1 |
51 years Male |
08/2004 IgG κ, SPEP: 1.2g/dL, ISS: stage2 DS IIIB |
-
1st: Induction: high dose Dexa 3 cycles
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ASCT: melphalan 200 mg/m2 -01/2005
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Maintenance: interferon γ+ Dexamethasone until 07/2007
|
CR |
01/2005 Pneumonia/06/2005 H. Zoster, Death 8/2019 - aortic aneurysm |
Echocardiogram -hypokinesia VE, Left VE hypertrophy, ECG -Anterosuperior Division Block (Cardiac) |
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06/01/2004 N H0X0
-
03/29/2005 N H0X0
-
07/03/2007 N H0X0
-
02/26/2008 N H0X0
-
12/10/2008 N H0X0
-
05/01/2010 N H0X0
-
12/07/2010 N H0X0
|
-
U/N
-
U/N
-
U/N
-
U/N
-
U/N
-
U/N
-
U/N
|
78 months* |
2 |
55 years Female |
09/2004 Subtype, SPEP, ISS: unknown DS IIIB |
-
1st Induction: Melphalan + dexamethasone: 09/2004 - 04/2005
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2nd Induction: VAD 4 cycles: 04/05 – 09/05
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ASCT: Busulfan 12 mg/kg + melphalan 100 mg/m2 – 05/2006
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Thalidomide: 07/2006 – 07/2010
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Radiotherapy: 01/2010 – 04/2010 due to myeloma recurrence,
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09/2010: Melphalan +Prednisone + Thalidomide
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Radiotherapy re-started in 12/2010
|
CR |
Lost to follow-up on 04/2011 |
ECG changes in ventricular repolarization, Chest XR – normal, Holter 09/2008 isolated Supra-ventricular isolated arrhythmia, Echocardiogram – Diastolic dysfunction** (Significant non-specific ECG changes + Diastolic dysfunction)** |
-
02/21/2006 PH0X0
-
07/25/2006 PH+X+
-
10/09/2007P/H+X0
-
09/30/2008 PH+X+
-
10/17/2008 PH+X+
-
01/06/2009PH+X+
-
03/03/2009 PH+X+
-
03/12/2009 PH+X0
-
03/25/2009 NH+X+
-
04/23/2009 NH0X0
-
08/25/2009 PH+X0
-
11/17/2009 NH+X0
-
04/23/2010 P
-
07/06/2010 P
-
01/18/2011 PH+X+
|
-
3.2/N
-
5.4//N
-
6.6/N
-
56.4/N
-
127.0/N
-
124.8/N
-
256.0/N
-
120.8/N
-
U/N
-
U/N
-
0.36/N
-
U//N
-
0.07NA
-
10.9/NA
-
0.95/N
|
59 months* 28 months 28.5 months 31 months 33.5 months 03/07/2009 7 mg/kg/d –BNZ Exanthema 18th day |
3 |
55 years Female |
07/2004 IgG λ, SPEP: 0.73 g/dL, ISS: stage 3 DS IIIA |
-
1st:Induction: high dose Dexa 1 cycle + VAD 3 cycles 11/2004 – 02/2005
-
Maintenance: thalidomide until 01/2006
-
ASCT: Busulfan 12 mg/kg + melphalan 100 mg/m2- 01/2006
|
CR |
Lost to follow-up on 06/ 2006 |
No cardiac abnormalities (Noncardiac) |
-
08/30/2005 NH0X0
-
01/12/2006 NH0X0
-
02/01/2006 NH0X0
-
03/15/2006 N
-
04/07/2006 N
|
|
7 months* |
4 |
37 years Female |
Date: 11/2010 IgG κ, SPEP:2.5g/dL ISS: stage 2, DS IIIA |
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1st: CTD 9 cycles 12/2010 -08/2011
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2nd: Induction: CTD 4 × cycles 05/2015- 10/2015
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ASCT: melphalan 200mg/m2 – 04/2016
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3rd: CTD 6 cycles 01/2019 – 06/2019
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4th: CD 8 cycles 01/2020- 08 2020
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5th: CVAD 5 cycles 09//2020- 02/2021
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6th: VD 7 cycles 05/2021-11/2021
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7th: MD 4 cycles 05/2022 -08//2022
|
-
PR
-
VGPR
-
Stable
-
Stable
-
Stable
-
PR
-
Progression
|
Alive March 2023 |
Normal ECG and Chest XR, Contrast-enhanced esophageal XR - grade 1 dysmotility (Digestive form) |
-
07/22/2014 NH0
-
01/05/2015 NH0
-
09/28/2015 NH0
-
04/25/2016 NH0
-
01/24/2017 N
-
06/22/2018 N
-
03/28/2019 N
-
10/19/2020 N
-
11/09/2021 N
-
03/08/2022N
|
-
U/N
-
U/N
-
U/N
-
U/N
-
NA/N
-
NA/N
-
NA/N
-
NA/N
-
NA/N
-
NA/N
|
88 months* BNZ 08/2006 for 44 days due to Gastric intolerance and peripheral neuropathy |
5 |
55 y Male |
07/2013: IgG κ, SPEP: 2.04 /dL, ISS: stage 1, DS IIIA |
-
1st: Induction: CTD 8 cycles 06/2014- 01/2015
-
2nd :Induction: CTD 10 cycles 02/2016 –11/2016
-
ASCT: melphalan 200 mg/m2 -3/2017
|
|
Lost to follow-up on 06/2017 |
ECG- normal, Echo-cardiogram – Diastolic dysfunction, left auricular enlargement (Diastolic dysfunction)** |
-
12/07/2015 N H0
-
03/28/2016 N H0
-
07/04/2016 N
-
12/12/2016 N
-
04/07/2017 N
|
|
52 months* |
6 |
58 years Male |
08/2015, IgG κ, SPEP: 3.6g/dL, ISS: stage 3, DS IIIA |
-
1st Induction: CTD 9 cycles 09/2015-05/2016
-
ASCT: melphalan 200 g/m
2
08/2016
-
2nd Induction: CD 5 cycles01/2009-05/2009 5 cycles 01/2019-05/2019
-
ASCT: melphalan 200g/m
2
07/2019
-
3rd:CD 6 cycles 08/2020 -06/2021
-
4th VCD 8 cycles 09/2021-03/2022
|
|
Alive February 2023 |
ECG – normal 2016 and possible LV overload – 2019, 2015/2016 –Normal Echocardiogram, XR - EED (Significant non-specific ECG changes) |
-
04/19/2016 N
-
04/25/2016 N
-
08/19/2019 N
-
09/04/2019 N
|
|
42 months* |
7 |
59 years Male |
11/2015 IgG κ, SPEP: 2.5g/dL, ISS: stage 2, DS IIIA |
-
1st: CTD 8 cycles 11/18/2015-07/17/2016
-
ASCT: 01/12/2017
-
2nd: CTD 9 cycles 03/25/2020-12/09/2020
-
3rd: VTD 8 cycles 11/09/2021 – 06/30/2022
-
ASCT: 01/12/2017
|
|
Alive February 2023 |
ECG right branch block, Echo: diffuse hypokinesia, Diastolic dysfunction, discrete systolic dysfunction LVE EF 52% (Cardiac) |
-
06/06/2016 N
-
07/04/2016 N
-
01/27/2017 N
-
08/08/2017 N
-
02/07/2020 N
-
11/16/2021 N
|
-
U/NA
-
U//N
-
NA/N
-
NA/N
-
NA/N
-
NA/N
|
65 months* |