Altshuler et al. (2005) 11 Lu X, Zhong Y, Ma Z. Structural imaging biomarkers for bipolar disorder: Meta-analyses of whole-brain voxel-based morphometry studies. Depress Anxiety. 2019;36(4):353-364. doi: 10.1002/da.22866 https://doi.org/10.1002/da.22866...
|
Task fMRI |
– |
11 |
13 |
36±7.6 |
36% |
DSM-IV BDI |
Mixed |
Manic |
Go-NoGo task |
HC >BD |
3 |
p < 0.0001, uncorrected |
NR |
Chen et al. (2006) 22 Alústiza I, Radua J, Pla M, Martin R, Ortuño F. Meta-analysis of functional magnetic resonance imaging studies of timing and cognitive control in schizophrenia and bipolar disorder: Evidence of a primary time deficit. Schizophrenia research 2017;188:21-32. doi: 10.1016/j.schres.2017.01.039 https://doi.org/10.1016/j.schres.2017.01...
|
Task fMRI |
– |
8 |
8 |
39± 13.44 |
100% |
DSM-IV BDI |
Medicated |
Manic, Depressed |
Implicit Facial Affect Recognition |
HC >BD |
8 |
p < 0.005 uncorrected |
NR |
Roth et al. (2006) 33 Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2009;6(7):e1000097. doi: 10.1371/journal.pmed.1000097 https://doi.org/10.1371/journal.pmed.100...
|
Task fMRI |
– |
11 |
11 |
37.7±14.4 |
NR |
DSM-IV BDI |
Medicated |
Mixed |
a counting Stroop task |
HC >BD |
7 |
p < 0.005 uncorrected |
NR |
Lagopoulos et al. (2007) 44 Laird AR, Robinson JL, McMillan KM, Tordesillas-Gutierrez D, Moran ST, Gonzales SM, Ray KL, Franklin C, Glahn DC, Fox PT, Lancaster JL. Comparison of the disparity between Talairach and MNI coordinates in functional neuroimaging data: validation of the Lancaster transform. Neuroimage. 2010;51(2):677-83. doi: 10.1016/j.neuroimage.2010.02.048 https://doi.org/10.1016/j.neuroimage.201...
|
Task fMRI |
– |
10 |
10 |
32.4±10.8 |
NR |
DSM-IV BDI |
Medicated |
euthymic |
working memory task |
HC >BD |
2 |
FDR p < 0.05 |
NR |
Altshuler et al. (2008) 55 Lancaster JL, Tordesillas-Gutierrez D, Martinez M, Salinas F, Evans A, Zilles K, Mazziotta JC, Fox PT. Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template. Hum Brain Mapp. 2007;28(11):1194-205. doi: 10.1002/hbm.20345 https://doi.org/10.1002/hbm.20345...
|
Task fMRI |
– |
11 |
17 |
32 ± 7.3 |
NR |
DSM-IV BDI |
Mixed |
depressive |
face-matching paradigm |
HC > BD |
3 |
p < 0.01 uncorrected |
NR |
BD > HC |
1 |
McIntosh et al. (2008) 66 Turkeltaub PE, Eickhoff SB, Laird AR, Fox M, Wiener M, Fox P. Minimizing within-experiment and within-group effects in Activation Likelihood Estimation meta-analyses. Hum Brain Mapp. 2012;33(1):1-13. doi: 10.1002/hbm.21186 https://doi.org/10.1002/hbm.21186...
|
Task fMRI |
– |
42 |
37 |
39.3 ± 10.8 |
55.3% |
DSM-IV BD |
NR |
NR |
Hayling Sentence Completion Test |
HC > BD |
1 |
p < 0.005 uncorrected |
NR |
Kaladjian et al. (2009) 77 Achalia RM, Jacob A, Achalia G, Sable A, Venkatasubramanian G, Rao NP. Investigating spontaneous brain activity in bipolar disorder: A resting-state functional magnetic resonance imaging study. Indian J Psychiatry 2019;61(6)630-634. doi: 10.4103/psychiatry.IndianJPsychiatry_391_19 https://doi.org/10.4103/psychiatry.India...
|
Task fMRI |
– |
20 |
20 |
37.9 ± 11.4 |
50% |
DSM-IV BDI |
Unmedicated |
Euthymic |
a Go–NoGo task |
HC >BD |
3 |
p < 0.05 FWE-corrected |
NR |
Linke et al. (2012) 88 Gao W, Jiao Q, Lu S, Zhong Y, Qi R, Lu D, Xiao Q, Yang F, Lu G, Su L. Alterations of regional homogeneity in pediatric bipolar depression: a resting-state fMRI study. BMC Psychiatry 2014;14:222. doi: 10.1186/s12888-014-0222-y. https://doi.org/10.1186/s12888-014-0222-...
