Acessibilidade / Reportar erro
Review article • Arc. Clin. Psychiatr. 43 (5) • Sep-Oct 2016 • https://doi.org/10.1590/0101-60830000000097   copy

Interventions for music performance anxiety: results from a systematic literature review

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Background

Music performance anxiety (MPA) is characterised by fears related to performing music. It may result in damages to personal life and professional career, so treatment and prevention are very important.

Objective

To undertake a systematic literature review on the effectiveness/efficacy of MPA interventions and to integrate these findings to those in the literature reviewed previously.

Methods

We used PubMed, PsycINFO and SciELO databases and keywords music*, performance anxiety, treatment, therapy and intervention and manual research. We selected articles published between October-2002/July-2016.

Results

Out of 97 articles, 23 were reviewed. Sixteen studies presented inter-group experimental design, and seven presented pre-post experimental design. The intervention modalities reviewed were cognitive behavioural therapy (CBT), virtual reality exposure, biofeedback, yoga, meditation, music therapy and the Alexander technique. Although the interventions presented some indicators of efficacy in the MPA outcomes and improvement in performance quality, important methodological limitations were observed: low number of individuals and non-specific criteria for their inclusion/exclusion. This reinforces previous findings regarding methodological fragilities associated with this context.

Discussion

CBT is the most frequently studied modality and with the greatest number of effectiveness indicators. The remaining modalities indicate tendencies in positive outcomes that require further and efficient investigation in more rigorous studies with greater methodological control.

Music performance anxiety; interventions; treatment; therapy; systematic review

Introduction

Music performance anxiety (MPA) is considered a subtype of social anxiety disorder. It is typified by the presence of specific fears related to performing music11. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition, Washington DC, London – England 2013., and it can be related to both solo and group presentations, as well as to any instrument, including singing22. Papageorgi I, Hallam S, Welch GF. A conceptual framework for understanding musical performance anxiety. Res Stud Music Educ. 2007;28(1):83-107.

3. Ryan C, Andrews N. An investigation into the choral singer’s experience of music performance anxiety. J Res Music Educ. 2009;57(2):108-26.-44. Taborsky C. Musical performance anxiety: a review of literature. Update: Appl Res Music Educ. 2007;26:15-25.MPA can impact not only the performance itself but also the musician’s career and quality of life55. Yondem ZD. Performance anxiety, dysfunctional attitudes and gender in university music students. J Soc Behav Pers. 2007;35(10):1415-26.,66. Kenny DT. The psychology of music performance anxiety. Oxford: Oxford University Press; 2011.therefore, representing a condition that requires the attention of clinicians in its recognition and treatment.

Although MPA has been a part of the human experience for a long time, it was not until the 1970s that medical and psychological treatment and intervention-related research started being conducted. Among these treatments and interventions, behavioural and cognitive behavioural therapies, pharmacological interventions (mainly beta blockers), biofeedback, meditation and music therapy all stand out. There has been a focus on adult musicians, as observed by two previous literature reviews, one of which was systematic77. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208.and the other was non-systematic88. Brugues AO. Music performance anxiety – part 2. A review of treatment options. Med Probl Perform Art. 2011;26(3):164-71..

The results of these reviews denote some evidence of effectiveness. When behavioural and cognitive behavioural therapies were considered, a reduction in MPA and improvement in music performance quality was found77. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208.. Combined interventions, such as cognitive behavioural therapy associated with biofeedback and progressive muscle relaxation, were also found to have positive effects on decreasing MPA, as did the use of beta blockers77. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208.,88. Brugues AO. Music performance anxiety – part 2. A review of treatment options. Med Probl Perform Art. 2011;26(3):164-71..

According to Kenny77. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208., an important factor to consider is the methodological fragility of the studies carried out in this context, particularly in terms of the low number of participants and of experimental inter-group crossover studies, the lack of rigour in the methods used and the non-standardisation of the instruments utilised in outcome assessment.

The aforementioned reviews concluded that this field has yet to be explored through new research, which should focus on the methodological refinements necessary in order to create stronger evidence on the efficacy of MPA-related treatments.

It is known that a) the results on the effectiveness of different interventions presented thus far have been inconclusive; b) the reviews published till date77. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208.,88. Brugues AO. Music performance anxiety – part 2. A review of treatment options. Med Probl Perform Art. 2011;26(3):164-71.did not include studies that assess children and adolescents (which seems important, as MPA may begin in infancy or adolescence, and as early interventions in this group may prevent suffering and negative effects on their musical careers as adults); and c) new studies are still being published. Given these factors, we propose this present study, the aim of which is to undertake a systematic literature review seeking a) to assess the efficacy and effectiveness of MPA treatments/interventions in children, adolescents and adults and b) to integrate the current findings into the body of knowledge from the previously reviewed literature.

Material and methods

This study was carried out in accordance with the guidelines set in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses99. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 2009;6(7):e1000097. and in the Cochrane Handbook for Systematic Reviews of Interventions1010. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. The Cochrane Collaboration. 2011. Available at: <http://www.cochrane.org/handbook>. Accessed on: Jul 31. 2015.
http://www.cochrane.org/handbook... . A systematic search was performed in the PsycINFO, PubMed and SciELO electronic databases, using the following keywords: (Music* Performance Anxiety) and (treatment or therapy or intervention). Articles published from October 2002 (the date of the latest article included in the systematic literature review conducted by Kenny in 200577. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208. onwards were included, wherein the last search was performed in July 2016. The article inclusion and exclusion process followed the criteria shown in Figure 1.

Figure 1
Flowchart regarding the inclusion/exclusion of articles of the review presented.

As shown in Figure 1, 97 articles were found. After applying the inclusion and exclusion criteria, 19 articles were selected, which were independently evaluated in terms of their relevance by two professionals with experience in the field of anxiety. Out of the 19 articles, five were found to have been repeated, which result in a total of 14 articles. Thereafter, a search was performed in handbooks and periodicals specific to the music field (Research in Musical Behaviour, the Journal of Research in Music Education, Medical Problems of Performing Artists, Psychology of Music and Music Education and the Journal of Music Therapy), as well as in the bibliographical references of the articles selected, from which nine new articles were found. Therefore, a total of 23 articles were chosen to be analysed1111. Osborne MS, Kenny DT, Cooksey J. Impact of a cognitive-behavioural treatment program on music performance anxiety in secondary school music students: A pilot study. Music Sci Special issue. 2007;11(2):53-84.

