Human immune responses during schistosomiasis mansoni

Gazzinelli, Giovanni; Colley, Daniel G.

doi:10.1590/S0037-86821992000200006

Abstracts

Studies of immune responses as they occur in patients with schistosomiasis appear to progress relative to corrent technological advances, and to advance despite the understandable inability to pursue in vivo manipulations in this host/parasite system. Emphasis is most often placed on making immunological comparisons between such patient groups as reinfected/non-reinfected, intestinals/hepatosplenic, high/low intensities of infection, infected/uninfected within endemic areas, and those born of infected/uninfected mothers. Based on these types of comparisons, reasonable conjectures can be made regarding the immunological occurrences during this chronic exposure condition. Some consideration is now being given to the immune mechanisms of some of the observations made, and while some of these must then be carried back to experimental models for further manipulation-based analysis, new technological developments continue to assist in the field/bench ability to ask questions that might assist our understanding to a point where this knowledge can be applied to shaping developmental approaches to vaccine development and the goal of alleviating morbidity.

Schistosomiasis; Immune responses; Immunoregulation

O estudo da resposta imune de pacientes com esquistossomose progride em função do avanço tecnológico, apesar das dificuldades de manipulação in vivo deste complexo sistema parasita-hospedeiro. A ênfase nos estudos tem sido mais freqüentemente dirigida para comparações entre grupos característicos de indivíduos, tais como infectado/não infectado, reinfectado/ não reinfectado, assintomático/hepato-esplênico, com intensidade de infecção alta/baixa, etc. Baseado nessas comparações tem-se obtido informações que permitem conjecturas razoáveis com relação à regulação imunológica, susceptibilidade e resistência e até mesmo considerações sôbre mecanismos, que têm sido mais apropriadamente analisados, entretanto, em sistemas experimentais. Tais estudos têm como finalidade a compreensão das camas e eventos que le vam à morbidade e ao desenvolvimento de uma vacina humana anti- esquistosoma.

Esquistosomíase; Resposta imune; Imuno-regulação

ARTIGO DE REVISÃO

Human immune responses during schistosomiasis mansoni

Giovanni Gazzinelli; Daniel G. Colley

ABSTRACT

Studies of immune responses as they occur in patients with schistosomiasis appear to progress relative to corrent technological advances, and to advance despite the understandable inability to pursue in vivo manipulations in this host/parasite system. Emphasis is most often placed on making immunological comparisons between such patient groups as reinfected/non-reinfected, intestinals/hepatosplenic, high/low intensities of infection, infected/uninfected within endemic areas, and those born of infected/uninfected mothers. Based on these types of comparisons, reasonable conjectures can be made regarding the immunological occurrences during this chronic exposure condition. Some consideration is now being given to the immune mechanisms of some of the observations made, and while some of these must then be carried back to experimental models for further manipulation-based analysis, new technological developments continue to assist in the field/bench ability to ask questions that might assist our understanding to a point where this knowledge can be applied to shaping developmental approaches to vaccine development and the goal of alleviating morbidity.

Keywords: Schistosomiasis. Immune responses. Immunoregulation.

RESUMO

O estudo da resposta imune de pacientes com esquistossomose progride em função do avanço tecnológico, apesar das dificuldades de manipulação in vivo deste complexo sistema parasita-hospedeiro. A ênfase nos estudos tem sido mais freqüentemente dirigida para comparações entre grupos característicos de indivíduos, tais como infectado/não infectado, reinfectado/ não reinfectado, assintomático/hepato-esplênico, com intensidade de infecção alta/baixa, etc. Baseado nessas comparações tem-se obtido informações que permitem conjecturas razoáveis com relação à regulação imunológica, susceptibilidade e resistência e até mesmo considerações sôbre mecanismos, que têm sido mais apropriadamente analisados, entretanto, em sistemas experimentais. Tais estudos têm como finalidade a compreensão das camas e eventos que le vam à morbidade e ao desenvolvimento de uma vacina humana anti- esquistosoma.

Palavras-chave: Esquistosomíase. Resposta imune. Imuno-regulação.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

59. Parra JC, LimaM, Colley TA, GazzinelliG, Colley DG. Flow cytometric analysis of schistosomal patient's lymphoblasts stimulated in vitro leg soluble antigens (SEA), anti-SEA idiotypes and staphylococcal enterotoxin B (SEB). In: Abstracts of International Symposium on Schistosomiasis. Recife p. 20-25, 1991.

Recebido para publicação em 18/12/91.

Centro de Pesquisas René Rachou (FIOCRUZ), Belo Horizonte, MG, Brazil, and the Veterans Affair Medical Center and Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37212.

