Santos (201018. Santos ICR, Frigeri HR, Réa RR, Almeida ACR, Souza EM, Pedrosa FO, et al. The glucokinase gene promoter polymorphism -30G>A (rs1799884) is associated with fasting glucose in healthy pregnant women but not with gestational diabetes. Clin Chim Acta. 2010;411(11-12):892-3. https://doi.org/10.1016/j.cca.2010.03.011 https://doi.org/10.1016/j.cca.2010.03.01...
) [1717. Santos ICR. Estudo de variações dos genes do receptor para produtos de glicação avançada (RAGE), preprogrelina e glucoquinase no diabetes gestacional [dissertação]. Curitiba: Universidade Federal do Paraná; 2010. ] |
Women diagnosed with gestational diabetes and healthy pregnant women |
Curitiba, PR |
GCK |
rs1799884 |
A |
0.240/0.200 |
750 |
BDTD |
Santos et al. (201018. Santos ICR, Frigeri HR, Réa RR, Almeida ACR, Souza EM, Pedrosa FO, et al. The glucokinase gene promoter polymorphism -30G>A (rs1799884) is associated with fasting glucose in healthy pregnant women but not with gestational diabetes. Clin Chim Acta. 2010;411(11-12):892-3. https://doi.org/10.1016/j.cca.2010.03.011 https://doi.org/10.1016/j.cca.2010.03.01...
) [1818. Santos ICR, Frigeri HR, Réa RR, Almeida ACR, Souza EM, Pedrosa FO, et al. The glucokinase gene promoter polymorphism -30G>A (rs1799884) is associated with fasting glucose in healthy pregnant women but not with gestational diabetes. Clin Chim Acta. 2010;411(11-12):892-3. https://doi.org/10.1016/j.cca.2010.03.011 https://doi.org/10.1016/j.cca.2010.03.01...
] |
Unrelated Euro-Brazilian pregnant women |
Curitiba, PR |
GCK |
rs1799884 |
A |
0.240/0.200 |
750 |
PUBMED |
Frigeri et al. (201219. Frigeri HR, Santos ICR, Réa RR, Almeida ACR, Fadel-Picheth CMT, Pedrosa FO, et al. Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control. Genet Mol Res. 2012;11(2):1433-41. https://doi.org/10.4238/2012.May.18.2 https://doi.org/10.4238/2012.May.18.2...
) [1919. Frigeri HR, Santos ICR, Réa RR, Almeida ACR, Fadel-Picheth CMT, Pedrosa FO, et al. Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control. Genet Mol Res. 2012;11(2):1433-41. https://doi.org/10.4238/2012.May.18.2 https://doi.org/10.4238/2012.May.18.2...
] |
Women diagnosed with gestational diabetes and healthy pregnant women |
Curitiba, PR |
GCK |
c.43331A>G; rs2268574; rs2908274; rs13306388 |
G; C; T; A |
n/a |
200 |
PUBMED |
Frigeri et al. (201424. Frigeri HR, Martins LT, Auwerter NC, Santos-Weiss ICR, Pedrosa FO, Souza EM, et al. The polymorphism rs2268574 in Glucokinase gene is associated with gestational diabetes mellitus. Clin Biochem. 2014;47(6):499-500. https://doi.org/10.1016/j.clinbiochem.2014.01.024 https://doi.org/10.1016/j.clinbiochem.20...
) [2424. Frigeri HR, Martins LT, Auwerter NC, Santos-Weiss ICR, Pedrosa FO, Souza EM, et al. The polymorphism rs2268574 in Glucokinase gene is associated with gestational diabetes mellitus. Clin Biochem. 2014;47(6):499-500. https://doi.org/10.1016/j.clinbiochem.2014.01.024 https://doi.org/10.1016/j.clinbiochem.20...
] |
Euro-Brazilian women diagnosed with gestational diabetes and healthy pregnant women |
Curitiba, PR |
GCK |
rs2268574 |
T |
0.384/0.483 |
227 |
PUBMED |
Frigeri (201526. Frigeri HR. Variabilidade genética e sequenciamento de genes associados ao diabetes mellitus tipo 2 e à obesidade [tese]. Curitiba: Universidade Federal do Paraná; 2015. ) [2626. Frigeri HR. Variabilidade genética e sequenciamento de genes associados ao diabetes mellitus tipo 2 e à obesidade [tese]. Curitiba: Universidade Federal do Paraná; 2015. ] |
Biorepository samples |
Curitiba, PR |
GCK |
rs144723656; rs2268574; rs2268575 |
T; T; G |
0.014/0.008; 0.429/0.450; 0.220/0.223 |
227 |
BDTD |
Frigeri et al. (201629. Frigeri HR, Auwerter NC, Koczicki L, Martins LT, Souza EM, Alberton D, et al. Polymorphisms rs144723656, rs2268574, and rs2268575 of the glucokinase gene are not associated with obese women with type 2 diabetes mellitus. Clin Biochem . 2016;49(1-2):194-5. https://doi.org/10.1016/j.clinbiochem.2015.09.016 https://doi.org/10.1016/j.clinbiochem.20...