12. Bien Aime JK. Managing performance anxiety in music students: using a solution focused approach. (Doctoral Dissertation). Nova Southeastern University, USA; 2011.

13. Clark T, Williamon A. Evaluation of mental skills training program for musicians. J Appl Sport Psychol. 2011;23(3):342-59.

14. Errico AS. The effects of a researcher-designed intervention on elementary students music performance anxiety levels. (Doctoral Dissertation); 2012.

15. Hoffman SL, Hanrahan J. Mental Skills for Musicians: Managing Music Performance Anxiety and Enhancing Performance. Sport Exerc Perform Psychol. 2012;1(1):17-28.

16. Braden AM, Osborne MS, Wilson SJ. Psychological intervention reduces self-reported performance anxiety in high school music students. Front Psychol. 2015;6:195.

17. Khalsa SB, Cope S. Effects of yoga lifestyle intervention on performance-related characteristics of musicians: a preliminary study. Med Sci Monit. 2006;12(8):CR325-31.

18. Khalsa SB, Shorter SM, Cope S, Wyshak G, Sklar E. Yoga ameliorates performance anxiety and mood disturbance in young professional musicians. Appl Psychophysiol Biofeedback. 2009;34(4):279-89.

19. Stern JR, Khalsa SB, Hoffman SG. A yoga intervention for music performance anxiety in conservatory students. Med Prob Perform Art. 2012;27(3):123-8.

20. Khalsa SB, Butzer B, Shorter SM, Reinhardt KM, Cope S. Yoga reduces performance anxiety in adolescent musicians. Altern Ther Health Med. 2013;19(2):34-45.

21. Thurber MR. Effects of heart-rate variability biofeedback training and emotional regulation on music performance anxiety in university students. (Doctoral Dissertation); 2006.

22. Silvana M, Pop-Jordanova N, Georgiev D. Simultaneous EEG and EMG biofeedback for peak performance in musicians. Prilozi. 2008;29(1):239-52.

23. Wells R, Outhred T, Healthers JA, Quintana DS, Kemp AH. Matter over mind: a randomized-controlled trial of single-session biofeedback training on performance anxiety and heart rate variability in musicians. PLoS One. 2012;7(10):e46597.

24. Chang JC, Midlarsky E, Lin P. The effects of meditation on music performance anxiety. Med Probl Perform Art. 2003;18(3):126-30.

25. Lin P, Chang J, Zemon V, Midlarsky E. Silent illumination: A study on Chan (Zen) meditation, anxiety, and musical performance quality. Psychol Music. 2008;36(2):139-55.

26. Su YH, Luh JJ, Chen HI, Lin CC, Liao MJ, Chen HS. Effects of using relaxation breathing training to reduce music performance anxiety in 3rd to 6th graders. Med Probl Perform Art. 2010;25(2):82-6.

27. Sousa CM, Goncalves M, Machado F, Efferth T, Greten T, Froeschen P, et al. Effects of qigong on performance-related anxiety and physiological stress functions in transverse flute music schoolchildren: a feasibility study. Zhong Xi Yi Jie He Xue Bao. 2012;10(8):858-65.

28. Orman EK. Effect of virtual reality graded exposure on heart rate self-reported anxiety. J Res Music Educ. 2003;51(4):302-15.

29. Bissonnette J, Dubé F, Provencher MD, Sala MTM. The effect of virtual training on music performance anxiety. International Symposium on Performance Science 2011 [PMID: 26395619].

30. Conklin NM. Musical performance anxiety in virtual performances: a comparison of recorded and live performance contexts. (Doctoral Dissertation). University of Oklahoma, USA, 2011.

31. Kim Y. Combined treatment of improvisation and desensitization to alleviate music performance anxiety in female college pianists: A pilot study. Med Probl Perform Art. 2005;20(1):17-24.

32. Kim Y. The effect of improvisation-assisted desensitization, and music-assisted progressive muscle relaxation and imagery on reducing pianists’ music performance anxiety. J Music Ther. 2008;45(2):165-91.-3333. Hoberg A. Reducing performance anxiety in woodwind playing through the application of the Alexander Technique principles. Pretoria, South Africa: University of Pretoria, Department of Music; Master’s Thesis; 2008.. For studies that show crude numeric data, the size effect of significant differences was calculated. We used the Cohen statistics.

Results

Of the 23 studies analysed, most were conducted in the United States (n = 11) and in Australia (n = 4). The intervention modalities studied by the articles were, in descending order: cognitive behavioural therapy (n = 6), yoga (n = 4), meditation (n = 4), virtual reality exposure (n = 3), biofeedback (n = 3), music therapy (n = 2) and the Alexander technique (n = 1). It was found that none of the studies assessed combined interventions pertaining to different modalities and that the interventions assessed were not standardised in terms of duration, session frequency or technique utilised.

Concerning design, in accordance with the inclusion criteria adopted, all of the studies were clinical (experimental). Out of these studies, most (n = 16) employed the intergroup modality (case control), and less than half were randomised (n = 7). The remainder (n = 7) had a pre-experimental design (pre- and post-intervention assessment) with a single group.

The samples were composed of varying numbers of subjects, with a minimum of four and a maximum of 162 (experimental group: mean 21.8 and median 14; control group: mean 19.9 and median 9).

Most of the studies used both genders in their clinical samplings (n = 14); five studied only adolescents, and one studied only children. The remainder focused on young adults.

Most of the subjects had been recruited in music schools and courses, and most of them were music students (n = 19). No study assessed interventions using exclusively professional musicians. It was noted that the musical instruments played by the musicians varied, with a predominance of the piano (approximately 176 subjects), followed by wind instruments (approximately 119 subjects) and string instruments (approximately 103 subjects).

