Coumaric acid analogues + amphotericin B
|
Checkerboard assays |
114
114. Oliveira L, Ferrarini M, dos Santos AP, Varela MT, Corrêa ITS, Tempone AG, et al. Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity. Eur J Pharm Sci. 2020;153:105473.
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Artovastatin + fluconazole
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Checkerboard assays |
120
120. Ribeiro N de Q, Costa MC, Magalhães TFF, Carneiro HCS, Oliveira LV, Fontes ACL, et al. Atorvastatin as a promising anticryptococcal agent. Int J Antimicrob Agents. 2017;49(6):695-702.
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Curcumin + amphotericin B
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Checkerboard assays |
134
134. da Silva DL, Magalhães TFF, dos Santos JRA, de Paula TP, Modolo L V, de Fátima A, et al. Curcumin enhances the activity of fluconazole against Cryptococcus gattii-induced cryptococcosis infection in mice. J Appl Microbiol. 2016;120(1):41-8.
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Dicyclomine + fluconazole
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Virtual library |
135
135. Wambaugh MA, Denham ST, Ayala M, Brammer B, Stonhill MA, Brown JCS. Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections. Elife. 2020;9:e54160.
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Duloxetine + fluconazole
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Checkerboard assays |
136
136. Menezes RT, Pereira TC, Junqueira JC, Oliveira LD, Scorzoni L. Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans. An Acad Bras Cienc. 2022;94(2):1-7.
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Erythromycin + amphotericin B
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Virtual library |
37
37. Rossi SA, De Oliveira HC, Agreda-Mellon D, Lucio J, Soares Mendes-Giannini MJ, García-Cambero JP, et al. Identification of off-patent drugs that show synergism with amphotericin B or that present antifungal action against Cryptococcus neoformans and Candida spp. Antimicrob Agents Chemother. 2020;64(4):1-16.
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Fluoxetine + amphotericin B
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Checkerboard assays |
137
137. Pereira TC, De Menezes RT, De Oliveira HC, De Oliveira LD, Scorzoni L. In vitro synergistic effects of fluoxetine and paroxetine in combination with amphotericin B against Cryptococcus neoformans. Pathog Dis. 2021;79(2):1-9.
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Glimepiride+ amphotericin B
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Virtual library |
37
37. Rossi SA, De Oliveira HC, Agreda-Mellon D, Lucio J, Soares Mendes-Giannini MJ, García-Cambero JP, et al. Identification of off-patent drugs that show synergism with amphotericin B or that present antifungal action against Cryptococcus neoformans and Candida spp. Antimicrob Agents Chemother. 2020;64(4):1-16.
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Lactoferrin + amphotericin B
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Checkerboard assays |
138
138. Fernandes KE, Weeks K, Carter DA. Lactoferrin is broadly active against yeasts and highly synergistic with amphotericin B. Antimicrob Agents Chemother . 2020;64(5):1-22.
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Minocycline + fluconazole
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Checkerboard assays |
10
10. Kong Q, Cao Z, Lv N, Zhang H, Liu Y, Hu L, et al. Minocycline and fluconazole have a synergistic effect Against Cryptococcus neoformans Both in vitro and in vivo. Front Microbiol. 2020;11(05):1-11.
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N-acetylcysteine + amphotericin B
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Checkerboard assays |
139
139. Ferreira Magalhães TF, Costa MC, Holanda RA, Ferreira GF, Dutra Carvalho VS, Cota Freitas GJ, et al. N-acetylcysteine reduces amphotericin B deoxycholate nephrotoxicity and improves the outcome of murine cryptococcosis. Med Mycol. 2021;58(6):835-44.
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Simvastatin + amphotericin B
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Checkerboard assays |
140
140. Silva THS, Araújo CV, Santos KM da C, Alves NDS, Gomes THS, E Silva AKF, et al. Synergic effect of simvastatin in combination with amphotericin b against environmental strains of cryptococcus neoformans from northeastern brazil: A prospective experimental study. Sao Paulo Med. J 2020;138(1):40-6.
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Tamoxifen + amphotericin B
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Checkerboard assays |
117
117. Hai TP, Van AD, Ngan NTT, Nhat LTH, Lan NPH, Vinh Chau N V, et al. The combination of tamoxifen with amphotericin B, but not with fluconazole, has synergistic activity against the majority of clinical isolates of Cryptococcus neoformans. Mycoses. 2019;62(9):818-25.
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Triclosan + fluconazole
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Checkerboard assays |
141
141. Movahed E, Yi Tan GM, Munusamy K, Yeow TC, Tay ST, Wong WF, et al. Triclosan demonstrates synergic effect with amphotericin B and fluconazole and induces apoptosis-like cell death in Cryptococcus neoformans. Front Microbiol. 2016;7:360.
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Pedalitin + amphotericin B
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Checkerboard assays |
142
142. Sangalli-Leite F, Scorzoni L, Alves de Paula e Silva AC, da Silva J de F, de Oliveira HC, de Lacorte Singulani J, et al. Synergistic effect of pedalitin and amphotericin B against Cryptococcus neoformans by in vitro and in vivo evaluation. Int J Antimicrob Agents . 2016;48(5):504-11.
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α -Cyperone + fluconazole
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Checkerboard assays |
143
143. Horn C, Vediyappan G. Anticapsular and antifungal activity of α-cyperone. Antibiotics. 2021;10(1):1-10.
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