Appleman et al.2020 Appleman SS, Kalkwarf HJ, Dwivedi A, Heubi JE. Bone deficits in parenteral nutrition-dependent infants and children with intestinal failure are attenuated when accounting for slower growth. J Pediatr Gastroenterol Nutr. 2013;57:124-30. https://doi.org/10.1097/MPG.0b013e318291fec5 https://doi.org/10.1097/MPG.0b013e318291...
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Median: 26 Min-Max (6–127) months |
Lumbar (15%), Total (12%), ↓ in IF than the control group |
Median: 18.5 Min-Max (4–103) months |
Not reported |
Demehri et al.1616 Demehri FR, Simha S, Stephens L, Harris MB, Arnold MA, Brown PI, et al. Pediatric intestinal failure: predictors of metabolic bone disease. J Pediatr Surg. 2015;50:958-62. https://doi.org/10.1016/j.jpedsurg.2015.03.018 https://doi.org/10.1016/j.jpedsurg.2015....
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≥6 years and diagnosed until 18 years |
Lumbar: Mean±SD: -1.36±1.47 First DXA Mean±SD: -1.36±1.18 Second DXA |
Mean±SD: 5.1±5.4 years |
Not reported |
Diamanti et al.1313 Diamanti A, Bizzarri C, Basso MS, Gambarara M, Cappa M, Daniele A, et al. How does long-term parenteral nutrition impact the bone mineral status of children with intestinal failure? J Bone Miner Metab. 2010;28:351-8. https://doi.org/10.1007/s00774-009-0140-0 https://doi.org/10.1007/s00774-009-0140-...
|
Mean±SD: (5.1±2.9) years |
Total Mean±SD: -2.5±1.2
|
Mean±SD: 32.4±28.8 months |
Not reported |
Khan et al.2424 Khan FA, Fisher JG, Bairdain S, Sparks EA, Zurakowski D, Modi BP, et al. Metabolic bone disease in pediatric intestinal failure patients: prevalence and risk factors. J Pediatr Surg. 2015;50:136-9. https://doi.org/10.1016/j.jpedsurg.2014.10.010 https://doi.org/10.1016/j.jpedsurg.2014....
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≥5 to 20 years |
DXA less or equal–2 Mean±SD: 1772.9±1453.7 DXA greater–2 Mean±SD: 1126.1±1194.3 p=0.09 ↓ 22 childrens (22/65)–40% |
Mean±SD: 44.2± 43.2 (unity) |
DXA less or equal – 2 Mean±SD: 2127.9±1921.9 DXA greater – 2 Mean±SD: 2187.2±1300.0 p=0.92 32 days |
Kvammen et al.2525 Kvammen JA, Thomassen RA, Kjeserud CN, Sæland C, Godang K, Bollerslev J, et al. Bone mineral density and vitamin D in paediatric intestinal failure patients receiving home parenteral nutrition. Clin Nutr ESPEN. 2020;39:234-41. https://doi.org/10.1016/j.clnesp.2020.06.006 https://doi.org/10.1016/j.clnesp.2020.06...
|
Mean±SD: 10.1±3.5 years |
Total median: -0.4 and Lumbar: -0.9 |
>6 months |
Not reported |
Louazon et al.2121 Louazon T, Poinsot P, Restier L, Belmalih A, Loras-Duclaux I, Marotte S, et al. A prospective case-control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT. Sci Rep. 2021;11:9151. https://doi.org/10.1038/s41598-021-88366-6 https://doi.org/10.1038/s41598-021-88366...
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Median: 16 Min-Max (9–19) years |
Spine total: Median (Min-Max) and BMC (g): 40 (14–66) and BMD (g/cm²): 0.8 (0.4–0.9) and Whole body: Median (Min-Max) BMC (g): 1198 (441–1832) and BMD (g/cm²): 0.81 (0.54–0.96) |
Median: 10.3 Min-Max (6.4–18.3) years |
Not reported |
Mutanen et al.2222 Mutanen A, Mäkitie O, Pakarinen MP. Risk of metabolic bone disease is increased both during and after weaning off parenteral nutrition in pediatric intestinal failure. Horm Res Paediatr. 2013;79:227-35. https://doi.org/10.1159/000350616 https://doi.org/10.1159/000350616...
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Mean: 9.9 Min-Max (0.2–27) years |
Lumbar: Mean: -2.1 Min-Max (-4.1–0.9) Femur: Mean: -0.9 Min-Max (-2.7–1.1) |
Mean: 41 Min-Max (0.7–250) months |
Lumbar: Mean: -1.2 Min-Max (-3.2–0.9). Femur: Mean: -0.8 Min-Max (-2.6–0.7) 9.0 years min-max (0.3–27) |
Nader et al.2323 Nader EA, Lambe C, Talbotec C, Acramel A, Pigneur B, Goulet O. Metabolic bone disease in children with intestinal failure is not associated with the level of parenteral nutrition dependency. Clin Nutr. 2021;40:1974-82. https://doi.org/10.1016/j.clnu.2020.09.014 https://doi.org/10.1016/j.clnu.2020.09.0...
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Mean±SD: 12.4±4.5 years Median: 12.2 years |
BMI mean±SD: -0.5±1.3 – Median: -0.4 BMI ≤-2 SD [n(%)]: 7 (18) |
Mean±SD: 12.4±4.4 years Median: 12.4 years |
Not reported |
Olieman et al.1414 Olieman JF, Penning C, Spoel M, Ijsselstijn H, van den Hoonaard TL, Escher JC, et al. Long-term impact of infantile short bowel syndrome on nutritional status and growth. Br J Nutr. 2012;107:1489-97. https://doi.org/10.1017/S0007114511004582 https://doi.org/10.1017/S000711451100458...
|
Mean±SD: 11.8±4.2) years |
Total: Mean±SD: -0.04±1.4 and Lumbar: Mean±SD: -0.47±1.2 – BMC: Mean±SD: -1.0±1.1 |
Median: 110 Min-Max (43–2345) days |
Not reported |
Pichler et al.1212 Pichler J, Chomtho S, Fewtrell M, Macdonald S, Hill SM. Growth and bone health in pediatric intestinal failure patients receiving long-term parenteral nutrition. Am J Clin Nutr. 2013;97:1260-9. https://doi.org/10.3945/ajcn.112.057935 https://doi.org/10.3945/ajcn.112.057935...
|
5 to 14 years |
Total: Mean±SD: -1.3±1 |
Median: 4.5 Min-Max (2–11.4) years |
Not reported |
Poinsot et al.99 Poinsot P, Geoffroy P, Braillon P, Denis A, Loras-Duclaux I, Marotte S, et al. Longitudinal bone mineralization assessment in children treated with long-term parenteral nutrition for severe intestinal failure. JPEN J Parenter Enteral Nutr. 2018;42:613-22. https://doi.org/10.1177/0148607117701399 https://doi.org/10.1177/0148607117701399...
|
Median 2.9 Min-Max (0.40–13.3) years |
TBMC Median: -1.9(-5.3 to 2.6) – first DXA TBMC: Median: -1.14(-2.25 to 1.84) – Last DXA |
Median: 2.7 Min-Max (0.1–12.7) years |
Not reported |