0.6 (-2.7;3.1)
Rio Grande do Norte	2010-2019	3.1 (0.4;18.2)^d	-3.1 (-7.3;2.6)	2010-2021	0.7 (-2.8;4.9)	0.7 (-2.8;4.9)
Rio Grande do Norte	2019-2021	-26.4 (-43.9;-2.7)^d	-3.1 (-7.3;2.6)	–	–	–
Paraíba	2010-2019	1.7 (-0.4;10.5)	-2.7 (-5.4;0.8)	2010-2021	-0.6 (-2.4;1.3)	-0.6 (-2.4;1.3)
Paraíba	2019-2021	-20.2 (-33.1;-2.9)^d	-2.7 (-5.4;0.8)	–	–	–
Pernambuco	2010-2012	9.1 (3.0;16.9)^d	-2.0 (-3.2;-0.8)^d	2010-2018	0.9 (-0.5;3.1)	-3.6 (-5.6;-2.4)^d
	2012-2019	-1.8 (-3.1;-0.5)^d		2018-2021	-14.6 (-28.1;-9.0)^d	-3.6 (-5.6;-2.4)^d
	2019-2021	-12.6 (-18.8;-6.9)^d		–	–	–
Alagoas	2010-2019	6.2 (3.5;12.3)^d	-1.7 (-5.7;2.3)	2010-2019	2.5 (-0.5;32.3)	-2.3 (-6.2;4.3)
Alagoas	2019-2021	-30.7 (-46.4;-9.9)^d	-1.7 (-5.7;2.3)	2019-2021	-21.4 (-39.5;-0.8)^d	-2.3 (-6.2;4.3)
Sergipe	2010-2021	4.2 (1.0;8.0)^d	4.2 (1.0;8.0)^d	2010-2016	-1.1 (-12.8;2.4)	-0.5 (-3.8;1.9)
	–	–	–	2016-2019	20.1 (9.2;29.9)^d
	–	–	–	2019-2021	-23.6 (-37.4;-6.8)
Bahia	2010-2012	-3.8 (-5.4;-1.5)^d	-4.5 (-5.0;-4.1)^d	2010-2019	-2.1 (-2.6;-1.2)^d	-3.8 (-4.5;-3.1)^d
	2012-2019	-0.6 (-1.0;0.7)		2019-2021	-11.2 (-15.1;-5.9)^d	-3.8 (-4.5;-3.1)^d
	2019-2021	-17.6 (-20.3;-15.6)^d		–	–	–
Southeast	2010-2019	0.0 (-0.8;1.1)	-3.0 (-4.0;-2.1)^d	2010-2019	-2.9 (-3.6;-1.8)^d	-6.0 (-7.2;-5.1)^d
Southeast	2019-2021	-15.3 (-20.6;-8.3)^d	-3.0 (-4.0;-2.1)^d	2019-2021	-18.7 (-24.7;-10.8)^d	-6.0 (-7.2;-5.1)^d
Minas Gerais	2010-2019	-0.4 (-3.1;9.8)	-4.5 (-7.6;-0.9)^d	2010-2019	-2.3 (-9.3;26.2)	-6.8 (-11.5;-0.6)^d
Minas Gerais	2019-2021	-20.9 (-34.4;-3.5)^d	-4.5 (-7.6;-0.9)^d	2019-2021	-24.4 (-45.5;-1.0)^d	-6.8 (-11.5;-0.6)^d
Espírito Santo	2010-2012	21.8 (5.9;38.4)^d	4.5 (2.4;6.7)^d	2010-2017	-4.4 (-7.3;-2.3)^d	0.6 (-0.7;1.9)
	2012-2018	-6.2 (-13.4;-4.1)^d		2017-2021	10.1 (5.0;20.1)^d	0.6 (-0.7;1.9)
	2018-2021	17.2 (6.7;36.2)^d		–	–	–
Rio de Janeiro	2010-2019	-0.4 (-1.1;0.8)	-2.9 (-4.0;-2.1)^d	2010-2019	-1.8 (-2.8;-0.3)^d	-5.6 (-7.0;-4.3)^d
Rio de Janeiro	2019-2021	-13.6 (-19.3;-6.6)^d	-2.9 (-4.0;-2.1)^d	2019-2021	-20.8 (-28.1;-10.6)^d	-5.6 (-7.0;-4.3)^d
São Paulo	2010-2016	-0.8 (-2.5;-0.2)^d	-3.4 (-4.0;-2.8)^d	2010-2019	-3.5 (-4.0;-2.8)^d	-6.6 (-7.3;-5.9)^d
	2016-2019	3.9 (1.6;5.6)^d		2019-2021	-19.3 (-23.2;-12.9)^d	-6.6 (-7.3;-5.9)^d
	2019-2021	-19.8 (-22.9;-16.5)^d		–	–	–
