Menéndez et al. [1616 Menéndez S, Falcón L, Simón DR, Landa N. Efficacy of ozonized sunflower oil in the treatment of tinea pedis. Mycoses. 2002;45(8):329-332. https://doi.org/10.1046/j.1439-0507.2002.00780.x https://doi.org/10.1046/j.1439-0507.2002...
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Randomized controlled phase III clinical trial. The effectiveness of ozonized oil in the treatment of Tinea pedis was evaluated. Ozonized oil was compared with 2% ketoconazole cream (Nizoral®, Janssen, São José dos Campos, SP, Brazil) in 200 people, with allocation of 100 patients in each group. Administration took place twice a day for 6 weeks. |
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All injuries regressed. From a clinical and mycological point of view, a success rate of 75 and 81% was achieved for ozonized oil and ketoconazole, respectively, with no statistically significant difference. None of the groups showed side effects. After 6 months of treatment, there was no recurrence in the ozone group. Ozonized oil proved to be an effective and low-cost medication. |
Menéndez et al. [1717 Menéndez S, Falcón L, Maqueira Y. Therapeutic efficacy of topical OLEOZON® in patients suffering from onychomycosis. Mycoses. 2011;54(5):272-277. https://doi.org/10.1111/j.1439-0507.2010.01898.x https://doi.org/10.1111/j.1439-0507.2010...
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Randomized phase III clinical trial for the treatment of onycosis. A total of 400 outpatients were randomly allocated to 2 groups: Experimental, treated with ozonized oil twice a day, and the control, treated twice a day with 2% cream ketoconazole (Nizoral®, Janssen, São José dos Campos, SP, Brazil), for 3 months. |
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In the group that used ozonized oil, 90.5% of the patients exhibited complete remission. In the control group, 13.5% achieved complete regression and 59% maintained the initial clinical aspect. One year later, the experimental and control group had 2.8% and 44.4% of relapses, respectively. Topical ozone therapy has shown superior efficacy in the treatment of onycosis. No side effects were observed. |
Campanati et al. [1818 Campanati A, De Blasio S, Giuliano A, et al. Topical ozonated oil versus hyaluronic gel for the treatment of partial- to full-thickness second-degree burns: A prospective, comparative, single-blind, non-randomised, controlled clinical trial. Burns. 2013;39(6):1178-1183.] |
A total of 30 patients with 2nd degree skin burns in the reepithelialization phase were included. The burn was subdivided into 2 symmetrical parts: 1 st treated with exclusive application of ozonized oil and the 2nd part, used hyaluronic acid gel, daily, for 12 weeks. All patients underwent clinical evaluation and videocapillaroscopy at the beginning of the study, 6 and 12 weeks later. |
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Regardless of the treatment used, all injuries showed improvement. Ozonized oil was as effective as hyaluronic acid in improving tension, itching, erythema and burning sensation signaled by patients. However, ozonized oil appears to be more effective than hyaluronic acid in reducing hyperpigmentation after injury (p<0.05). |
Solovăstru et al. [1919 Solovăstru LG, Stîncanu A, De Ascentii A, Capparé G, Mattana P, Vâţă D. Randomized, controlled study of innovative spray formulation containing ozonated oil and α-bisabolol in the topical treatment of chronic venous leg ulcers. Adv Skin Wound Care. 2015;28(9):406-409.] |
Randomized controlled study with 29 patients who had chronic venous ulcers for less than 2 years. Ozonized Oil 9.6% O3 and α-bisabolol (Azexin, Alfa Wassermann, Bologna, Italy) were administered in the Experimental group or cream of vitamin A and E, talc and zinc oxide, in the control group for 30 days. On days 0, 7, 14 and 30, ulcers were measured. The area of the wound and the speed of healing were calculated. |
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The group that received the formulation with ozonized oil and α-bisabolol showed complete healing of the ulcers (25% vs 0%). In addition, the ulcers in the Experimental group had a noticeable reduction in the wound, with 34%, 59% and 73% after 7, 14 and 30 days of ozone administration, respectively (p<0.05). |
Laureti et al. [2020 Laureti S, Aborajooh E, Mattioli B, Poggioli G. Treatment of minor dehiscence after endorectal advancement flap in perianal Crohn’s fistulas with ozonized oil NOVOX®. Tech Coloproctol. 2015;20(2):139-140. https://doi.org/10.1007/s10151-015-1404-4 https://doi.org/10.1007/s10151-015-1404-...
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A total of 26 patients with Crohn’s disease and residual fistula with minimal drainage were included in the study. Patients were treated with ozonized oil. This agent was administered daily for a period of 1 to 6 months |
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Residual healing of the fistula occurred in 65.4% (17/26) of the patients, with an average follow-up time of 23.81 (range, 2 to 42) months. |
Lu et al. [2121 Lu J, Guo M, Ligui H, Wu K, Xiang Y, Huang J, Gao L. Efficacy of combination of ozonated water with oil for treatment of tinea pedis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):147-151. Chinese. https://doi.org/10.11817/j.issn.1672-7347.2018.02.007 https://doi.org/10.11817/j.issn.1672-734...
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Randomized blind study with 60 patients with Tinea pedis, who were allocated to 2 groups. In the control group, Naftinfin Hydrochloride (Chongqing Hua Bang Pharmaceutical Ltd., China) and ketoconazole cream (Chongqing Hua Bang Pharmaceutical Ltd., China) were applied once a day. The ozone group was treated with an ozonized water bath and subsequent topical application of ozonized oil, once a day. The treatments took place for 4 weeks. At the end of the 1st, 2nd and 4th week, clinical and laboratory information was collected. |
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Within 4 weeks of therapy, 6 patients in the control group were positive by mycological examination, while 1 patient using ozone was positive, with no statistical difference between the groups (p>0.05). Changes in signs and symptoms at the end of the 1st, 2nd and 4th week were noted and did not show any significant difference between the groups, in the 3 different moments (p>0.05). No observations regarding side effects were reported. |
Quin et al. [2222 Qin G, Huang J, Pan Y, Xiang Y, Ou C, Huang J, et al. Topical ozone application: An innovative therapy for infantile atopic dermatitis. Med Sci. 2018;43(2):163-167. https://doi.org/10.11817/j.issn.1672-7347.2018.02.010 https://doi.org/10.11817/j.issn.1672-734...
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Randomized clinical study with 60 children with atopic dermatitis, who were allocated to the experimental group (n=30) and the control group (n=30). Hydrotherapy was performed 3-5 times a week and ozonized oil was applied twice a day. In the control group, washing was performed with warm running water and application of base oil (Nanhaizhi Medical Technoly Co., Ltd) and moisturizer, if necessary. The treatment lasted 2 weeks. |
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Inflammation in the skin reduced and erosions healed after 3-5 days of topical ozone application. The effective rates were 80% in the Experimental group and 20% in the control group in the respective treatments. |