Support from National Institutes of Health, UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, Conselho Nacional de Desenvolvimento Cientifico e Tecnológico do Brasil, e Fundação de Amparo'a Pesquisa de Minas Gerais (Brasil).

1. Abdel-Salam E, Abdel-Khalih A, Abdel-Meguid A, Barakut W, Mahmond AA. Association of HLA class I antigens (Al, B5, B8 and CW2) with disease manifestations and infection inhuman schistosomiasis mansoni in Egypt. Tissue Antigens 27: 142-146, 1986.
2. Abdel-Salam E, Ishaac S, Mahmoud AAF. Histocompatibility-linked susceptibility for hepatosplenomegaly in human schistosomiasis. Journal of Immunology 123: 1829-1831, 1979.
3. Abel L, Demenais F, Prata A, Souza AE, Dessein A. Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Schistosoma mansoni American Journal of Human Genetics 48: 959-970, 1991.
4. Alves-Brito CF, Simpson AJG, Bahia-Oliveira LMC, Rabello ALT, Rocha RS, Lambertucci JR, Gazzinelli G, KatzN, Correa-OliveiraR. Analysis of anti-KLH antibody in Brazilians supports its use for the diagnosis of acute schistosomiasis mansoni. Transactions of The Royal Society of Tropical Medicine and Hygiene 86:53-56, 1992.
5. Bahia-Oliveira LMG, Gazzinelli G, Eloi-Santos SM, Cunha-Melo JR, Alves-Oliveira LF, Silveira AMS, Viana IRC, Carmo J, Souza A, Correa- Oliveira R. Differential cellular reactivity to adult worm antigens of patients with different clinical forms of schistosomiasis mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 86:57-61, 1992.
6. Barsoum IS, GamilFM, Al-KhafifMA, Ramzy RM, El Alamy MA, Colley DG. Immune responses and immunoregulation during human schistosomiasis in Egypt. I. Effect of treatment on in vitro responsiveness. The American Journal of Tropical Medicine and Hygiene 31:1181-1187, 1982.
7. Boctor FN, Peter JB. lgG subclasses in human chronic schistosomiasis: over-production of scchistosome-specific and non-specific IgG4. Clinical and Experimental Immunology 82: 574- 578, 1989.
8. Butterworth AE, Corbett EL, Dunne DW, Fulford AJC, Kimani G, Gachuhi RK, Klumpp R, Mbugiia G, Ouma JH, Arap Siongok RK, Sturrock RF. Immunity and morbidity in human schistosomiasis. In: McAdam KPWJ(ed) New Strategies in Parasitology. Churchill-Livingstone,London p. 193- 210, 1989.
9. Capron M, Camus D, Carlier Y, Figueiredo JFM, Capron A. Immunological studies in human schistosomiasis. II. Antibodies cytotoxic for Schistosoma mansoni schistosomules. The American Journal of Tropical Medicine and Hygiene 26: 248- 253, 1977.
10. Cheever AW. A quantitative post-mortem study of schistosomiasis mansoni in man. The American Journal of Tropical Medicine and Hygiene 17: 38- 64, 1968.
11. Clarke VV. Evidence of the development in man of acquired resistance to infection of schistosoma spp. Central Africa Journal of Medicine 12(Suppl. I): 1- 30, 1966.
12. Colley DG. Dynamics ofthe human immune response to schsistosomes. In: Mahmoud AAFfed) Bailliere's Clinical Tropical Medicine and Communicable Diseases, Vol. 2,Schistosomiasis, Bailliere-Tindall, London 315-332, 1987.
13. Colley DG, Barsoum IS, Dahawi HSS, Gamil F, Habib M, El Alamy MA. Immune responses and immunoregulation in relation to Schistosomiasis in Egypt. III. Immunity and longitudinal studies of in vitro responsiveness after treatment. Transactions ofThe Royal Society Tropical Medicineand Hygiene 80: 952-957, 1986.
14. Colley DG, CookJ R,Freeman Jr GL,Bartholomew RK, Jordan P. Immune responses during human schistosomiasis mansoni. I. In vitro lymphocyte blastogénie responses to heterogeneous antigenic preparation from schistosome eggs, worms and cercariae. International Archives of Allergy and Applied Immunology 53: 420-443, 1977.
15. Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G. Immune responses during human schistosomiasis. XII Differential responsiveness in patients with hepatosplenic disease.The American Journal of Tropical Medicine and Hygiene 35:793-802, 1986.
16. Colley DG, Katz N, Rocha RS, Abrantes W, da Silva AL, Gazzinelli G. Immune responses during human schistosomiasis mansoni. IX. T lymphocyte subset analysis by monoclonal antibodies in hepatosplenic disease. Scandinavian Journal of Immunology 17: 297-301, 1983.
17. Colley DG, Montesano MA, Powell MR, Eloi- Santos SM, Parra JC, Goes AM, Doughty BL Correa-Oliveira R, Rocha RS , Gazzinelli G. Idiotype networks in schistosomiasis. In: Mc Adam KPWJ (ed) New strategies in Parasitology, Churchill- Livingstone, London p. 179-190, 1989.
18. Correa-Oliveira, R, DusseLMS, VianalRC, Colley DG, Carvalho OS, Gazzinelli G. Human antibody responses against schistosomal antigens. I. Antibodies from patients with ancylostoma, Ascaris lumbricoides or Schistosoma mansoni infections react with schistosome antigens. The American Journal of Tropical Medicine and Hygiene38:348-355, 1988.
19. Correa-OliveiraR, OliveiraGC, GolgherDB, Viana JRC, Colley DG, Carvalho OS, Rocha RS, Katz N, Gazzinelli G. Analysis of antibody responses of Schistosoma mansoni-infccted patients against schistosomal antigens. Memórias do Instituto Oswaldo Cruz 82 (Suppl IV): 179-181, 1987.
20. Correa-OliveiraR, PearceEJ, Oliveira GC, Golgher DB, Katz N, Bahia LG, Carvalho OS, Gazzinelli G. Thehuman immune response to defined immunogens of Schistosoma mansoni: elevated antibody levels to paramyosin in stool-negative individuals from two endemic areas in Brazil. Transactions of the Royal Society of Tropical M edicine and Hygiene 83:1205- 1209, 1989.
21. Dabes TMP, Garcia AA, Colley DG, Ramalho- Pinto FJ. Lymphokine production by blood or spleen mononuclear cells from patients with schistosomiasis mansoni. The American Journal of Tropical Medicineand Hygiene40:273-281,1989.
22. Dessein AJ, Begley M, DemeareC, CailolD, Fueri J, Galvão dos Reis M, Andrade Z, Prata A, Bina JC. Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen. Journal of Immunology 140:2727- 2736, 1988.
23. Doughty BL, Goes AM, ParraJC, Rocha RS, Cone C, Colley DG, Gazzinelli G. Anti-idiotypic T cells in human schistosomiasis. Immunological Investigation 18: 373-388, 1989.
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Publication Dates

