Ferrando, et al. Br J Anaesth. 2020.3030. Ferrando C, Aldecoa C, Unzueta C, Belda FJ, Librero J, Tusman G, et al. Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial. Br J Anaesth. 2020;124(1):110-20. doi: 10.1016/j.bja.2019.10.009 https://doi.org/10.1016/j.bja.2019.10.00...
|
Abdominal |
IO‡ (OTI§) and PO|| (rebreathing face mask for 3 h) n=371 |
IO‡ (OTI§) and PO|| (Venturi mask for 3 h) n=369 |
IG¶=8.9% CG**=9.4% (p=0.9) |
Mayank, et al. J Gastrointest Surg. 2019.3434. Mayank M, Mohsina S, Sureshkumar S, Kundra P, Kate V. Effect of Perioperative High Oxygen Concentration on Postoperative SSI in Elective Colorectal Surgery-A Randomized Controlled Trial. J Gastrointest Surg. 2019;23(1):145-52. doi: 10.1007/s11605-018-3996-2 https://doi.org/10.1007/s11605-018-3996-...
|
Colorectal |
IO‡ (OTI§) and PO|| (rebreathing face mask for 6 h) n=47 |
IO‡ (OTI§) and PO|| (Venturi mask for 6 h) n=47 |
IG¶=55.3% CG**=0.4% (p=0.215) |
Kurz, et al. Br J Anaesth. 2015.3333. Kurz A, Fleischmann E, Sessler DI, Buggy DJ, Apfel C, Akça O, Factorial Trial Investigators. Effects of supplemental oxygen and dexamethasone on surgical site infection: a factorial randomized trial. Br J Anaesth. 2015;115(3):434-43. doi: 10.1093/bja/aev062 https://doi.org/10.1093/bja/aev062...
|
Colorectal |
IO‡ (OTI§) and PO|| (rebreathing face mask for 1 h) n=285 |
IO‡ (OTI§) and PO|| (Venturi mask for 1 h) n=270 |
IG¶=15.6% CG**=15.8% (p=0.201)††
|
Wadhwa, et al. Anest Analg. 2014.3838. Wadhwa AKB. Supplemental Postoperative Oxygen Does Not Reduce Surgical Site Infection and Major Healing-Related Complications from Bariatric Surgery in Morbidly Obese Patients: A Randomized, Blinded Trial. Anesth Analg. 2014;119(2):357-65. doi: 10.1213/ANE.0000000000000318 https://doi.org/10.1213/ANE.000000000000...
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Bariatric |
IO‡ (OTI§) and PO|| (10 L/min by rebreathing face mask or 15 L/min via nasal cannula, for 12 h to 16 h) n=202 |
IO‡ (OTI§) and PO|| (nasal cannula 2 L/min) n=198 |
IG¶=7.9% CG**=9.1% (p=0.80)††
|
Thibon, et al. Anesthesiology. 2012.3737. Thibon P, Borgey F, Boutreux S, Hanouz JL, Le Coutour X, Parienti JJ. Effect of perioperative oxygen supplementation on 30-day surgical site infection rate in abdominal, gynecologic, and breast surgery: the ISO2 randomized controlled trial. Anesthesiology. 2012;117(3):504-11. doi: 10.1097/ALN.0b013e3182632341 https://doi.org/10.1097/ALN.0b013e318263...
|
Abdominal, gynecological and breast |
IO‡ (OTI§) and PO|| (nebulization mask, it does not describe the postoperative time, it suggests that it was only during the stay in the post-anesthetic recovery room) n=226 |
n=208 |
IG¶=6.6% CG**=7.2% (p=0.81) |
Staehr, et al. Anesthesiol. 2011.3636. Staehr AK, Meyhoff CS, Rasmussen LS. PROXI Trial Group. Inspiratory Oxygen Fraction and Postoperative Complications in Obese Patients A Subgroup Analysis of the PROXI Trial. Anesthesiology. 2011;114(6):1313-9. doi: 10.1097/ALN.0b013e31821bdb82 https://doi.org/10.1097/ALN.0b013e31821b...
|
Abdominal, in obese individuals |
IO‡ (OTI§) and PO|| (nebulization mask with variable supply, not reported, for 2 h) n=102 |
n=111 |
IG¶=26% CG**=31% (p=0.4) |
Scifres, et al. Am J Obstet Gynecol. 2011.4343. Hopf HW, Holm J. Hyperoxia and infection. Best Pract Res Clin Anaesthesiol. 2008;22(3):553-69. doi: 10.1016/j.bpa.2008.06.001 https://doi.org/10.1016/j.bpa.2008.06.00...