) [2929. Frigeri HR, Auwerter NC, Koczicki L, Martins LT, Souza EM, Alberton D, et al. Polymorphisms rs144723656, rs2268574, and rs2268575 of the glucokinase gene are not associated with obese women with type 2 diabetes mellitus. Clin Biochem . 2016;49(1-2):194-5. https://doi.org/10.1016/j.clinbiochem.2015.09.016 https://doi.org/10.1016/j.clinbiochem.20...
] |
Unrelated Euro-Brazilian women |
Curitiba, PR |
GCK |
rs144723656; rs2268574; rs2268575 |
T; T; G |
0.014/0.008; 0.429/0.450; 0.220/0.223 |
271 |
PUBMED |
Lepore (201628. Lepore CS. Estudo de alterações moleculares no gene da Glucoquinase (GCK) associado ao diagnóstico de diabetes do adulto de início no jovem (Maturity Onset Diabetes of the Young-MODY) em gestantes e neonatos [dissertação]. Ribeirão Preto: Universidade de São Paulo; 2016. ) [2828. Lepore CS. Estudo de alterações moleculares no gene da Glucoquinase (GCK) associado ao diagnóstico de diabetes do adulto de início no jovem (Maturity Onset Diabetes of the Young-MODY) em gestantes e neonatos [dissertação]. Ribeirão Preto: Universidade de São Paulo; 2016. ] |
Pregnant women diagnosed with diabetes mellitus and their newborns |
Ribeirão Preto, SP |
GCK |
rs35670475; rs2268574; rs144723656 |
T; T; T |
n/a |
201 |
BDTD |
Bride et al. (202163. Bride L, Naslavsky M, Lopes Yamamoto G, Scliar M, Pimassoni LH, Sossai Aguiar P, et al. TCF7L2 rs7903146 polymorphism association with diabetes and obesity in an elderly cohort from Brazil. PeerJ. 2021;9:e11349. https://doi.org/10.7717/peerj.11349 https://doi.org/10.7717/peerj.11349...
) [6363. Bride L, Naslavsky M, Lopes Yamamoto G, Scliar M, Pimassoni LH, Sossai Aguiar P, et al. TCF7L2 rs7903146 polymorphism association with diabetes and obesity in an elderly cohort from Brazil. PeerJ. 2021;9:e11349. https://doi.org/10.7717/peerj.11349 https://doi.org/10.7717/peerj.11349...
] |
Elderly volunteers from SABE health survey |
São Paulo, SP |
TCF7L2 |
rs7903146 |
T |
0.27-0.40 |
1023 |
PUBMED |
Cirelli et al. (202164. Cirelli T, Nepomuceno R, Goveia JM, Orrico SRP, Cirelli JA, Theodoro LH, et al. Association of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association-identified risk variants in a Southeastern Brazilian population. Clin Oral Invest. 2021;25(6):3873-92. https://doi.org/10.1007/s00784-020-03717-3 https://doi.org/10.1007/s00784-020-03717...
) [6464. Cirelli T, Nepomuceno R, Goveia JM, Orrico SRP, Cirelli JA, Theodoro LH, et al. Association of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association-identified risk variants in a Southeastern Brazilian population. Clin Oral Invest. 2021;25(6):3873-92. https://doi.org/10.1007/s00784-020-03717-3 https://doi.org/10.1007/s00784-020-03717...
] |
Individuals treated at the Periodontology Department, Universidade Estadual Paulista |
Araraquara, SP |
TCF7L2 |
rs7903146 |
T |
0.26 |
931 |
PUBMED |
Wunsch et al. (2019) [6161. Wunsch C, Dornelles TF, Girardi P, Arndt ME, Genro JP, Contini V. Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease. Endocr Regul. 2018;53(1):1-7. https://doi.org/10.2478/enr-2019-0001 https://doi.org/10.2478/enr-2019-0001...
] |
European patients that underwent coronary angiography |
Lajeado, RS |
TCF7L2 |
rs12255372; rs7903146 |
T; T |
0.31; 0.32 |
647 |
PUBMED |
Ferreira et al. (201860. Ferreira MC, Silva MER, Fukui RT, Arruda-Marques M C, Santos RF. TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity. Diabetol Metab Syndr . 2018;10:37. https://doi.org/10.1186/s13098-018-0338-1 https://doi.org/10.1186/s13098-018-0338-...