Few studies were clear as to the criteria adopted for the inclusion and exclusion of subjects (n = 2). Similarly, many studies failed to consider the level of MPA demonstrated by the subjects (whether pathological or considered within an acceptable level of normality).

In the 16 studies with an inter-group experimental design, the control groups were, in general, quite consistent with the socio-demographic characteristics of the experimental group in question, though, as mentioned, these studies often did not monitor the extent of MPA as a variable. The subjects in the control group were recruited from the same locations as those in the experimental groups, meaning they were also music students.

This information can be viewed in Table 1.

Thumbnail
Table 1
Socio-demographic characterisation of the samples and methodological aspects used in the studies assessed in the present review

The effectiveness of the interventions analysed was also considered. The results are summarised in Tables 2 and 3. This data can also be seen in more detail in the Supplementary Material.

Thumbnail
Supplementary Material
: Main results from the studies included in the present review, according to the different outcome variables

The effectiveness of cognitive behavioural therapy (Table 2) was evaluated based on 10 different outcomes. In two studies, a decrease in MPA was found, as were improvements in performance (N = 2), self-efficacy (N = 2) and self-confidence (N = 2), with effect size evaluated as medium-very large. It is important to indicate that one of the studies which showed a decrease in MPA was conducted on adolescents1616. Braden AM, Osborne MS, Wilson SJ. Psychological intervention reduces self-reported performance anxiety in high school music students. Front Psychol. 2015;6:195.. However, these findings are not unanimous among the studies, as around half did not find changes to these variables following the cognitive behavioural therapy intervention. This evidence was found to be more present in pre-experimental studies (pre- and post-intervention). It was also found that there was a relative variability in the instruments utilised to assess the different outcomes.

Thumbnail
Table 2
Results of Cognitive Behavioural Therapy, Virtual Reality Exposure and Biofeedback interventions on different outcome variables

Virtual reality exposure was also considered. Table 2 shows that the main positive results point to decreases in MPA, discomfort, confidence and heart rate; however, these outcomes were evaluated in three different studies2828. Orman EK. Effect of virtual reality graded exposure on heart rate self-reported anxiety. J Res Music Educ. 2003;51(4):302-15.

29. Bissonnette J, Dubé F, Provencher MD, Sala MTM. The effect of virtual training on music performance anxiety. International Symposium on Performance Science 2011 [PMID: 26395619].-3030. Conklin NM. Musical performance anxiety in virtual performances: a comparison of recorded and live performance contexts. (Doctoral Dissertation). University of Oklahoma, USA, 2011.with a pre-experimental design and a restricted number of subjects. These results, despite showing robust effects sizes, do not allow conclusions, only point to possible trends.

When the biofeedback intervention was considered, no alterations were found in the outcomes for subjective anxiety, whether general or performance-related (Table 2). Two experimental-type studies2121. Thurber MR. Effects of heart-rate variability biofeedback training and emotional regulation on music performance anxiety in university students. (Doctoral Dissertation); 2006.,2222. Silvana M, Pop-Jordanova N, Georgiev D. Simultaneous EEG and EMG biofeedback for peak performance in musicians. Prilozi. 2008;29(1):239-52.showed improvements in different neurophysiological variables.

Yoga was also used as an intervention technique. Table 3 shows that, unlike the others, this group of studies tended to use the same instruments to evaluate outcomes, a factor which is considered positive. Although they all reported improved MPA indicators in one way or another, only two of the experimental studies1717. Khalsa SB, Cope S. Effects of yoga lifestyle intervention on performance-related characteristics of musicians: a preliminary study. Med Sci Monit. 2006;12(8):CR325-31.,2020. Khalsa SB, Butzer B, Shorter SM, Reinhardt KM, Cope S. Yoga reduces performance anxiety in adolescent musicians. Altern Ther Health Med. 2013;19(2):34-45.truly presented efficacy indicators on this level (one of these studies was conducted on adolescents), with medium effects sizes. There was no evidence of changes to the indicators of general mood, stress, disposition, sleep or musculoskeletal disorders except in one study2020. Khalsa SB, Butzer B, Shorter SM, Reinhardt KM, Cope S. Yoga reduces performance anxiety in adolescent musicians. Altern Ther Health Med. 2013;19(2):34-45., in which the severity levels of these disorders decreased. However the effect size is little (d = 0.02).

Thumbnail
Table 3
Results of Yoga, Meditation, Music Therapy and Alexander technique interventions on different outcome variables

Meditation was also used as an intervention. Table 3 shows that limited evidence on effectiveness was found, with the exception of MPA and heart rate outcomes, in which positive alterations were found in isolated form in the studies2424. Chang JC, Midlarsky E, Lin P. The effects of meditation on music performance anxiety. Med Probl Perform Art. 2003;18(3):126-30.,2525. Lin P, Chang J, Zemon V, Midlarsky E. Silent illumination: A study on Chan (Zen) meditation, anxiety, and musical performance quality. Psychol Music. 2008;36(2):139-55.,2727. Sousa CM, Goncalves M, Machado F, Efferth T, Greten T, Froeschen P, et al. Effects of qigong on performance-related anxiety and physiological stress functions in transverse flute music schoolchildren: a feasibility study. Zhong Xi Yi Jie He Xue Bao. 2012;10(8):858-65.. It is important to note that the study2727. Sousa CM, Goncalves M, Machado F, Efferth T, Greten T, Froeschen P, et al. Effects of qigong on performance-related anxiety and physiological stress functions in transverse flute music schoolchildren: a feasibility study. Zhong Xi Yi Jie He Xue Bao. 2012;10(8):858-65. involved adolescents and, though experimental, had quite a small sample size (n < 19).

Table 3 also shows that with regards to music therapy, the only two studies which were assessed reported positive evidence only in terms of the decrease in state anxiety (effect size: 0.72-1.14). Concerning the remaining variables, Kim’s study3232. Kim Y. The effect of improvisation-assisted desensitization, and music-assisted progressive muscle relaxation and imagery on reducing pianists’ music performance anxiety. J Music Ther. 2008;45(2):165-91.indicates improved MPA, stress and tension; however, it was a pre-experimental study which only assessed 20 subjects.

