In this article, we provide a picture of the so-called natural history of the Kline-Levin syndrome by means of a critical review and discussion of the scientific literature published so far about this topic. We focused special attention on the psychiatric correlates of this neuropsychiatric syndrome, addressing the diagnostic dilemmas raised from them. We also discuss the difficulties and show the profile that the knowledge about the state of the art in this area allows us to outline for the natural history of this syndrome.
Kleine-Levin syndrome; natural history; clinical frame; clinical course