Publication in this collection
19 Apr 2013
Date of issue
June 1992

History

Received
18 Dec 1991
Accepted
18 Dec 1991

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Abdel-Salam E, Abdel-Khalih A, Abdel-Meguid A, Barakut W, Mahmond AA. Association of HLA class I antigens (Al, B5, B8 and CW2) with disease manifestations and infection inhuman schistosomiasis mansoni in Egypt. Tissue Antigens 27: 142-146, 1986.

[2] 2. Abdel-Salam E, Ishaac S, Mahmoud AAF. Histocompatibility-linked susceptibility for hepatosplenomegaly in human schistosomiasis. Journal of Immunology 123: 1829-1831, 1979.

[3] 3. Abel L, Demenais F, Prata A, Souza AE, Dessein A. Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Schistosoma mansoni American Journal of Human Genetics 48: 959-970, 1991.

[4] 4. Alves-Brito CF, Simpson AJG, Bahia-Oliveira LMC, Rabello ALT, Rocha RS, Lambertucci JR, Gazzinelli G, KatzN, Correa-OliveiraR. Analysis of anti-KLH antibody in Brazilians supports its use for the diagnosis of acute schistosomiasis mansoni. Transactions of The Royal Society of Tropical Medicine and Hygiene 86:53-56, 1992.

[5] 5. Bahia-Oliveira LMG, Gazzinelli G, Eloi-Santos SM, Cunha-Melo JR, Alves-Oliveira LF, Silveira AMS, Viana IRC, Carmo J, Souza A, Correa- Oliveira R. Differential cellular reactivity to adult worm antigens of patients with different clinical forms of schistosomiasis mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 86:57-61, 1992.

[6] 6. Barsoum IS, GamilFM, Al-KhafifMA, Ramzy RM, El Alamy MA, Colley DG. Immune responses and immunoregulation during human schistosomiasis in Egypt. I. Effect of treatment on in vitro responsiveness. The American Journal of Tropical Medicine and Hygiene 31:1181-1187, 1982.