Finally, it is important to note that only one study evaluated the Alexander technique. This study reported improvements in anxiety, physiological symptoms and musculoskeletal symptoms. The significance of these improvements was not assessed from a static perspective in this study.

In an attempt to integrate the findings of this current review with those from previous reviews, we have grouped together the different interventions and the main evidence on effectiveness by the outcome assessed. This data can be seen in Table 4.

Thumbnail
Table 4
Comparative analyses of the studies included in three reviews of the literature on the effectiveness of MPA interventions, in terms of the different outcome variables analysed (categories are non-exclusive)

The principal intervention modality, which was found to produce positive results for the treatment of MPA in both the previous and current reviews, was behavioural and/or cognitive therapies. It is also important to note that the main effect shown was the reduction in MPA (10 out of 19 studies). The current review has also found evidence of a positive effect on this outcome, as well as on performance quality, self-efficacy and trait anxiety levels, an observation which supports the previous findings, with medium effects size. Nonetheless, it must be noted that the positive findings were not unanimous in any of the reviews, as some of the studies did not show favourable results.

The current review found that other intervention modalities have been attracting a greater interest from researchers, with some signs/tendencies of effectiveness in MPA treatment. These interventions include yoga, virtual reality exposure, biofeedback and music therapy. It is in this way that new tendencies in interventions are revealed; these interventions need to be systematically assessed to determine their efficacy in the treatment of MPA.

Discussion

The impact of MPA on musicians is a frequently referred topic in literature worldwide55. Yondem ZD. Performance anxiety, dysfunctional attitudes and gender in university music students. J Soc Behav Pers. 2007;35(10):1415-26.,66. Kenny DT. The psychology of music performance anxiety. Oxford: Oxford University Press; 2011.,3434. Barbar AE, Souza Crippa JA de, Lima Osório F de. Performance anxiety in Brazilian musicians: prevalence and association with psychopathology indicators. J Affect Disord. 2014;152-154:381-6.as is the need for studies which assess ways to treat and minimise this type of anxiety3535. McGinnis AM, Milling AL. Psychological treatment of musical performance anxiety: current status and future directions. Psychother Theor Res Pract Train. 2005;42(3):357-73.. Thus, a relatively low number of studies performed thus far have aimed to assess the effectiveness of interventions to combat MPA, particularly if one considers the diversity of interventions and outcomes analysed and the limited number of subjects exposed to the interventions. This is strongly reflected in the quality and level of evidence observed and compiled by the reviews.

It is also important to point out that different fields of research outside health/medicine are increasingly considering this topic. These new approaches deserve attention, since MPA isa largely pathological condition associated with anxiety disorders. In the same vein, it is important to note that, to our knowledge, no study has been developed over the last 13 years with the aim of testing psychotropic drugs for MPA treatment.

Most of the studies have been published in periodicals in the music field or in the form of theses and dissertations, and that does not always guarantee a critical peer review. Furthermore, it is worth mentioning that the studies analysed continue to present important methodological weaknesses, as was mentioned by the previous reviews77. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208.,88. Brugues AO. Music performance anxiety – part 2. A review of treatment options. Med Probl Perform Art. 2011;26(3):164-71..

Thus, a large portion of the evidence presented herein requires careful interpretation, as it is not associated with experimental studies with inter-group comparisons. It is also important to note that most of the studies offer no information on the MPA levels experienced by the subjects, especially whether these levels were pathological. This information is essential for coming to conclusions on the success of the interventions analysed. Further limitations at this level are the low number of subjects studied, samples restricted mainly to young adults and music students, the lack of or failure to use subject randomisation, the lack of standardisation in the techniques used and in the duration of each intervention, the use of some non-validated instruments for outcome assessment and the presence of descriptive and non-statistical analyses of the results.

Another point to be considered involves the wide variety of instruments used to gauge the same outcome variables. An attempt to standardise the instruments used may be promising in that it will aid in the comparison of the evidence found, particularly in cases of meta-analyses.

Once these important methodological considerations are applied, one is able to focus on specific results regarding the interventions, which include more traditional and well-established interventions for different anxiety disorders, such as the cognitive behavioural therapy3636. Otte C. Cognitive behavioral therapy in anxiety disorders: current state of the evidence. Dialogues Clin Neurosci. 2011;13(4):413-21.and virtual reality exposure3737. Meyerbroker K, Emmelkamp PMG. Virtual reality exposure therapy in anxiety disorders: a systematic review of process and outcome studies. Depress Anxiety. 2010;27(10):933-44., as well as interventions that have not been fully endorsed in the literature for use in health care, such as meditation, music therapy, biofeedback, yoga and the Alexander technique.

With respect to the cognitive behavioural interventions, the results from the studies analysed partially support the positive findings previously indicated by earlier reviews, particularly in terms of the reductionsin MPA and trait anxiety rates and improvements in performance quality and self-efficacy.

Cognitive behavioural interventions are psychotherapy modalities comprising different cognitive restructuring techniques which aim to alter thought patterns which are considered dysfunctional3838. Knapp P, Beck AT. Fundamentos, modelos conceituais, aplicações e pesquisa da terapia cognitiva. Rev Bras Psiquiatr. 2008;30(Supl II):S54-64.. These thought patterns are common to individuals with anxiety3939. Beck AT, Emery G, Greenber RL. Anxiety disorders and phobia: a cognitive perspective. New York: Basic Books; 1985.and are particularly common among musicians with MPA66. Kenny DT. The psychology of music performance anxiety. Oxford: Oxford University Press; 2011.. Another aim of these interventions is to improve social and assertiveness abilities, which are usually limited in these clinical groups4040. Ito LM, Roso MC, Tiwari S, Kendall PC, Asbahr FR. Terapia cognitivo-comportamental da fobia social. Rev Bras Psiquiatr. 2008;30(Supl II):S96-101.. Other resources are also used, such as mental rehearsal techniques and strategies for anxiety coping and relaxation, which favour management and better control over anxiety symptoms. Such interventions are recognised as one of the gold standards for anxiety disorder treatment4141. Hofmann SG, Smits, JAJ. Cognitive-Behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry. 2008;69(4):621-32..