) [6060. Ferreira MC, Silva MER, Fukui RT, Arruda-Marques M C, Santos RF. TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity. Diabetol Metab Syndr . 2018;10:37. https://doi.org/10.1186/s13098-018-0338-1 https://doi.org/10.1186/s13098-018-0338-...
] |
Patients with T2D |
São Paulo, SP |
TCF7L2 |
rs7903146 |
T |
n/a |
162 |
PUBMED |
Anghebem-Oliveira et al. (201766. Anghebem-Oliveira MI, Webber S, Alberton D, Souza EM, Klassen G, Picheth G, et al. The GCKR gene polymorphism rs780094 is a risk factor for gestational diabetes in a Brazilian population. J Clin Lab Anal. 2017;31(2):e22035. https://doi.org/10.1002/jcla.22035 https://doi.org/10.1002/jcla.22035...
) [5858. Anghebem-Oliveira MI, Martins BR, Alberton D, Ramos EA S, Picheth G, Rego FG de M. Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population. Arch Endocrinol Metab . 2017;61(3):238-48. https://doi.org/10.1590/2359-3997000000258 https://doi.org/10.1590/2359-39970000002...
] |
Unrelated Euro-Brazilian pregnant women |
Curitiba, PR |
TCF7L2 |
rs7901695 |
C |
0.336; 0.390 |
252 |
PUBMED |
Anghebem-Oliveira (201555. Anghebem-Oliveira MI. Avaliação de biomarcadores e variantes genéticas no Diabetes Mellitus Tipo 1, Tipo 2 e gestacional [tese]. Curitiba: Universidade Federal do Paraná; 2015. ) [5555. Anghebem-Oliveira MI. Avaliação de biomarcadores e variantes genéticas no Diabetes Mellitus Tipo 1, Tipo 2 e gestacional [tese]. Curitiba: Universidade Federal do Paraná; 2015. ] |
Patients with T1D, T2D or GD |
Curitiba, PR |
TCF7L2 |
rs7901695 |
T |
0.664; 0.610 |
967 |
BDTD |
de Melo et al. (201556. Melo SF, Frigeri HR, dos Santos-Weiss ICR, Réa RR, de Souza EM, Alberton D, et al. Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes. Clin Biochem . 2015;48(16-17 ):1064-7. https://doi.org/10.1016/j.clinbiochem.2015.06.013 https://doi.org/10.1016/j.clinbiochem.20...
) [5656. Melo SF, Frigeri HR, dos Santos-Weiss ICR, Réa RR, de Souza EM, Alberton D, et al. Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes. Clin Biochem . 2015;48(16-17 ):1064-7. https://doi.org/10.1016/j.clinbiochem.2015.06.013 https://doi.org/10.1016/j.clinbiochem.20...
] |
Unrelated Euro-Brazilian women |
Curitiba, PR |
TCF7L2 |
rs7903146; rs12255372 |
T; T |
0.295/0.360; 0.303/0.320 |
400 |
PUBMED |
Barros et al. (201453. Barros CMAR, Araujo- Neto AP, Lopes TR, Barros ML, Motta FJN, Canalle R, et al. Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil. Genet Mol Res . 2014;13(3):7889-98. https://doi.org/10.4238/2014.September.29.1 https://doi.org/10.4238/2014.September.2...
) [5353. Barros CMAR, Araujo- Neto AP, Lopes TR, Barros ML, Motta FJN, Canalle R, et al. Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil. Genet Mol Res . 2014;13(3):7889-98. https://doi.org/10.4238/2014.September.29.1 https://doi.org/10.4238/2014.September.2...
] |
Unrelated individuals from the general population |
Parnaíba, PI |
TCF7L2 |
rs7903146; rs12255372 |
T; T |
0.28/0.29; 0.28/0.22 |
220 |
PUBMED |
Assmann et al. (201454. Assmann TS, Duarte GC, Rheinheimer J, Cruz LA, Canani LH, Crispim D. The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil. Arq Bras Endocrinol Metabol . 2014;58(9):918-25. https://doi.org/10.1590/0004-2730000003510 https://doi.org/10.1590/0004-27300000035...
) [5454. Assmann TS, Duarte GC, Rheinheimer J, Cruz LA, Canani LH, Crispim D. The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil. Arq Bras Endocrinol Metabol . 2014;58(9):918-25. https://doi.org/10.1590/0004-2730000003510 https://doi.org/10.1590/0004-27300000035...
