Our case |
Male 29 |
Persistent hiccups Two-day history |
Chest CT scan with ground-glass opacities and small sparse areas of atelectasis Positive RT-PCR for SARS-CoV-2 |
Chlorpromazine |
Symptoms improved after 10 h |
Dorgalaleh et al.99. Dorgalaleh A, Dabbagh A, Tabibian S, Bahraini M, Rafieemehr H. Persistent hiccups in a patient with mild congenital factor V deficiency and COVID-19; clinical and laboratory finding of a rare bleeding disorder. Int J Lab Hematol. 2021;43:e87-8. |
Male 52 |
Persistent hiccups |
Chest CT scan with ground-glass in the left lower lobe Positive RT-PCR for SARS-CoV-2 |
Metoclopramide Chlorpromazine |
Symptoms improved after 5 days |
Ikitimur et al.1010. Ikitimur H, Borku Uysal B, Ikitimur B, Umihanic S, Smajic J, Jahic R, et al. Two cases of persistent hiccups complicating COVID-19. Am J Trop Med Hyg. 2021;104:1713-5. |
Male 60 |
Persistent hiccups Three-day history |
Chest CT scan with ground-glass in the left lower lobe Positive RT-PCR for SARS-CoV-2 |
Chlorpromazine |
Symptoms improved after 12 h |
Male 68 |
Persistent hiccups |
Chest CT scan with ground-glass in the left lower lobe Positive RT-PCR for SARS-CoV-2 |
Chlorpromazine |
Symptoms improved after 3 days |
Prince and Serge55. Prince G, Sergel M. Persistent hiccups as an atypical presenting complaint of COVID-19. Am J Emerg Med. 2020;38:1546.e5-6. |
Male 62 |
Persistent hiccups Four-day history |
Chest CT scan with ground-glass opacities Positive RT-PCR for SARS-CoV-2 |
None |
Symptoms improved |
Bakheet et al.1111. Bakheet N, Fouad R, Kassem AM, Hussin W, El-Shazly M. Persistent hiccup: a rare presentation of COVID-19. Respir Investig. 2021;59:263-5. |
Male 48 |
Persistent hiccups Seven-day history |
Chest CT scan with ground-glass opacities Positive RT-PCR for SARS-CoV-2 |
Baclofen |
Symptoms improved |
Alvarez-Cisneros et al.1212. Alvarez-Cisneros T, Lara-Reyes A, Sansón-Tinoco S. Hiccups and psychosis: two atypical presentations of COVID-19. Int J Emerg Med. 2021;14:8. |
Male 48 |
Persistent hiccups Four-day history |
Chest CT scan with ground-glass opacities Positive RT-PCR for SARS-CoV-2 |
Metoclopramide, omeprazol, ondanseteon and oral frappe megaldrate/ dimeticone |
No improvement Patient refused hospital admission and was lost to follow-up |
Totomoch-Serra et al.1313. Totomoch-Serra A, Ibarra-Miramon CB, Manterola C. Persistent hiccups as main COVID-19 symptom. Am J Med Sci. 2021;361:799-800. |
Male 60 |
Persistent hiccups |
Chest X-ray showing lung parenchyma with decreased radiolucency of images with poorly defined irregular edges |
Clonazepam Haloperidol |
Symptoms improved after 3 days |
Sangamesh et al.1414. Sangamesh S, Gosavi S, Shastry S, Johny SM. Hiccups and hyponatremia: unusual co-presentation in COVID-19. J Family Med Prim Care. 2021;10:1040-3. |
Male 72 |
Persistent hiccups Five-day history |
Chest X-ray with bilateral lower lobe infiltrates Positive RT-PCR for SARS-CoV-2 |
Baclofen |
Symptoms improved after 2 days |
Atiyat et al.1515. Atiyat R, Veeraballi S, Al-Atiyat N, Chan KH, Slim J. A rare case report of persistent hiccups as an atypical presentation of COVID-19. Cureus. 2021;13:e13625. |
Male 61 |
Persistent hiccups Two-day history |
Chest X-ray with bilateral middle lung opacities Positive RT-PCR for SARS-CoV-2 |
Metoclopramide |
- |
Chiquete et al.1616. Chiquete E, Toapanta-Yanchapaxi L, Aceves-Buendía JJ, Ruiz-Ruiz E, Rodríguez-Perea E, Durán-Coyote S, et al. Levosulpiride relieved persistent hiccups in a patient With COVID-19 and vascular cognitive impairment. Clin Neuropharmacol. 2021 In Press. |
Male 62 |
Persistent hiccups Five-day history |
Chest CT scan with viral pneumonia Positive RT-PCR for SARS-CoV-2 |
Levomepromazine Levosulpiride |
Symptoms improved after 3 days |