Considering the fact that MPA is a subtype of social anxiety disorder11. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition, Washington DC, London – England 2013., the findings on this specific condition are backed by this wider context. However, when the three reviews on the topic were compared, what stands out is that the new studies are more contradictory in their findings; they lack evidence on this intervention in 50% of the results. A possible explanation for this discrepancy maybe based on the sample makeup of the studies: the studies are not clear on the criteria for subject inclusion and exclusion and the extent of MPA experienced, especially because every individual, without exception, was recruited from music learning/education centres and not in psychiatric and mental health specialised services. It is assumed that the response of symptomatic subjects to the interventions may differ from that of individuals who present ‘normal’ levels of MPA, which is considered common in the music profession. Two other points that may also explain this divergence is the technique utilised for each study, as well as the diversity in the number of sessions33. Ryan C, Andrews N. An investigation into the choral singer’s experience of music performance anxiety. J Res Music Educ. 2009;57(2):108-26.

4. Taborsky C. Musical performance anxiety: a review of literature. Update: Appl Res Music Educ. 2007;26:15-25.

5. Yondem ZD. Performance anxiety, dysfunctional attitudes and gender in university music students. J Soc Behav Pers. 2007;35(10):1415-26.

6. Kenny DT. The psychology of music performance anxiety. Oxford: Oxford University Press; 2011.

7. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208.

8. Brugues AO. Music performance anxiety – part 2. A review of treatment options. Med Probl Perform Art. 2011;26(3):164-71.

9. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 2009;6(7):e1000097.

10. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. The Cochrane Collaboration. 2011. Available at: <http://www.cochrane.org/handbook>. Accessed on: Jul 31. 2015.
http://www.cochrane.org/handbook...

11. Osborne MS, Kenny DT, Cooksey J. Impact of a cognitive-behavioural treatment program on music performance anxiety in secondary school music students: A pilot study. Music Sci Special issue. 2007;11(2):53-84.

12. Bien Aime JK. Managing performance anxiety in music students: using a solution focused approach. (Doctoral Dissertation). Nova Southeastern University, USA; 2011.

13. Clark T, Williamon A. Evaluation of mental skills training program for musicians. J Appl Sport Psychol. 2011;23(3):342-59.

14. Errico AS. The effects of a researcher-designed intervention on elementary students music performance anxiety levels. (Doctoral Dissertation); 2012.

15. Hoffman SL, Hanrahan J. Mental Skills for Musicians: Managing Music Performance Anxiety and Enhancing Performance. Sport Exerc Perform Psychol. 2012;1(1):17-28.

16. Braden AM, Osborne MS, Wilson SJ. Psychological intervention reduces self-reported performance anxiety in high school music students. Front Psychol. 2015;6:195.

17. Khalsa SB, Cope S. Effects of yoga lifestyle intervention on performance-related characteristics of musicians: a preliminary study. Med Sci Monit. 2006;12(8):CR325-31.-1818. Khalsa SB, Shorter SM, Cope S, Wyshak G, Sklar E. Yoga ameliorates performance anxiety and mood disturbance in young professional musicians. Appl Psychophysiol Biofeedback. 2009;34(4):279-89..

The use of virtual reality exposure for treating MPA has resulted in positive outcome tendencies, including reduced MPA, an improvement in self-confidence and decreases in discomfort and heart rate, although only one experimental study with inter-group design has been undertaken with this type of intervention. Considering the fact that virtual reality offers a safe and non-evaluative environment for the confrontation, training and management of anxious experiences, its use for this specific group may, in fact, be promising, especially because it involves habituation and desensitisation processes. Previous studies3737. Meyerbroker K, Emmelkamp PMG. Virtual reality exposure therapy in anxiety disorders: a systematic review of process and outcome studies. Depress Anxiety. 2010;27(10):933-44.,4242. Pinheiro TCM. Realidade virtual aplicada ao tratamento da ansiedade social. Lisbon, Portugal: Universidade de Lisboa, Master’s Thesis; 2012.also indicate positive results with the use of this intervention modality for other phobic-anxious disorders. Therefore, virtual reality is considered an intervention modality which requires studies with a greater methodological refinement and a larger sampling number so that its effectiveness may be proven.

Regarding the use of yoga, its relative efficacy for emotional symptoms has been studied in other contexts involving clinical aspects such as on cancer patients4343. McCall M, Thorne S, Ward A, Heneghan A. Yoga in adult cancer: an exploratory, qualitative analysis of the patient experience. BMC Complement Altern Med. 2015;5:245., with chronic obstructive pulmonary disease4444. Liu XC, Pan L, Hu Q, Dong WP, Yan JH, Dong L. Effects of yoga training in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. J Thorac Dis. 2014;6(6):795-802., and on cases of arterial hypertension4545. Tolbanos Roche L, Mas Hesse B. Application of an integrative yoga therapy programme in cases of essential arterial hypertension in public healthcare. Complement Ther Clin Pract. 2014;20(4):285-90.. It has also been used in studies involving psychiatric aspects, such as post-partum depression4646. Buttner MM, Brock RL, O’Hara MW, Stuart S. Efficacy of yoga for depressed postpartum women: A randomized controlled trial. Complement Ther Clin Pract. 2015 May;21(2):94-100.and anxiety disorders4747. Vorkapic CF, Rangé B. Os benefícios do yoga nos transtornos de ansiedade. Rev Bras Ter Cogn. 2011;7(1):50-4.. The results of these studies are promising and suggest positive effects on mental and physical awareness and well-being4343. McCall M, Thorne S, Ward A, Heneghan A. Yoga in adult cancer: an exploratory, qualitative analysis of the patient experience. BMC Complement Altern Med. 2015;5:245.as well as increases in lung capacity4444. Liu XC, Pan L, Hu Q, Dong WP, Yan JH, Dong L. Effects of yoga training in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. J Thorac Dis. 2014;6(6):795-802. significant decreases in systolic and diastolic blood pressure in hypertensive patients, decreases in depression and anxiety-related symptoms4646. Buttner MM, Brock RL, O’Hara MW, Stuart S. Efficacy of yoga for depressed postpartum women: A randomized controlled trial. Complement Ther Clin Pract. 2015 May;21(2):94-100.and decreases in anxiety levels4747. Vorkapic CF, Rangé B. Os benefícios do yoga nos transtornos de ansiedade. Rev Bras Ter Cogn. 2011;7(1):50-4.. Despite the aforementioned methodological limitations, the results on MPA management are favourable. It is possible that aspects such as breathing training and meditation techniques are related to the effects observed on the anxiety symptoms, which deserve more refined investigation.