] |
T2D patients and non-diabetic subjects |
Porto Alegre, RS |
TCF7L2 |
rs7903146 |
T |
0.38; 0.31 |
1488 |
PUBMED |
Vaquero et al. (201245. Vaquero AR, Ferreira NE, Omae SV, Rodrigues MV, Teixeira SK, Krieger JE, et al. Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk. Physiol Genomics. 2012;44(19):903-14. https://doi.org/10.1152/physiolgenomics.00030.2012 https://doi.org/10.1152/physiolgenomics....
) [4545. Vaquero AR, Ferreira NE, Omae SV, Rodrigues MV, Teixeira SK, Krieger JE, et al. Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk. Physiol Genomics. 2012;44(19):903-14. https://doi.org/10.1152/physiolgenomics.00030.2012 https://doi.org/10.1152/physiolgenomics....
] |
Smooth muscle cells from human mammary artery segments |
São Paulo, SP |
TCF7L2 |
rs7903146 |
T |
0.288 |
92 |
PUBMED |
Franco et al. (201144. Franco LF, Crispim F, Pereira AC, Moisés RS; Japanese-Brazilian Diabetes Study Group. Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians. Braz J Med Biol Res. 2011;44(3):240-4. https://doi.org/10.1590/s0100-879x2011007500010 https://doi.org/10.1590/s0100-879x201100...
) [4444. Franco LF, Crispim F, Pereira AC, Moisés RS; Japanese-Brazilian Diabetes Study Group. Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians. Braz J Med Biol Res. 2011;44(3):240-4. https://doi.org/10.1590/s0100-879x2011007500010 https://doi.org/10.1590/s0100-879x201100...
] |
Individuals recruited from the Japanese-Brazilian Diabetes Study Group |
Bauru, SP |
TCF7L2 |
rs7903146; rs12255372 |
T; T |
0.051/0.055; 0.032/0.035 |
222 |
PUBMED |
Sousa et al. (200940. Sousa AGP, Marquezine GF, Lemos PA, Martinez E, Lopes N, Hueb WA, et al. TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. PLoS One. 2009;4(11):e7697. https://doi.org/10.1371/journal.pone.0007697 https://doi.org/10.1371/journal.pone.000...
) [4040. Sousa AGP, Marquezine GF, Lemos PA, Martinez E, Lopes N, Hueb WA, et al. TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. PLoS One. 2009;4(11):e7697. https://doi.org/10.1371/journal.pone.0007697 https://doi.org/10.1371/journal.pone.000...
] |
Individuals referred for cardiac catheterization for the diagnosis of CAD; MASS II study |
São Paulo, SP |
TCF7L2 |
rs7903146 |
T |
0.319; 0.416 |
1455 |
PUBMED |
Sousa (201143. Sousa AGP. Associação entre TCF7L2 e outras variantes genéticas de risco para diabetes mellitus tipo 2 e doença cardiovascular [tese]. São Paulo: Universidade de São Paulo; 2011.) [4343. Sousa AGP. Associação entre TCF7L2 e outras variantes genéticas de risco para diabetes mellitus tipo 2 e doença cardiovascular [tese]. São Paulo: Universidade de São Paulo; 2011.] |
Individuals undergoing cardiac catheterization and individuals with coronary artery disease from the MASS II study |
São Paulo, SP |
TCF7L2 |
rs7903146 |
T |
0.319; 0.416; 0.470 |
1455 |
BDTD |
Marquezine et al. (200838. Marquezine GF, Pereira AC, Sousa AGP, Mill JG, Hueb WA, Krieger JE. TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: Significant association, but not a significant tool for risk stratification in the general population. BMC Med Genet. 2008;9:106. https://doi.org/10.1186/1471-2350-9-106 https://doi.org/10.1186/1471-2350-9-106...
) [3838. Marquezine GF, Pereira AC, Sousa AGP, Mill JG, Hueb WA, Krieger JE. TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: Significant association, but not a significant tool for risk stratification in the general population. BMC Med Genet. 2008;9:106. https://doi.org/10.1186/1471-2350-9-106 https://doi.org/10.1186/1471-2350-9-106...
