Passos et al., 20202525 Passos MM, Andrade AC, Villa AL, Fonseca R, Monteiro MS. Manipulated drugs for newborns. Rev Ped SOPERJ. 2020;20:37-43. https://doi.org/10.31365/issn.2595-1769.v20i2p37-43 https://doi.org/10.31365/issn.2595-1769....
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Retrospective descriptive study |
To describe the prescriptions of compounded medications for neonate patients and verify their pharmacotechnical preparation |
NICU: Spironolactone, Captopril, Furosemide, Hydrochlorothiazide, Propranolol |
Costa et al., 20181313 Costa HT, Costa TX, Martins RR, Oliveira AG. Use of off-label and unlicensed medicines in neonatal intensive care. PLoS One. 2018;13:e0204427. https://doi.org/10.1371/journal.pone.0204427 https://doi.org/10.1371/journal.pone.020...
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Prospective cohort study |
To evaluate the use of off-label and unlicensed medicines in a NICU of a maternity teaching hospital specialized in high-risk pregnancy |
NICU: Spironolactone, Furosemide, and Hydrochlorothiazide |
Britto et al., 20172626 Britto JF, Messias GC, Souza EP, Prado NM. Use of extemporaneous magistral preparations in pediatric patients of a public hospital. Saúde.com. 2017;13:797-805. https://doi.org/10.22481/rsc.v13i1.374 https://doi.org/10.22481/rsc.v13i1.374...
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Descriptive study |
To describe the use profile of pediatric magistral formulations in a public maternal and child hospital, reference in southwest Bahia (Brazil). |
P+N: Captopril, Spironolactone, Hydrochlorothiazide |
Gonçalves et al., 20172727 Gonçalves AC, Reis AM, Marçal AC, Bouzada MC. Use of unlicensed and off-label drugs in neonates in a Brazilian university hospital. Braz J Pharm Sci. 2017;53:e00252. https://doi.org/10.1590/s2175-97902017000300252 https://doi.org/10.1590/s2175-9790201700...
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Prospective study |
To investigate the use of off-label drugs in NICUs according to ANVISA and the FDA |
NICU: Amiodarone, Captopril, Carvedilol, Spironolactone, Furosemide, Hydrochlorothiazide, Nifedipine |
Pereira et al., 20162828 Pereira AC, Miranda ES, Castilho SR, Futuro DO, Teixeira LA, Paula GR. Magistral drugs in hospitalized newborns and children. Rev Paul Pediatr. 2016;34:403-7. https://doi.org/10.1016/j.rpped.2016.02.002 https://doi.org/10.1016/j.rpped.2016.02....
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Descriptive study |
To study the use of magisterial oral solutions and suspensions in newborns and children at a university hospital |
P+N: Amiodarone, Captopril, Enalapril, Spironolactone, Furosemide, Hydralazine, Hydrochlorothiazide, Propranolol |
Souza Junior et al., 20162929 Souza Junior AS, Santos DB, Rey LC, Medeiros MG, Vieira MG, Coelho HL. Off-label use and harmful potential of drugs in a NICU in Brazil: a descriptive study. BMC Pediatr. 2016;16:13. https://doi.org/10.1186/s12887-016-0551-8 https://doi.org/10.1186/s12887-016-0551-...
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Retrospective cohort study |
To describe the drugs prescribed for different groups of neonates admitted to the NICU and to analyze the off-label use and the harmful potential of the drugs |
NICU: Spironolactone, Captopril, Furosemide, Propranolol, Epinephrine (the type of transformation is not mentioned in the study) |
Dos Santos et al., 20123030 Dos Santos L, Heineck I. Drug utilization study in pediatric prescriptions of a university hospital in southern Brazil: off-label, unlicensed and high-alert medications. Farm Hosp. 2012;36:180-6. https://doi.org/10.1016/j.farma.2010.12.008 https://doi.org/10.1016/j.farma.2010.12....
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Cross-sectional study |
To describe and determine the extent of use of unlicensed, off-label, and high-risk drugs in the general pediatric units of a university hospital in southern Brazil |
P+N: Spironolactone, Furosemide |
Ferreira et al., 20123131 Ferreira AL, Ibiapina CC, Machado MG, Fagundes ED. High prevalence of off-label and unlicensed drug prescribing in a Brazilian intensive care unit. Rev Assoc Med Bras (1992). 2012;58:82-7. https://doi.org/10.1016/S2255-4823(12)70159-5 https://doi.org/10.1016/S2255-4823(12)70...
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Cross-sectional study |
To describe the use and determine the prescription prevalence of off-label and unlicensed medicines in a pediatric intensive care unit of a hospital in southeastern Brazil |
P+N: Captopril, Furosemide, Hydrochlorothiazide |
Costa et al., 200933 Costa PQ, Lima JE, Coelho HL. Prescrição e preparo de medicamentos sem formulação adequada para crianças: um estudo de base hospitalar. Braz J Pharm Sci. 2009;45:57-66. https://doi.org/10.1590/S1984-82502009000100007 https://doi.org/10.1590/S1984-8250200900...
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Descriptive study |
To identify drugs whose dosage form or formulation represents a problem in pediatrics (problem medication) |
P+N: Captopril, Digoxin, Spironolactone, Furosemide, Hydrochlorothiazide, Nifedipine |
Costa et al., 20093232 Costa PQ, Rey LC, Coelho HL. Lack of drug preparations for use in children in Brazil. J Pediatr. 2009;85:229-35. https://doi.org/10.2223/JPED.1896 https://doi.org/10.2223/JPED.1896...
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Descriptive study |
To identify drugs that present difficulties for their pediatric use in Brazil |
P+N: Captopril, Spironolactone, Hydrochlorothiazide, Propranolol |