Regarding the findings on meditation, the results tend to reflect a decrease in MPA but are still quite weak and limited. Similar to yoga, meditation, which is often part of the yoga intervention, has been gaining ground in the field of mental health. This is especially true for mindfulness meditation4848. Grossman P, Niemann L, Schmidt S, Walach H. Mindfulness-based stress reduction and health benefits. A meta-analysis. J Psychosom Res. 2004;57(1):35-43.. For example, this intervention has had positive results in ruminations, which are repetitive thoughts on negative emotional experiences and worries in patients with anxiety and depression4949. Desrosiers A, Vine V, Klemanski DH, Nolen-Hoeksema S. Mindfulness and emotion regulation in depression and anxiety: common and distinct mechanisms of action. Depress Anxiety. 2013;30(7):654-61.. Positive results were also found regarding levels of anxiety and depression among cancer patients5050. Zhang MF, Wen YS, Liu WY, Peng LF, Wu XD, Liu QW. Effectiveness of Mindfulness-based Therapy for Reducing Anxiety and Depression in Patients With Cancer: A Meta-analysis. Medicine (Baltimore). 2015;94(45):e0897-0..

Meanwhile, the two studies that assessed the effectiveness of music therapy showed that this intervention modality may lead to decreases in MPA and stress symptoms, but these results still lack new studies with a greater methodological refinement. It is believed that the effectiveness of this intervention modality is associated with the techniques used, which include breathing exercises, improvisation and relaxation, as well as musical stimuli which may induce physical and emotional changes5151. Maratos A, Gold C, Wang X, Crawford M. Music therapy for depression (Review). The Cochrane Collaboration. 2010; Published by John Wiley & Sons, Ltd.. The effects of music therapy for the reduction of anxiety and depression symptoms are also being investigated in individuals with other medical conditions, such as Alzheimer’s5252. Guétin S, Portel F, Picot MC, Pommié C, Messaoudi M, Djabelkir L, et al. Effect of music therapy on anxiety and depression in patients with Alzheimer’s type dementia: randomised, controlled study. Dement Geriatr Cogn Disord. 2009;28(1):36-46. and terminal illnesses5353. Horne-Thompson A, Grocke D. The effect of music therapy on anxiety in patients who are terminally ill. J Palliat Med. 2008;11(4):582-90..

Studies on biofeedback have shown that this technique is being tested as a treatment for other psychiatric conditions, such as anxiety disorders, depression, eating disorders and schizophrenia5454. Schoenberg PLA, David AS. Biofeedback for psychiatric disorders: a systematic review. Appl Psychophysiol Biofeedback. 2014;39(2):109-35.. This is a method in which instrumentals are used with a focus on the processes of muscle relaxation, breathing techniques, awareness techniques and cognitive aspects, all of which result in easing the body’s self-regulatory process5555. Cutshall SM, Wentworth LJ, Wahner-Roedler DL, Vincent A, Schmidt JE, Loehrer LL, et al. Evaluation of a biofeedback-assisted meditation program as a stress management tool for hospital nurses: a pilot study. Explore (NY). 2011;7(2):110-2.. Such aspects of biofeedback may be related to the alterations observed in the different physiological parameters analysed in the studies2121. Thurber MR. Effects of heart-rate variability biofeedback training and emotional regulation on music performance anxiety in university students. (Doctoral Dissertation); 2006.,2222. Silvana M, Pop-Jordanova N, Georgiev D. Simultaneous EEG and EMG biofeedback for peak performance in musicians. Prilozi. 2008;29(1):239-52.. However, the findings are still quite speculative and do not allow for greater conclusions.

It has been observed that studies involving the Alexander technique continue to be conducted as of late; however, they have been focused on the outcome variables associated with musculoskeletal conditions because the technique aims to release muscular tension and to re-educate unbeneficial movement patterns5656. Klein SD, Bayard C, Wolf U. The Alexander Technique and musicians: a systematic review of controlled trials. BMC Complement Altern Med. 2014;14:414.. Despite signalling evidence of effectiveness for treating MPA, the study analysed herein presents important limitations as it has not been analysed statistically.

Finally, it is worth noting that, regardless of the intervention modality utilised, studies involving children and adolescents are necessary since the number of studies for this age group are quite limited. This fact reflects a well-known bias in the studies on social and performance anxiety, which is linked to the absence of early attention, diagnosis and treatment of the symptoms because they are considered common or of little relevance5757. Osório FL, Crippa JAS, Loureiro SR. Instrumentos de avaliação do transtorno de ansiedade social. Rev Bras Psiquiatr. 2005;32(2):73-83..

This perception is stronger in the musical contexts experiencing apprehension and anxiety when facing performances is considered a part of a musician’s routine. This prevents the recognition of its seriousness and the damages associated with MPA. Thus, diagnosis and, more importantly, interventions for musicians at early ages can prevent them from starting a career in music with the disadvantage brought by managing the symptoms of a clinical condition.

Few studies are based on professional musicians, perhaps due to the difficulty involved in recruiting them for experimental studies. Nonetheless, it is believed that this more select group (relative to music students) deserves special and specific attention, as many of them end up creating their own coping strategies, which often include the indiscriminate use of drugs with no medical supervision5858. Kenny D, Driscoll T, Ackermann B. Psychological well-being in professional orchestral musicians in Australia: a descriptive population study. Psychol Music. 2014;42(2):210-32..

