Introduction:
We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria.
Methods:
A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate antimalarial activity.
Results:
The geometric-mean 50% effective concentration (EC50%) of tigecycline was 535.5 nM (confidence interval (CI): 344.3-726.8). No significant correlation was found between the EC50% of tigecycline and that of any other tested antimalarial drug.
Conclusions:
Tigecycline may represent an alternative drug for the treatment of patients with severe malaria.
Plasmodium falciparum ; In vitro susceptibility; Tigecycline