|
Task fMRI |
– |
19 |
22 |
45 ±10 |
42% |
DSM-IV BDI |
Unmedicated |
Euthymic |
a probabilistic reversal learning task |
HC >BD |
8 |
p < 0.05 FWE-corrected |
NR |
Liu et al. (2012) 99 Liang MJ, Zhou Q, Yang KR, Yang XL, Fang J, Chen WL, Huang Z. Identify changes of brain regional homogeneity in bipolar disorder and unipolar depression using resting-state FMRI. PLoS One. 2013;8(12):e79999. doi: 10.1371/journal.pone.0079999 https://doi.org/10.1371/journal.pone.007...
|
Rs-fMRI |
ALFF |
26 |
26 |
32.35 ±11.31 |
34.6% |
DSM-IV BD |
Medicated |
depressive |
– |
HC > BD |
4 |
p < 0.01 uncorrected |
NR |
BD > HC |
10 |
Townsen d et al. (2012) 1010 Liu CH, Li F, Li SF, Wang YJ, Tie CL, Wu HY, Zhou Z, Zhang D, Dong J, Yang Z, Wang CY. Abnormal baseline brain activity in bipolar depression: a resting state functional magnetic resonance imaging study. Psychiatry Res. 2012;203(2-3):175-9. doi: 10.1016/j.pscychresns.2012.02.007 https://doi.org/10.1016/j.pscychresns.20...
|
Task fMRI |
– |
32 |
30 |
37 ± 13 |
65.6% |
DSM-IV BDI |
Unmedicated |
euthymic |
a Go–NoGo task |
HC > BD |
17 |
|
|
Vizueta et al. (2012) 1111 Lu D, Jiao Q, Zhong Y, Gao W, Xiao Q, Liu X, Lin X, Cheng W, Luo L, Xu C, Lu G, Su L. Altered baseline brain activity in children with bipolar disorder during mania state: a resting-state study. Neuropsychiatr Dis Treat. 2014;10:317-23. doi: 10.2147/NDT.S54663 https://doi.org/10.2147/NDT.S54663...
|
Task fMRI |
– |
21 |
21 |
NR |
52.4% |
DSM-IV BDII |
Mixed |
depressive |
an emotional face-matching task |
HC > BD |
5 |
p < 0.005 uncorrected |
NR |
BD > HC |
7 |
Liang et al. (2013) 1212 Qiu M, Zhang H, Mellor D, Shi J, Wu C, Huang Y, Zhang J, Shen T, Peng D. Aberrant Neural Activity in Patients With Bipolar Depressive Disorder Distinguishing to the Unipolar Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study. Front Psychiatry. 2018;9:238. doi: 10.3389/fpsyt.2018.00238 https://doi.org/10.3389/fpsyt.2018.00238...
|
Rs-fMRI |
ReHo |
17 |
16 |
34.47 ± 9.77 |
52.9% |
DSM-IV BD |
Unmedicated |
depressive |
– |
HC > BD |
13 |
p < 0.05 uncorrected |
NR |
BD > HC |
9 |
Sagar et al. (2013) 1313 Qiu S, Chen F, Chen G, Jia Y, Gong J, Luo X, Zhong S, Zhao L, Lai S, Qi Z, Huang L, Wang Y. Abnormal resting-state regional homogeneity in unmedicated bipolar II disorder. J Affect Disord. 2019;256:604-610. doi: 10.1016/j.jad.2019.06.037 https://doi.org/10.1016/j.jad.2019.06.03...
|
Task fMRI |
– |
23 |
18 |
26.65 ± 6.65 |
NR |
DSM-IV BDI |
Medicated |
NR |
a backward-masked affect paradigm |
HC > BD |
12 |
p < 0.05 uncorrected |
NR |
BD > HC |
30 |
Xiao et al. (2013) 1414 Skatun KC, Kaufmann T, Tonnesen S, Biele G, Melle I, Agartz I, Alnaes D, Andreassen OA, Westlye LT. Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders. J Psychiatry Neurosci. 2016;41(5):331-41. doi: 10.1503/jpn.150159 https://doi.org/10.1503/jpn.150159...