Conclusions

Research on the treatment and intervention of MPA has been a focus for researchers in the last decade; however, a limited number of studies have been performed outside the medical/health care fields. The number of interventions and outcome variables analysed is extensive, and the positive results are notably centred around a decrease in states of anxiety. Among the interventions analysed, CBT still offers greater evidence of effectiveness. However, due to the many methodological weaknesses and the limited number of studies on a single intervention and outcome, the results require careful interpretation and do not allow for conclusions regarding intervention efficacy.

These aspects have been pointed77. Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208. and are still an important limitation for the field and support her statements that this body of knowledge is still inconsistent, inconclusive and methodologically fragile.

References

  • 1
    American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition, Washington DC, London – England 2013.
  • 2
    Papageorgi I, Hallam S, Welch GF. A conceptual framework for understanding musical performance anxiety. Res Stud Music Educ. 2007;28(1):83-107.
  • 3
    Ryan C, Andrews N. An investigation into the choral singer’s experience of music performance anxiety. J Res Music Educ. 2009;57(2):108-26.
  • 4
    Taborsky C. Musical performance anxiety: a review of literature. Update: Appl Res Music Educ. 2007;26:15-25.
  • 5
    Yondem ZD. Performance anxiety, dysfunctional attitudes and gender in university music students. J Soc Behav Pers. 2007;35(10):1415-26.
  • 6
    Kenny DT. The psychology of music performance anxiety. Oxford: Oxford University Press; 2011.
  • 7
    Kenny D. A systematic review of treatments for music performance anxiety. Anxiety Stress Coping. 2005;18(3):183-208.
  • 8
    Brugues AO. Music performance anxiety – part 2. A review of treatment options. Med Probl Perform Art. 2011;26(3):164-71.
  • 9
    Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 2009;6(7):e1000097.
  • 10
    Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. The Cochrane Collaboration. 2011. Available at: <http://www.cochrane.org/handbook>. Accessed on: Jul 31. 2015.
    » http://www.cochrane.org/handbook
  • 11
    Osborne MS, Kenny DT, Cooksey J. Impact of a cognitive-behavioural treatment program on music performance anxiety in secondary school music students: A pilot study. Music Sci Special issue. 2007;11(2):53-84.
  • 12
    Bien Aime JK. Managing performance anxiety in music students: using a solution focused approach. (Doctoral Dissertation). Nova Southeastern University, USA; 2011.
  • 13
    Clark T, Williamon A. Evaluation of mental skills training program for musicians. J Appl Sport Psychol. 2011;23(3):342-59.
  • 14
    Errico AS. The effects of a researcher-designed intervention on elementary students music performance anxiety levels. (Doctoral Dissertation); 2012.
  • 15
    Hoffman SL, Hanrahan J. Mental Skills for Musicians: Managing Music Performance Anxiety and Enhancing Performance. Sport Exerc Perform Psychol. 2012;1(1):17-28.
  • 16
    Braden AM, Osborne MS, Wilson SJ. Psychological intervention reduces self-reported performance anxiety in high school music students. Front Psychol. 2015;6:195.
  • 17
    Khalsa SB, Cope S. Effects of yoga lifestyle intervention on performance-related characteristics of musicians: a preliminary study. Med Sci Monit. 2006;12(8):CR325-31.
  • 18
    Khalsa SB, Shorter SM, Cope S, Wyshak G, Sklar E. Yoga ameliorates performance anxiety and mood disturbance in young professional musicians. Appl Psychophysiol Biofeedback. 2009;34(4):279-89.
  • 19
    Stern JR, Khalsa SB, Hoffman SG. A yoga intervention for music performance anxiety in conservatory students. Med Prob Perform Art. 2012;27(3):123-8.
  • 20
    Khalsa SB, Butzer B, Shorter SM, Reinhardt KM, Cope S. Yoga reduces performance anxiety in adolescent musicians. Altern Ther Health Med. 2013;19(2):34-45.
  • 21
    Thurber MR. Effects of heart-rate variability biofeedback training and emotional regulation on music performance anxiety in university students. (Doctoral Dissertation); 2006.
  • 22
    Silvana M, Pop-Jordanova N, Georgiev D. Simultaneous EEG and EMG biofeedback for peak performance in musicians. Prilozi. 2008;29(1):239-52.
  • 23
    Wells R, Outhred T, Healthers JA, Quintana DS, Kemp AH. Matter over mind: a randomized-controlled trial of single-session biofeedback training on performance anxiety and heart rate variability in musicians. PLoS One. 2012;7(10):e46597.
  • 24
    Chang JC, Midlarsky E, Lin P. The effects of meditation on music performance anxiety. Med Probl Perform Art. 2003;18(3):126-30.
  • 25
    Lin P, Chang J, Zemon V, Midlarsky E. Silent illumination: A study on Chan (Zen) meditation, anxiety, and musical performance quality. Psychol Music. 2008;36(2):139-55.
  • 26
    Su YH, Luh JJ, Chen HI, Lin CC, Liao MJ, Chen HS. Effects of using relaxation breathing training to reduce music performance anxiety in 3rd to 6th graders. Med Probl Perform Art. 2010;25(2):82-6.
  • 27
    Sousa CM, Goncalves M, Machado F, Efferth T, Greten T, Froeschen P, et al. Effects of qigong on performance-related anxiety and physiological stress functions in transverse flute music schoolchildren: a feasibility study. Zhong Xi Yi Jie He Xue Bao. 2012;10(8):858-65.
  • 28
    Orman EK. Effect of virtual reality graded exposure on heart rate self-reported anxiety. J Res Music Educ. 2003;51(4):302-15.
  • 29
    Bissonnette J, Dubé F, Provencher MD, Sala MTM. The effect of virtual training on music performance anxiety. International Symposium on Performance Science 2011 [PMID: 26395619].
