Kuhn et al. [44 Kuhn A, Porto FA, Miraglia P, Brunetto AL. Low-level infrared laser therapy in chemotherapy induced oral mucositis: a randomized placebo controlled trial in children. J Pediatr Hematol Oncol. 2009; 31(1): 33-37.10.1097/MPH.0b013e318192cb8e] |
Randomized clinical trial |
18 |
NCI |
No rate |
Greater than or equal to 2 |
830 |
100 |
4 |
Yes |
Laser therapy, in addition to oral hygiene, may shorten the duration of chemotherapy-induced OM. |
Cauwels and Martens [1717 Cauwels R, Martens L. Low level laser therapy in oral mucositis: a pilot study. Eur Arch Paediatr Dent. 2011;12(2): 118-123. https://doi.org/10.1007/s10103-019-02722-7 https://doi.org/10.1007/s10103-019-02722...
] |
Pilot study |
16 |
WHO |
EVA and FACE |
1,2,3 and 4. |
830 |
150 |
Degree 1 - 2 Degree 2 - 4 Degree 3 - 6 Degree 4 - 8 |
Yes |
Reduction in the severity and duration of mucositis, in addition to pain relief. |
Amadori et al. [1111 Amadori F, Bardellini E, Conti G, Pedrini N, Schumacher RF, Majorana A. Low-level laser therapy for treatment of chemotherapy-induced oral mucositis in child hood: a randomized double-blind controlled study. Lasers Med Sci. 2016;31(6):1231-1236.https://doi.org/10.1007/s10103-016-1975-y https://doi.org/10.1007/s10103-016-1975-...
] |
Clinical trial |
85 |
WHO |
EVE |
Greater than or equal to 2 |
830 |
150 |
4.5 |
Yes |
No significant result in reducing the degree of mucositis, but pain relief. |
Ribeiro da Silva et al. [1818 Ribeiro da Silva VC, Silveira FMM, Monteiro MGB, Cruz MMD, Júnior ADFC, Godoy GP. Photodynamic therapy for treatment of oral mucositis: pilot study with pediatric patients chemotherapy. Photodiagnosis Photodyn Ther. 2018;21:115-120. https://doi.org/10.1016/j.pdpdt.2017.11.010 https://doi.org/10.1016/j.pdpdt.2017.11....
] |
Pilot study |
29 |
WHO |
CHI-MES |
Greater than 1 |
660 |
100 |
35 |
Yes |
Pain reduction and wound healing. |
Gobbo et al. [1212 Gobbo M, Verzegnassi F, Ronfani L, Zanon D, Melchionda F, Bagattoni S, et al. Multicenter randomized, double-blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. Pediatr Blood Cancer. 2018;65(8):27098. https://doi.org/10.1002/pbc.27098 https://doi.org/10.1002/pbc.27098...
] |
Randomized clinical trial |
75 |
WHO |
NRS 0-10 |
3 and 4 |
660 to 970 |
320 |
36.8 |
No |
Safe, viable and effective treatment for children, as it accelerates mucosal recovery and reduces pain. |
Tomaževič et al. [1313 Tomaževič T, Potočnik U, Cizerl D, Jazbec J. Optimization of Photobiomodulation Protocol for Chemotherapy-Induced Mucositis in Pediatric Patients. Photobiomodul Photomed Laser Surg. 2020;38(8):466-471. https://doi.org/10.1089/photob.2019.4794 https://doi.org/10.1089/photob.2019.4794...
] |
Clinical trial |
42 |
WHO |
No rate |
Degree 3 and 4 |
810 |
A-250 B-500 C-250 |
(A) 3- 8.8 (B) 4- 15.5 (C) 3- 4.4 4- 7.75 |
No report |
LLLT is an acceptable means of treating chemotherapy-induced MO in pediatric patients. |
Guimaraes et al. [1414 Guimaraes DM, Ota TNM, Da Silva DAC, Almeida FLS, Schalch TD, Deana AM, et al. Low-level laser or LED photobiomodulation on oral mucositis in pediatric patients under high doses of methotrexate: prospective, randomized, controlled trial. Support Care Cancer. 2021;29(11):6441-6447. https://doi.org/10.1007/s00520-021-06206-9 https://doi.org/10.1007/s00520-021-06206...
] |
Clinical trial |
40 |
WHO |
EVE |
- |
660 |
100 |
3.6 |
No report |
Findings suggest that LLLT has therapeutic effects on OM. |
Mohamed et al. [1515 Mohamed NH, Kamel AM, Edress MF, Mahmoud ASS, Gaafar AIAEH. Low level laser therapy versus benzydamin in prevention and treatment of oral mucositis induced by anticancer treatments (clinical and biochemical study). Braz Dental Sci. 2022;25(4): e3406. https://doi.org/10.4322/bds.2022.e3406 https://doi.org/10.4322/bds.2022.e3406...
] |
Clinical trial |
30 |
NIC |
EVE |
Greater than or equal to 2 |
870 |
60 |
Average from 5 to 150 |
Yes |
LLLT decreases the prevalence, discomfort, and severity of OM. |
Reyad et al. [1616 Reyad FA, Elsayed NM, EL Chazli Y. Photobiomodulation for chemotherapy-induced oral mucositis in leukemic children: A randomized controlled clinical trial. Oral Dis. 2023;29(5):2239-2247. https://doi.org/10.1111/odi.14217 https://doi.org/10.1111/odi.14217...
]. |
Clinical trial |
44 |
WHO |
EVE |
1,2,3,4 |
980 |
1.5 |
4.5 |
Yes |
The use of LLLT, along with conventional treatment, was effective in reducing pain and healing OM lesions in children undergoing chemotherapy. It was also safe and applicable to children. |