Osunkwo et al.2727 Osunkwo I, Ziegler TR, Alvarez J, McCracken C, Cherry K, Osunkwo CE, et al. High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study. Br J Haematol. 2012;159:211-5.
|
2 |
46 |
The results suggest the potential benefit of vitamin D supplementation in the reduction of the number of days with pain in sickle cell disease. |
Shams et al.2828 Shams T, Al Wadani H, El-Masry R, Zakaria O. Effect of prophylactic vitamin D on anesthetic outcome in children with sickle cell disease. J Anaesthesiol Clin Pharmacol. 2014;30:20-4.
|
2 |
58 |
Vitamin D administration was associated with lower postoperative analgesia requirement and postoperative complications. |
Jackson et al.1616 Jackson TC, Krauss MJ, DeBaun MR, Strunk RC, Arbeláez AM. Vitamin-D deficiency and comorbidities in children with sickle cell anemia. Pediatr Hematol Oncol. 2012;29:261-6.
|
6 |
139 |
Low levels of vitamin D were associated with lung function, but were not associated with painful crises and acute chest syndrome. |
Osunkwo et al.1717 Osunkwo I, Hodgman EI, Cherry K, Dampier C, Eckman J, Ziegler TR, et al. Vitamin D deficiency and chronic pain in sickle cell disease. Br J Haematol. 2011;153:529-40.
|
6 |
53 |
Patients with sickle-cell disease have a tendency to vitamin D deficiency, and research suggests an association between vitamin D deficiency and bone fragility. |
Garrido et al.1818 Garrido C, Cela E, Beléndez C, Mata C, Huerta J. Status of vitamin D in children with sickle cell disease living in Madrid, Spain. Eur J Pediatr. 2012;171:1793-98.
|
6 |
78 |
Vitamin D deficiency was prevalent in children with sickle-cell disease in Madrid. |
Van der Dijs et al.2222 Van der Dijs FP, van der Klis FR, Muskiet FD, Muskiet FA. Serum calcium and vitamin D status of patients with sickle cell disease in Curaçao. Ann Clin Biochem. 1997;34:170-2.
|
6 |
18 |
The vitamin D levels in patients with sickle-cell anemia in Curacao are appropriate. |
Chapelon, et al.1919 Chapelon E, Garabedian M, Brousse V, Souberbielle JC, Bresson JL, de Montalembert M. Osteopenia and vitamin D deficiency in children with sickle cell disease. Eur J Haematol. 2009;83:572-8.
|
6 |
53 |
A slight decrease in bone mineral density, unrelated to vitamin D deficiency, was found in children with sickle-cell disease, beginning at puberty and being more marked among females. |
Buison et al.99 Buison AM, Kawchak DA, Schall J, Ohene-Frempong K, Stallings VA, Zemel BS. Low vitamin D status in children with sickle cell disease. J Pediatr. 2004;145:622-7.
|
6 |
65 |
Low serum levels of vitamin D had a high prevalence in children with sickle-cell disease and were associated with seasonal variations and diet. |
Rovner et al.1010 Rovner AJ, Stallings VA, Kawchak DA, Schall JI, Ohene-Frempong K, Zemel BS. High risk of vitamin D deficiency in children with sickle cell disease. J Am Diet Assoc. 2008;108:1512-6.
|
6 |
150 |
The risk of individuals with sickle-cell disease to have vitamin D deficiency was 5.3 times higher than that of healthy subjects. |
Lal et al.2020 Lal A, Fung EB, Pakbaz Z, Hackney-Stephens E, Vichinsky EP. Bone mineral density in children with sickle cell anemia. Pediatr Blood Cancer. 2006;47:901-6.
|
6 |
25 |
Children with severe manifestations of sickle-cell disease have low bone density, as well as a diet poor in calcium and vitamin D. Vitamin D deficiency was higher in patients whose weight and/or height were below average. |
Ozen et al.2121 Özen S, Ünal S, Erçetin N, Taşdelen B. Frequency and risk factors of endocrine complications in Turkish children and adolescents with sickle cell anemia. Turk J Hematol. 2013;30:25-31.
|
6 |
50 |
The results suggest the potential benefit of vitamin D supplementation on reducing the number of days with pain in sickle-cell disease |