] |
Patients with documented multi-vessel coronary artery disease and normal left ventricular function (MASS II trial); general population of Vitoria, ES |
São Paulo, SP; Vitoria, ES |
TCF7L2 |
rs7903146 |
T |
0.416; 0.333 |
2143 |
PUBMED |
Marquezine (200939. Marquezine GF. Papel do polimorfismo rs7903146 do gene TCF7L2 na população brasileira e sua aplicação na predição de risco de diabetes tipo 2 [tese]. São Paulo: Universidade de São Paulo; 2009.) [3939. Marquezine GF. Papel do polimorfismo rs7903146 do gene TCF7L2 na população brasileira e sua aplicação na predição de risco de diabetes tipo 2 [tese]. São Paulo: Universidade de São Paulo; 2009.] |
Vitoria urban population; 33 districts of Ouro Preto; school children and their parents from Itapetininga; patients with coronary artery disease (MASS II) |
Vitória, ES; Ouro Preto, MG; Itapetininga, SP |
TCF7L2 |
rs7903146 |
T |
n/a |
4579 |
BDTD |
Barra et al. (201246. Barra GB, Dutra LAS, Watanabe SC, Costa PGG, Cruz PSM da, Azevedo MF, et al. Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects. Arq Bras Endocrinol Metabol . 2012;56(8):479-84. https://doi.org/10.1590/s0004-27302012000800003 https://doi.org/10.1590/s0004-2730201200...
) [4646. Barra GB, Dutra LAS, Watanabe SC, Costa PGG, Cruz PSM da, Azevedo MF, et al. Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects. Arq Bras Endocrinol Metabol . 2012;56(8):479-84. https://doi.org/10.1590/s0004-27302012000800003 https://doi.org/10.1590/s0004-2730201200...
] |
Subjects seen at the Brasilia University Hospital |
Brasilia, DF |
TCF7L2 |
rs7903146 |
T |
0.358; 0.270 |
252 |
SCIELO |
Oliveira (201962. Oliveira BA. Pacientes portadores de diabetes mellitus tipo 2 atendidos no Instituto de Previdencia e Assistencia do Município de Belem-IPAMB: Aspectos epidemiológicos e genéticos [dissertação]. Belém: Universidade Federal do Pará; 2019. ) [6262. Oliveira BA. Pacientes portadores de diabetes mellitus tipo 2 atendidos no Instituto de Previdencia e Assistencia do Município de Belem-IPAMB: Aspectos epidemiológicos e genéticos [dissertação]. Belém: Universidade Federal do Pará; 2019. ] |
Individuals with T2D or without previous diagnosis of any type of diabetes |
Belém, PA |
TCF7L2 |
rs7901695 |
C |
0.496 (0.505/0.476) |
147 |
BDTD |
Pinto (201859. Pinto IA. Polimorfismo rs7903146 do gene TCF7L2 e sua associação com alterações da homeostase da glicose em crianças da Grande Vitoria [dissertação]. Vitória: Universidade Federal do Espírito Santo; 2018. ) [5959. Pinto IA. Polimorfismo rs7903146 do gene TCF7L2 e sua associação com alterações da homeostase da glicose em crianças da Grande Vitoria [dissertação]. Vitória: Universidade Federal do Espírito Santo; 2018. ] |
Adolescents enrolled in state public schools |
Vitória, ES |
TCF7L2 |
rs7903146 |
T |
0.385 |
312 |
BDTD |
Catena (2016) [5757. Catena A S. Genotipagem e análise da expressão do gene TCF7L2 em pacientes com alteração do crescimento fetal e doenças metabólicas no adulto [dissertação]. Recife: Universidade Federal de Pernambuco; 2016. ] |
Patients from two cohorts, subdivided into newborns and adults |
João Pessoa, PB; Recife, PE |
TCF7L2 |
rs7901695; rs7903146; rs12255372 |
C; T; T |
0.389; 0.319; 0.277 |
149 |
BDTD |
Costa (2014) [5050. Costa C S. Avaliação dos polimorfismos rs7903146 e rs12255372 do gene TCF7L2 no desenvolvimento do Diabetes Mellitus Tipo 2 [dissertação]. Lajeado: Universidade do Vale do Taquari; 2014. ] |
Patients with T2D and healthy individuals |
Porto Alegre, RS |
TCF7L2 |
rs7903146; rs12255372 |
T; T |
0.36; 0.30/0.34; 0.31 |
579 |
BDTD |
da Rocha (201451. Rocha CR. Investigação da interação entre fatores ambientais e polimorfismos genéticos rs7903146 e rs12255372 do gene TCF7L2 no Diabetes Mellitus Tipo 2 [dissertação]. Lajeado: Centro Universitário UNIVATES; 2014. ) [5151. Rocha CR. Investigação da interação entre fatores ambientais e polimorfismos genéticos rs7903146 e rs12255372 do gene TCF7L2 no Diabetes Mellitus Tipo 2 [dissertação]. Lajeado: Centro Universitário UNIVATES; 2014. ] |