South	2010-2012	0.0 (-3.1;2.5)	-6.9 (-7.5;-6.4)^d	2010-2013	2.2 (-0.5;9.1)	-5.6 (-6.6;-4.8)^d
	2012-2019	-6.0 (-6.8;-5.4)^d		2013-2019	-5.0 (-6.1;-3.7)^d
	2019-2021	-16.2 (-18.9;-12.1)^d		2019-2021	-18.0 (-22.6;-12.5)^d
Paraná	2010-2013	3.9 (-2.3;18.7)	-3.4 (-5.4;-1.7)^d	2010-2012	-7.9 (-10.4;-5.0)^d	-5.8 (-6.3;-5.4)^d
	2013-2021	-5.9 (-11.4;-4.7)^d	-3.4 (-5.4;-1.7)^d	2012-2015	0.6 (-1.8;2.2)
	–	–	–	2015-2021	-8.2 (-9.5;-7.5)^d
Santa Catarina	2010-2019	-6.5 (-7.7;-3.4)^d	-9.7 (-12.0;-7.7)^d	2010-2015	-2.6 (-3.6;-0.4)^d	-9.4 (-10.3;-8.7)^d
	2019-2021	-23.0 (-33.7;-10.0)^d	-9.7 (-12.0;-7.7)^d	2015-2019	-7.4 (-9.5;-5.3)^d
	–	–	–	2019-2021	-27.5 (-31.9;-20.9)^d
Rio Grande do Sul	2010-2016	-3.4 (-4.9;-0.3)^d	-6.5 (-7.5;-5.6)^d	2010-2013	4.7 (1.3;12.0)^d	-4.3 (-5.3;-3.3)^d
	2016-2021	-10.0 (-15.2;-7.8)^d	-6.5 (-7.5;-5.6)^d	2013-2019	-4.3 (-5.6;-2.6)^d
	–	–	–	2019-2021	-16.3 (-21.2;-10.0)^d
Midwest	2010-2019	1.4 (0.1;9.2)^d	-1.4 (-3.5;1.4)	2010-2017	0.7 (-1.2;3.7)	-3.6 (-5.2;-2.2)^d
Midwest	2019-2021	-13.0 (-23.7;-1.0)^d	-1.4 (-3.5;1.4)	2017-2021	-10.5 (-18.3;-6.6)^d	-3.6 (-5.2;-2.2)^d
Mato Grosso do Sul	2010-2021	4.4 (-1.6;11.7)	4.4 (-1.6;11.7)	2010-2021	-1.6 (-5.6;2.7)	-1.6 (-5.6;2.7)
Mato Grosso	2010-2013	-11.4 (-23.5;-4.4)^d	-4.8 (-6.7;-3.4)^d	2010-2012	-11.6 (-21.6;4.0)	-5.1 (-7.0;-3.0)^d
	2013-2017	13.1 (7.2;22.1)^d		2012-2016	10.7 (1.9;22.0)^d
	2017-2021	-15.5 (-23.1;-10.5)^d		2016-2021	-13.7 (-20.4;-9.9)^d
Goiás	2010-2015	4.9 (-0.4;22.7)	-2.4 (-6.9;0.7)	2010-2017	0.4 (-3.2;33.3)	-5.0 (-9.7;0.5)
Goiás	2015-2021	-8.2 (-27.8;-4.4)^d	-2.4 (-6.9;0.7)	2017-2021	-13.7 (-40.2;-5.8)^d	-5.0 (-9.7;0.5)
Distrito Federal	2010-2021	-0.6 (-3.8;2.6)	-0.6 (-3.8;2.6)	2010-2012	25.9 (6.8;55.4)^d	-1.8 (-5.2;2.0)
	–	–	–	2012-2019	-2.5 (-6.1;1.0)
	–	–	–	2019-2021	-21.5 (-34.7;-7.8)^d
B razil	2010-2019	-0.3 (-1.0;0.7)	-3.6 (-4.7;-2.9)^d	2010-2019	-1.7 (-2.3;-1.0)^d	-5.1 (-5.8;-4.4)^d
B razil	2019-2021	-17.5 (-23.2;-10.7)^d	-3.6 (-4.7;-2.9)^d	2019-2021	-18.8 (-22.7;-12.3)^d	-5.1 (-5.8;-4.4)^d

[1] Correspondence: Lucas Vinícius de Lima | lvl.vinicius@gmail.com

Brasil

Brasil

Tendencia temporal de la incidencia de coinfección tuberculosis-VIH en Brasil, por macrorregión, Unidad Federativa, sexo y grupo de edad, 2010-2021

RESUMEN

Objetivo

Métodos

Resultados

Conclusión