|
Rs-fMRI |
ReHo |
15 |
15 |
15.0 ± 1.7 |
40% |
DSM-IV Pediatric BD |
Medicated |
Manic |
– |
HC > BD |
10 |
p < 0.05 FWE-corrected |
NR |
BD > HC |
5 |
Gao et al. (2013) 1515 Wang Y, Zhong S, Chen G, Liu T, Zhao L, Sun Y, Jia Y, Huang L. Altered cerebellar functional connectivity in remitted bipolar disorder: A resting-state functional magnetic resonance imaging study. Aust N Z J Psychiatry. 2018;52(10):962-971. doi: 10.1177/0004867417745996 https://doi.org/10.1177/0004867417745996...
|
Rs-fMRI |
ReHo |
17 |
18 |
14.4 ± 1.77 |
41.2% |
DSM-IV Pediatric BD |
Mixed |
depressive |
|
HC > BD |
6 |
p < 0.05 uncorrected |
NR |
Lu et al. (2014) 1616 Wang Y, Zhong S, Jia Y, Zhou Z, Wang B, Pan J, Huang L. Interhemispheric resting state functional connectivity abnormalities in unipolar depression and bipolar depression. Bipolar Disord. 2015;17(5):486-95. doi: 10.1111/bdi.12315 https://doi.org/10.1111/bdi.12315...
|
Rs-fMRI |
ALFF |
18 |
18 |
15.1 ± 1.81 |
33.3% |
DSM-IV Pediatric BD |
Medicated |
Manic |
– |
HC > BD |
4 |
p < 0.001 uncorrected |
NR |
BD > HC |
3 |
McKenna et al. (2014) 1717 Xiao Q, Zhong Y, Lu D, Gao W, Jiao Q, Lu G, Su L. Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study. PLoS One. 2013;8(3):e57978. doi: 10.1371/journal.pone.0057978 https://doi.org/10.1371/journal.pone.005...
|
Task fMRI |
– |
23 |
23 |
45.31 ± 9.45 |
34.9% |
DSM-IV BD |
Medicated |
euthymic |
a delayed match-to-sampleWM paradigm |
HC > BD |
5 |
p < 0.01 uncorrected |
NR |
BD > HC |
3 |
Rey et al. (2014) 1818 Yang Y, Liu S, Jiang X, Yu H, Ding S, Lu Y, Li W, Zhang H, Liu B, Cui Y, Fan L, Jiang T, Lv L. Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder. Front Psychiatry. 2019;10:52. doi: 10.3389/fpsyt.2019.00052 https://doi.org/10.3389/fpsyt.2019.00052...
|
Task fMRI |
– |
12 |
12 |
42.6 ± 11.4 |
66.7% |
DSM-IV BD |
Medicated |
Depressive, euthymic, hypomania |
|
HC > Depressive BD |
2 |
p < 0.001 uncorrected |
NR |
HC > euthymic BD |
1 |
Favre et al. (2015) 1919 Yao X, Yin Z, Liu F, Wei S, Zhou Y, Jiang X, Wei Y, Xu K, Wang F, Tang Y. Shared and distinct regional homogeneity changes in bipolar and unipolar depression. Neurosci Lett. 2018;673:28-32. doi: 10.1016/j.neulet.2018.02.033 https://doi.org/10.1016/j.neulet.2018.02...
|
Task fMRI |
– |
14 |
13 |
44.07 ± 9.63 |
36% |
DSM-IV BD |
Mixed |
euthymic |
a word-face emotional Stroop task |
HC > BD |
4 |
p < 0.001 uncorrected |
NR |
Wang et al. (2015) 2020 Altshuler L, Bookheimer S, Townsend J, Proenza MA, Sabb F, Mintz J, Cohen MS. Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study. Bipolar disorders 2008;10(6):708-717. doi: 10.1111/j.1399-5618.2008.00617.x https://doi.org/10.1111/j.1399-5618.2008...
|
Rs-fMRI |
VMHC |
26 |
40 |
26.12 ± 10.30 |
57.7% |
DSM-IV BDII |
Unmedicated |
NR |
– |
HC > BD |
2 |
p < 0.05 uncorrected |
NR |
Skatun et al. (2016) 2121 Altshuler LL, Bookheimer SY, Townsend J, Proenza MA, Eisenberger N, Sabb F, Mintz J, Cohen, MS. Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biol psychiatry 2005;58(10):763-769. doi: 10.1016/j.biopsych.2005.09.012 https://doi.org/10.1016/j.biopsych.2005....