Individuals with T2D |
Vale do Taquari, RS |
TCF7L2 |
rs7903146; rs12255372 |
T; T |
0.402; 0.391 |
46 |
BDTD |
Cezar (201348. Cezar NJB. Participação de genes relacionados ao processo inflamatório no diabetes mellitus gestacional [dissertação]. Ribeirão Preto: Universidade de São Paulo; 2013.) [4848. Cezar NJB. Participação de genes relacionados ao processo inflamatório no diabetes mellitus gestacional [dissertação]. Ribeirão Preto: Universidade de São Paulo; 2013.] |
Patients with GD and pregnant women with no history of GD |
Ribeirão Preto, SP |
TCF7L2 |
n/a |
n/a |
n/a |
28 |
BDTD |
Ferreira (201349. Ferreira MC. Análise da resposta hormonal pancreática antes e após tratamento com GLP-1 mimético em indivíduos com diabetes tipo 2 portadores da variante rs7903146 do gene TCF7L2 [tese]. São Paulo: Universidade de São Paulo; 2013.) [4949. Ferreira MC. Análise da resposta hormonal pancreática antes e após tratamento com GLP-1 mimético em indivíduos com diabetes tipo 2 portadores da variante rs7903146 do gene TCF7L2 [tese]. São Paulo: Universidade de São Paulo; 2013.] |
T2D patients and individuals without diabetes and without T2D family history from the DNA bank at University of São Paulo |
São Paulo, SP |
TCF7L2 |
rs7903146 |
T |
0.335 |
302 |
BDTD |
Moraes (201347. Moraes TI Relação entre polimorfismos dos genes LEP, FTO, APOA5, ADRB3, TCF7L2, ENPP1, CYP11B2 e PPARG e a síndrome metabólica [dissertação]. São Paulo: Universidade de São Paulo; 2013. ) [4747. Moraes TI Relação entre polimorfismos dos genes LEP, FTO, APOA5, ADRB3, TCF7L2, ENPP1, CYP11B2 e PPARG e a síndrome metabólica [dissertação]. São Paulo: Universidade de São Paulo; 2013. ] |
Individuals recruited at the University Hospital of the University of São Paulo |
São Paulo, SP |
TCF7L2 |
rs7903146 |
T |
0.354; 0.321 |
429 |
BDTD |
Silva (201142. Silva MVCM. Análise genético-populacional das mutações do gene TCF7L2 em diabéticos de Triunfo, Pernambuco [dissertação]. Recife: Universidade de Pernambuco; 2011. ) [4242. Silva MVCM. Análise genético-populacional das mutações do gene TCF7L2 em diabéticos de Triunfo, Pernambuco [dissertação]. Recife: Universidade de Pernambuco; 2011. ] |
Diabetic and healthy individuals |
Triunfo, PE |
TCF7L2 |
rs7901695; rs7903146; rs11196205; rs12255372 |
C; T; C; T |
0.528/0.435; 0.344/0.306; 0.587/0.626; 0.398/0.323 |
340 |
BDTD |
da Silva Filho (201041. Silva Filho RL. Epidemiologia e genética molecular do diabetes mellitus tipo 2 no município de Triunfo, Pernambuco [tese]. Recife: Universidade de Pernambuco; 2010. ) [41] |
Diabetics and non-diabetics |
Triunfo, PE |
TCF7L2 |
rs7901695; rs7903146; rs11196205; rs12255372 |
C; T; C; T |
0.528/0.435; 0.344/0.306; 0.587/0.626; 0.398/0.323 |
340 |
BDTD |
Frigeri (201526. Frigeri HR. Variabilidade genética e sequenciamento de genes associados ao diabetes mellitus tipo 2 e à obesidade [tese]. Curitiba: Universidade Federal do Paraná; 2015. ) [2626. Frigeri HR. Variabilidade genética e sequenciamento de genes associados ao diabetes mellitus tipo 2 e à obesidade [tese]. Curitiba: Universidade Federal do Paraná; 2015. ] |
Biorepository samples |
Curitiba, PR |
TCF7L2 |
rs7901695 |
C |
0.338; 0.387 |
313 |
BDTD |
Welter (201452. Welter M. Variabilidade de genes e biomarcadores de controle glicêmico associados ao Diabetes Mellitus Tipo 2 [dissertação]. Curitiba: Universidade Federal do Paraná; 2014. ) [5252. Welter M. Variabilidade de genes e biomarcadores de controle glicêmico associados ao Diabetes Mellitus Tipo 2 [dissertação]. Curitiba: Universidade Federal do Paraná; 2014. ] |
T2D patients and healthy individuals |
Curitiba, PR |
TCF7L2 |
rs7903146; rs12255372 |
T; T |
0.340/0.310; 0.330/0.280 |
241 |
BDTD |
Welter et al. (201577. Welter M, Frigeri HR, Réa RR, Souza EM, Alberton D, Picheth G, et al. The rs10885122 polymorphism of the adrenoceptor alpha 2A (ADRA2A) gene in Euro-Brazilians with type 2 diabetes mellitus. Arch Endocrinol Metab . 2015;59(1):29-33. https://doi.org/10.1590/2359-3997000000006 https://doi.org/10.1590/2359-39970000000...