[7] 7. Boctor FN, Peter JB. lgG subclasses in human chronic schistosomiasis: over-production of scchistosome-specific and non-specific IgG4. Clinical and Experimental Immunology 82: 574- 578, 1989.

[8] 8. Butterworth AE, Corbett EL, Dunne DW, Fulford AJC, Kimani G, Gachuhi RK, Klumpp R, Mbugiia G, Ouma JH, Arap Siongok RK, Sturrock RF. Immunity and morbidity in human schistosomiasis. In: McAdam KPWJ(ed) New Strategies in Parasitology. Churchill-Livingstone,London p. 193- 210, 1989.

[9] 9. Capron M, Camus D, Carlier Y, Figueiredo JFM, Capron A. Immunological studies in human schistosomiasis. II. Antibodies cytotoxic for Schistosoma mansoni schistosomules. The American Journal of Tropical Medicine and Hygiene 26: 248- 253, 1977.

[10] 10. Cheever AW. A quantitative post-mortem study of schistosomiasis mansoni in man. The American Journal of Tropical Medicine and Hygiene 17: 38- 64, 1968.

[11] 11. Clarke VV. Evidence of the development in man of acquired resistance to infection of schistosoma spp. Central Africa Journal of Medicine 12(Suppl. I): 1- 30, 1966.

[12] 12. Colley DG. Dynamics ofthe human immune response to schsistosomes. In: Mahmoud AAFfed) Bailliere's Clinical Tropical Medicine and Communicable Diseases, Vol. 2,Schistosomiasis, Bailliere-Tindall, London 315-332, 1987.

[13] 13. Colley DG, Barsoum IS, Dahawi HSS, Gamil F, Habib M, El Alamy MA. Immune responses and immunoregulation in relation to Schistosomiasis in Egypt. III. Immunity and longitudinal studies of in vitro responsiveness after treatment. Transactions ofThe Royal Society Tropical Medicineand Hygiene 80: 952-957, 1986.

[14] 14. Colley DG, CookJ R,Freeman Jr GL,Bartholomew RK, Jordan P. Immune responses during human schistosomiasis mansoni. I. In vitro lymphocyte blastogénie responses to heterogeneous antigenic preparation from schistosome eggs, worms and cercariae. International Archives of Allergy and Applied Immunology 53: 420-443, 1977.

[15] 15. Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G. Immune responses during human schistosomiasis. XII Differential responsiveness in patients with hepatosplenic disease.The American Journal of Tropical Medicine and Hygiene 35:793-802, 1986.

[16] 16. Colley DG, Katz N, Rocha RS, Abrantes W, da Silva AL, Gazzinelli G. Immune responses during human schistosomiasis mansoni. IX. T lymphocyte subset analysis by monoclonal antibodies in hepatosplenic disease. Scandinavian Journal of Immunology 17: 297-301, 1983.

[17] 17. Colley DG, Montesano MA, Powell MR, Eloi- Santos SM, Parra JC, Goes AM, Doughty BL Correa-Oliveira R, Rocha RS , Gazzinelli G. Idiotype networks in schistosomiasis. In: Mc Adam KPWJ (ed) New strategies in Parasitology, Churchill- Livingstone, London p. 179-190, 1989.

[18] 18. Correa-Oliveira, R, DusseLMS, VianalRC, Colley DG, Carvalho OS, Gazzinelli G. Human antibody responses against schistosomal antigens. I. Antibodies from patients with ancylostoma, Ascaris lumbricoides or Schistosoma mansoni infections react with schistosome antigens. The American Journal of Tropical Medicine and Hygiene38:348-355, 1988.

[19] 19. Correa-OliveiraR, OliveiraGC, GolgherDB, Viana JRC, Colley DG, Carvalho OS, Rocha RS, Katz N, Gazzinelli G. Analysis of antibody responses of Schistosoma mansoni-infccted patients against schistosomal antigens. Memórias do Instituto Oswaldo Cruz 82 (Suppl IV): 179-181, 1987.

[20] 20. Correa-OliveiraR, PearceEJ, Oliveira GC, Golgher DB, Katz N, Bahia LG, Carvalho OS, Gazzinelli G. Thehuman immune response to defined immunogens of Schistosoma mansoni: elevated antibody levels to paramyosin in stool-negative individuals from two endemic areas in Brazil. Transactions of the Royal Society of Tropical M edicine and Hygiene 83:1205- 1209, 1989.

[21] 21. Dabes TMP, Garcia AA, Colley DG, Ramalho- Pinto FJ. Lymphokine production by blood or spleen mononuclear cells from patients with schistosomiasis mansoni. The American Journal of Tropical Medicineand Hygiene40:273-281,1989.

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