|
Rs-fMRI |
FC |
43 |
196 |
31.3 ± 11.3 |
43.2% |
DSM-IV BD |
Mixed |
NR |
– |
HC > BD |
6 |
p < 0.05 uncorrected |
NR |
King et al. (2018) 2222 Chen CH, Lennox B, Jacob R, Calder A, Lupson V, Bisbrown-Chippendale R, Suckling J, Bullmore E. Explicit and implicit facial affect recognition in manic and depressed States of bipolar disorder: a functional magnetic resonance imaging study. Biol Psychiatry 2006;59(1):31-9. doi: 10.1016/j.biopsych.2005.06.008 https://doi.org/10.1016/j.biopsych.2005....
|
Task fMRI |
– |
35 |
35 |
15 ± 2 |
|
DSM-IV Pediatric BDI |
Unmedicated |
euthymic |
a self-paced sequential bilateral finger-tapping task |
HC > BD |
4 |
FDR p < 0.05 |
NR |
Qiu et al. (2018) 2323 Favre P, Polosan M, Pichat C, Bougerol T, Baciu M. Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study. 2015;10(8):e0134961. doi: 10.1371/journal.pone.0134961. https://doi.org/10.1371/journal.pone.013...
|
Rs-fMRI |
fALFF |
28 |
27 |
31.79 ± 12.83 |
50% |
DSM-IV BD |
Mixed |
depressive |
– |
HC > BD |
2 |
p < 0.001 uncorrected |
age, gender and education level |
BD > HC |
1 |
Wang et al. (2018)2424 Kaladjian A, Jeanningros R, Azorin JM, Nazarian B, Roth M, Mazzola-Pomietto P. Reduced brain activation in euthymic bipolar patients during response inhibition: an event-related fMRI study. Psychiatry Res 2009;173(1):45-51. doi: 10.1016/j.pscychresns.2008.08.003. https://doi.org/10.1016/j.pscychresns.20...
|
Rs-fMRI |
FC |
25 |
25 |
28.55 ± 9.76 |
36% |
DSM-IV BDII |
NR |
NR |
– |
HC > BD |
2 |
p < 0.005 uncorrected |
age and educational level |
Yao et al. (2018) 2525 King JB, Anderson JS, Yurgelun-Todd DA, Subramaniam P, Ehrler MR, Lopez-Larson MP. Decreased anterior cingulate activation in a motor task in youths with bipolar disorder. J Child Psychol Psychiatry. 2018;59(8):900-907. doi: 10.1111/jcpp.12875 https://doi.org/10.1111/jcpp.12875...
|
Rs-fMRI |
ReHo |
55 |
113 |
27.02 ± 7.706 |
40% |
DSM-IV BDI |
Mixed |
depressive |
– |
HC > BD |
4 |
p < 0.005 uncorrected |
NR |
Achalia et al. (2019) 2626 Lagopoulos J, Ivanovski, B, Malhi GS. An event-related functional MRI study of working memory in euthymic bipolar disorder. J Psychiatry Neurosci. 2007;32(3):174-84.
|
Rs-fMRI |
ReHo |
20 |
20 |
24.60 ± 7.04 |
52% |
DSM-IV BDI |
Medicated |
euthymic |
– |
BD > HC |
7 |
p < 0.0001 uncorrected |
NR |
Qiu et al. (2019) 2727 Linke J, King AV, Rietschel M, Strohmaier J, Hennerici M, Gass A, Meyer-Lindenberg A, Wessa M. Increased medial orbitofrontal and amygdala activation: evidence for a systems-level endophenotype of bipolar I disorder. Am J Psychiatry. 2012;169(3):316-25. doi: 10.1176/appi.ajp.2011.11050711 https://doi.org/10.1176/appi.ajp.2011.11...
|
Rs-fMRI |
ReHo |
100 |
100 |
26.37 ± 8.89 |
55% |
DSM-IV BDII |
unmedicated |
depressive |
– |
HC > BD |
5 |
p < 0.05 uncorrected |
NR |
Yang et al. (2019) 2828 McIntosh AM, Whalley HC, McKirdy J, Hall J, Sussmann JE, Shankar P, Johnstone EC, Lawrie SM. Prefrontal function and activation in bipolar disorder and schizophrenia. Am J Psychiatry. 2008;165(3):378-84. doi: 10.1176/appi.ajp.2007.07020365 https://doi.org/10.1176/appi.ajp.2007.07...
|
Rs-fMRI |
fALFF |
41 |
93 |
32.98 ± 9.41 |
56% |
DSM-IV BD |
Mixed |
NR |
– |
HC > BD |
3 |
p < 0.001 uncorrected |
Age and sex |
BD > HC |
3 |