Frequency |
WNT |
16.3% |
11.0%1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
|
SHH |
34.7% |
28.0%1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
|
Non-WNT/non-SHH group |
49.0% |
61.0%1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
|
Gender (M:F) |
WNT |
0.6:1 |
1:11414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
3.2:1 |
1:11414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Non-WNT/non-SHH group |
2.4:1 |
2:11414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Age group |
WNT |
All 3-16 |
Mostly 3-161414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
Mostly 3-16 |
Mostly <3 or >161414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Non-WNT/non-SHH group |
Mostly 3-16 |
<3 and 3-161414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Histology |
WNT |
Mostly classic |
Mostly classic1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
Mostly desmoplastic |
Classic, desmoplastic, A/LC1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Non-WNT/non-SHH group |
Mostly classic |
Classic, A/LC1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Metastasis |
WNT |
25% |
Rare (9%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
23% |
Unusual (17-22%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Non-WNT/non-SHH group |
70% |
Very frequent (30-47%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Prognosis* |
WNT |
75% |
Better (>90%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
58.8% |
Intermediate (68-75%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Non-WNT/non-SHH group |
66.7% |
Worse (45-58%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|