  • 30
    Conklin NM. Musical performance anxiety in virtual performances: a comparison of recorded and live performance contexts. (Doctoral Dissertation). University of Oklahoma, USA, 2011.
  • 31
    Kim Y. Combined treatment of improvisation and desensitization to alleviate music performance anxiety in female college pianists: A pilot study. Med Probl Perform Art. 2005;20(1):17-24.
  • 32
    Kim Y. The effect of improvisation-assisted desensitization, and music-assisted progressive muscle relaxation and imagery on reducing pianists’ music performance anxiety. J Music Ther. 2008;45(2):165-91.
  • 33
    Hoberg A. Reducing performance anxiety in woodwind playing through the application of the Alexander Technique principles. Pretoria, South Africa: University of Pretoria, Department of Music; Master’s Thesis; 2008.
  • 34
    Barbar AE, Souza Crippa JA de, Lima Osório F de. Performance anxiety in Brazilian musicians: prevalence and association with psychopathology indicators. J Affect Disord. 2014;152-154:381-6.
  • 35
    McGinnis AM, Milling AL. Psychological treatment of musical performance anxiety: current status and future directions. Psychother Theor Res Pract Train. 2005;42(3):357-73.
  • 36
    Otte C. Cognitive behavioral therapy in anxiety disorders: current state of the evidence. Dialogues Clin Neurosci. 2011;13(4):413-21.
  • 37
    Meyerbroker K, Emmelkamp PMG. Virtual reality exposure therapy in anxiety disorders: a systematic review of process and outcome studies. Depress Anxiety. 2010;27(10):933-44.
  • 38
    Knapp P, Beck AT. Fundamentos, modelos conceituais, aplicações e pesquisa da terapia cognitiva. Rev Bras Psiquiatr. 2008;30(Supl II):S54-64.
  • 39
    Beck AT, Emery G, Greenber RL. Anxiety disorders and phobia: a cognitive perspective. New York: Basic Books; 1985.
  • 40
    Ito LM, Roso MC, Tiwari S, Kendall PC, Asbahr FR. Terapia cognitivo-comportamental da fobia social. Rev Bras Psiquiatr. 2008;30(Supl II):S96-101.
  • 41
    Hofmann SG, Smits, JAJ. Cognitive-Behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry. 2008;69(4):621-32.
  • 42
    Pinheiro TCM. Realidade virtual aplicada ao tratamento da ansiedade social. Lisbon, Portugal: Universidade de Lisboa, Master’s Thesis; 2012.
  • 43
    McCall M, Thorne S, Ward A, Heneghan A. Yoga in adult cancer: an exploratory, qualitative analysis of the patient experience. BMC Complement Altern Med. 2015;5:245.
  • 44
    Liu XC, Pan L, Hu Q, Dong WP, Yan JH, Dong L. Effects of yoga training in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. J Thorac Dis. 2014;6(6):795-802.
  • 45
    Tolbanos Roche L, Mas Hesse B. Application of an integrative yoga therapy programme in cases of essential arterial hypertension in public healthcare. Complement Ther Clin Pract. 2014;20(4):285-90.
  • 46
    Buttner MM, Brock RL, O’Hara MW, Stuart S. Efficacy of yoga for depressed postpartum women: A randomized controlled trial. Complement Ther Clin Pract. 2015 May;21(2):94-100.
  • 47
    Vorkapic CF, Rangé B. Os benefícios do yoga nos transtornos de ansiedade. Rev Bras Ter Cogn. 2011;7(1):50-4.
  • 48
    Grossman P, Niemann L, Schmidt S, Walach H. Mindfulness-based stress reduction and health benefits. A meta-analysis. J Psychosom Res. 2004;57(1):35-43.
  • 49
    Desrosiers A, Vine V, Klemanski DH, Nolen-Hoeksema S. Mindfulness and emotion regulation in depression and anxiety: common and distinct mechanisms of action. Depress Anxiety. 2013;30(7):654-61.
  • 50
    Zhang MF, Wen YS, Liu WY, Peng LF, Wu XD, Liu QW. Effectiveness of Mindfulness-based Therapy for Reducing Anxiety and Depression in Patients With Cancer: A Meta-analysis. Medicine (Baltimore). 2015;94(45):e0897-0.
  • 51
    Maratos A, Gold C, Wang X, Crawford M. Music therapy for depression (Review). The Cochrane Collaboration. 2010; Published by John Wiley & Sons, Ltd.
  • 52
    Guétin S, Portel F, Picot MC, Pommié C, Messaoudi M, Djabelkir L, et al. Effect of music therapy on anxiety and depression in patients with Alzheimer’s type dementia: randomised, controlled study. Dement Geriatr Cogn Disord. 2009;28(1):36-46.
  • 53
    Horne-Thompson A, Grocke D. The effect of music therapy on anxiety in patients who are terminally ill. J Palliat Med. 2008;11(4):582-90.
  • 54
    Schoenberg PLA, David AS. Biofeedback for psychiatric disorders: a systematic review. Appl Psychophysiol Biofeedback. 2014;39(2):109-35.
  • 55
    Cutshall SM, Wentworth LJ, Wahner-Roedler DL, Vincent A, Schmidt JE, Loehrer LL, et al. Evaluation of a biofeedback-assisted meditation program as a stress management tool for hospital nurses: a pilot study. Explore (NY). 2011;7(2):110-2.
  • 56
    Klein SD, Bayard C, Wolf U. The Alexander Technique and musicians: a systematic review of controlled trials. BMC Complement Altern Med. 2014;14:414.
  • 57
    Osório FL, Crippa JAS, Loureiro SR. Instrumentos de avaliação do transtorno de ansiedade social. Rev Bras Psiquiatr. 2005;32(2):73-83.
  • 58
    Kenny D, Driscoll T, Ackermann B. Psychological well-being in professional orchestral musicians in Australia: a descriptive population study. Psychol Music. 2014;42(2):210-32.
  • Funding
    The São Paulo Research Foundation, Foundation for Research Support of the State of São Paulo (Fapesp) (Process No. 2015/ 00097-0).

Publication Dates

  • Publication in this collection
    Sep-Oct 2016

History

  • Received
    30 Aug 2016
  • Accepted
    1 Oct 2016
Creative Common - by 4.0
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Faculdade de Medicina da Universidade de São Paulo Rua Ovídio Pires de Campos, 785 , 05403-010 São Paulo SP Brasil, Tel./Fax: +55 11 2661-8011 - São Paulo - SP - Brazil
E-mail: archives@usp.br
Acompanhe os números deste periódico no seu leitor de RSS