|
C-section |
n=288 Intraoperative and postoperative intervention (nasal cannula 2 L/min X 10 L/min by face mask, for 2 h) |
n=297 |
IG¶=12.2% CG**=8.8% (p=0.28) |
Meyhoff, et al. JAMA. 2009.3535. Meyhoff CS, Wetterslev J, Jorgensen LN, Henneberg SW, Høgdall C, Lundvall L, et al. Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial. JAMA. 2009;302(14):1543-50. doi: 10.1001/jama.2009.1452 https://doi.org/10.1001/jama.2009.1452...
|
Abdominal |
IO‡ (OTI§) and PO|| (nebulization mask with variable supply, not reported, for 2 h) n=685 |
n=701 |
IG¶=19.1% GC**=20.1% (p=0.81) |
Belda, et al. JAMA. 2005.2828. Belda FJ, Aguilera L, García de la Asunción J, Alberti J, Vicente R, Ferrándiz L. Supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial. JAMA. 2005;26(294):2035-42. doi: 10.1001/jama.294.16.2035 https://doi.org/10.1001/jama.294.16.2035...
|
Colorectal |
IO‡ (OTI§) and PO|| (nebulization mask with variable supply, not reported, for 6 h) n=148 |
n=143 |
IG¶=14.9% CG**=24.4% (p=0.13) |
Mayzler, et al. Minerva Anestesiol. 2005.4141. Mayzler O, Weksler N, Domchik S, Klein M, Mizrahi S, Gurman GM. Does supplemental perioperative oxygen administration reduce the incidence of wound infection in elective colorectal surgery? Minerva Anestesiol. 2005;71(1-2):21-5. doi: 10.1186/s13054-014-0711-x https://doi.org/10.1186/s13054-014-0711-...
|
Colorectal |
IO‡ (OTI§) and PO|| (non-rebreathing face mask, for 2 h) n=19 |
n=19 |
IG¶=12.5% CG**=15.7% (p=0.53) |
Pryor, et al. JAMA. 2004.4242. Pryor KO, Fahey TJ 3rd, Lien CA, Goldstein PA. Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial. JAMA. 2004;291(1):79-87. doi: 10.1001/jama.291.1.79 https://doi.org/10.1001/jama.291.1.79...
|
Abdominal |
IO‡ (OTI§) and PO|| (non-rebreathing face mask 10 L/min for 2 h) n=80 |
IO† (OTI‡) and PO|| (nasal cannula 4 L/min for 2 h) n=80 |
IG¶=11.3% CG**=25% (p=0.13) |
Greif, et al. N Engl J Med. 2000.3232. Greif R, Akça O, Horn EP, Kurz A, Sessler DI. Outcomes Research Group. Supplemental perioperative oxygen to reduce the incidence of surgical-wound infection. N Engl J Med. 2000;342(3):161-7. doi: 10.1056/NEJM200001203420303 https://doi.org/10.1056/NEJM200001203420...
|
Colorectal |
IO‡ (OTI§) and PO|| (non-rebreathing face mask, for 2 h) n=250 |
n=250 |
IG¶=5.2% CG**=11.2% (p=0.01) |
Regional Anesthesia
|
Duggal, et al. Obstet Gynecol. 2013.2929. Duggal NPV. Perioperative oxygen supplementation and surgical site infection after cesarean delivery: a randomized trial. Obstet Gynecol. 2013;122(1):79-84. doi: 10.1097/AOG.0b013e318297ec6c https://doi.org/10.1097/AOG.0b013e318297...
|
C-section |
IO‡ and PO|| (nebulization mask 10 L/min, for 1 h) n=415 |
n=416 |
IG¶=5.5% CG**=5.8% (p=0.98) |
Williams, et al. Am J Perinatol. 2013.3939. Williams NL, Glover MM, Crisp C, Acton AL, Mckenna DS. Randomized Controlled Trial of the Effect of 30% versus 80% Fraction of Inspired Oxygen on Cesarean Delivery Surgical Site Infection. Am J Perinatol. 2013;30(9):781-6. doi: 10.1055/s-0032-1333405 https://doi.org/10.1055/s-0032-1333405...
|
C-section |
IO‡ and PO|| (nebulization mask with variable offer, not reported, for 2 h) n=77 |
n=83 |
IG¶=13% CG**=14.5% (p=0.82)††
|
Gardella, et al. Obstet Gynecol. 2008.3131. Gardella C, Goltra LB, Laschansky E, Drolette L, Magaret A, Chadwick HS, et al. High-concentration supplemental perioperative oxygen to reduce the incidence of postcesarean surgical site infection: a randomized controlled trial. Obstet Gynecol. 2008;112(3):545-52. doi: 10.1097/AOG.0b013e318182340c https://doi.org/10.1097/AOG.0b013e318182...
|
C-section |
IO‡ and PO|| (non-rebreathing mask, for 2 h) n=69 |
n=83 |
IG¶=14% CG**=25% (p=0.13)††
|