) [7777. Welter M, Frigeri HR, Réa RR, Souza EM, Alberton D, Picheth G, et al. The rs10885122 polymorphism of the adrenoceptor alpha 2A (ADRA2A) gene in Euro-Brazilians with type 2 diabetes mellitus. Arch Endocrinol Metab . 2015;59(1):29-33. https://doi.org/10.1590/2359-3997000000006 https://doi.org/10.1590/2359-39970000000...
] |
Unrelated Euro-Brazilian subjects |
Curitiba, PR |
ADRA2A |
rs10885122 |
T |
0.20/0.19 |
241 |
PUBMED |
Welter (201452. Welter M. Variabilidade de genes e biomarcadores de controle glicêmico associados ao Diabetes Mellitus Tipo 2 [dissertação]. Curitiba: Universidade Federal do Paraná; 2014. ) [5252. Welter M. Variabilidade de genes e biomarcadores de controle glicêmico associados ao Diabetes Mellitus Tipo 2 [dissertação]. Curitiba: Universidade Federal do Paraná; 2014. ] |
T2D patients and healthy individuals |
Curitiba, PR |
ADRA2A; SLC2A2 |
rs10885122; rs5393 |
T; C |
0.20/0.19; 0.21/0.20 |
241 |
BDTD |
Weiss (201476. Weiss ICRS. Variabilidade genética e biomarcadores associados ao diabetes gestacional [tese]. Curitiba: Universidade Federal do Paraná; 2014. ) [7676. Weiss ICRS. Variabilidade genética e biomarcadores associados ao diabetes gestacional [tese]. Curitiba: Universidade Federal do Paraná; 2014. ] |
Pregnant women |
Curitiba, PR |
ADRA2A; SLC2A2 |
rs10885122; rs5393 |
T; G |
0.210/0.200; 0.190/0.180 |
814 |
BDTD |
Anghebem-Oliveira et al. (201766. Anghebem-Oliveira MI, Webber S, Alberton D, Souza EM, Klassen G, Picheth G, et al. The GCKR gene polymorphism rs780094 is a risk factor for gestational diabetes in a Brazilian population. J Clin Lab Anal. 2017;31(2):e22035. https://doi.org/10.1002/jcla.22035 https://doi.org/10.1002/jcla.22035...
) [5858. Anghebem-Oliveira MI, Martins BR, Alberton D, Ramos EA S, Picheth G, Rego FG de M. Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population. Arch Endocrinol Metab . 2017;61(3):238-48. https://doi.org/10.1590/2359-3997000000258 https://doi.org/10.1590/2359-39970000002...
] |
Unrelated Euro-Brazilian pregnant women |
Curitiba, PR |
GCKR |
rs780094 |
T |
0.307/0.384 |
252 |
PUBMED |
Anghebem-Oliveira (201555. Anghebem-Oliveira MI. Avaliação de biomarcadores e variantes genéticas no Diabetes Mellitus Tipo 1, Tipo 2 e gestacional [tese]. Curitiba: Universidade Federal do Paraná; 2015. ) [5555. Anghebem-Oliveira MI. Avaliação de biomarcadores e variantes genéticas no Diabetes Mellitus Tipo 1, Tipo 2 e gestacional [tese]. Curitiba: Universidade Federal do Paraná; 2015. ] |
Healthy individuals, patients with T1D, T2D or GD, samples from the UFPR Clinical Biochemistry Laboratory |
Curitiba, PR |
GCKR |
rs780094 |
C |
0.693/0.616 |
967 |
BDTD |
Junior (2014) [7575. Lobo Junior JP. Produtos finais de glicação avançada fluorescentes (AGEs-F) e polimorfismos dos genes MIF, MTNR1B e CDKAL1 no diabetes gestacional [dissertação]. Curitiba: Universidade Federal do Paraná; 2014. ] |
Pregnant women healthy and with GD |
Curitiba, PR |
MTNR1B |
rs10830963 |
G |
0.276/0.202 |
442 |
BDTD |
von Kostrisch (201678. Kostrisch LMV. Contribuição dos polimorfismos rs10830963 e rs1387153 no gene da melatonina para ocorrência de diabetes mellitus gestacional e fissuras labiopalatinas [tese]. Bauru: Universidade de São Paulo; 2016. ) [7878. Kostrisch LMV. Contribuição dos polimorfismos rs10830963 e rs1387153 no gene da melatonina para ocorrência de diabetes mellitus gestacional e fissuras labiopalatinas [tese]. Bauru: Universidade de São Paulo; 2016. ] |
Mothers and their children |
Bauru, SP |
MTNR1B |
rs10830963; rs1387153 |
G; T |
n/a |
400 |
BDTD |
Lima (201869. Lima PNB. Polimorfismo de nucleotídeo único no gene do ZNT8 (rs11558471) e sua relação com o estado nutricional relativo ao zinco e marcadores glicêmicos em indivíduos com Diabetes Mellitus Tipo 2 [dissertação]. Aracajú: Universidade Federal de Sergipe; 2018. ) [6969. Lima PNB. Polimorfismo de nucleotídeo único no gene do ZNT8 (rs11558471) e sua relação com o estado nutricional relativo ao zinco e marcadores glicêmicos em indivíduos com Diabetes Mellitus Tipo 2 [dissertação]. Aracajú: Universidade Federal de Sergipe; 2018. ] |
Volunteers with T2D |
Aracaju, SE |
SLC30A8 |
rs11558471 |
A |
0.768 |
110 |
BDTD |
Gomes et al. (201767. Gomes KFB, Semzezem C, Batista R, Fukui RT, Santos AS, Correia MR, et al. Importance of Zinc Transporter 8 Autoantibody in the Diagnosis of Type 1 Diabetes in Latin Americans. Sci Rep. 2017;7(1):207. https://doi.org/10.1038/s41598-017-00307-4 https://doi.org/10.1038/s41598-017-00307...
) [6767. Gomes KFB, Semzezem C, Batista R, Fukui RT, Santos AS, Correia MR, et al. Importance of Zinc Transporter 8 Autoantibody in the Diagnosis of Type 1 Diabetes in Latin Americans. Sci Rep. 2017;7(1):207. https://doi.org/10.1038/s41598-017-00307-4 https://doi.org/10.1038/s41598-017-00307...
] |
T1D patients and healthy controls |
São Paulo, SP |
SLC30A8 |
rs2466295; rs16889462 |
G; A |
n/a |
1280 |
PUBMED |
Teleginski et al. (201768. Teleginski A, Welter M, Frigeri HR, Réa RR, Souza EM, Alberton D, et al. Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes. Genet Mol Res . 2017;16(1). https://doi.org/10.4238/gmr16019515 https://doi.org/10.4238/gmr16019515...
) [6868. Teleginski A, Welter M, Frigeri HR, Réa RR, Souza EM, Alberton D, et al. Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes. Genet Mol Res . 2017;16(1). https://doi.org/10.4238/gmr16019515 https://doi.org/10.4238/gmr16019515...
] |
Unrelated Euro-Brazilian pregnant women |
Curitiba, PR |
SLC30A8 |
rs13266634 |
A; T |
0.366/0.403; 0.235/0.278 |
314 |
PUBMED |
Bandeira (201665. Bandeira VS. Influência do polimorfismo Arg325Trp no gene do ZNT8 (SLC30A8) no estado nutricional relativo ao zinco de pacientes com Diabetes Tipo 2 e sua relação com parâmetros glicêmicos e insulinêmicos [dissertação]. São Paulo: Universidade de São Paulo; 2016.) [6565. Bandeira VS. Influência do polimorfismo Arg325Trp no gene do ZNT8 (SLC30A8) no estado nutricional relativo ao zinco de pacientes com Diabetes Tipo 2 e sua relação com parâmetros glicêmicos e insulinêmicos [dissertação]. São Paulo: Universidade de São Paulo; 2016.] |
T2D patients |
São Paulo, SP |
SLC30A8 |
rs13266634 |
T |
0.280 |
82 |
BDTD |
Frigeri (201526. Frigeri HR. Variabilidade genética e sequenciamento de genes associados ao diabetes mellitus tipo 2 e à obesidade [tese]. Curitiba: Universidade Federal do Paraná; 2015. ) [2626. Frigeri HR. Variabilidade genética e sequenciamento de genes associados ao diabetes mellitus tipo 2 e à obesidade [tese]. Curitiba: Universidade Federal do Paraná; 2015. ] |
Biorepository samples |
Curitiba, PR |
GCKR; SLC30A8 |
rs780094; rs13266634 |
T; T |
0.396/0.394; 0.227/0.255 |
313 |
BDTD |