Expression of co-stimulatory molecules CD80 and CD86 is altered in CD14 ⁺ HLA-DR ⁺ monocytes from patients with Chagas disease following induction by Trypanosoma cruzi recombinant antigens

Abstract

INTRODUCTION

The relationships between monocytes and lymphocytes through MHC class II molecules and costimulatory, are of utmost importance for the production of an efficient immune response. In this work, we assessed the expression of surface molecules CD80 and CD86 on CD14⁺HLA-DR⁺ monocytes from patients with Chagas disease.

METHODS:

The study population consisted of 31 patients with chronic clinical forms of Chagas disease. Patient blood samples were cultured in the presence of recombinant cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA).

RESULTS:

We found considerable differences in the expression profile of surface molecules involved in antigen presentation.

CONCLUSIONS:

CRA and FRA may contribute to host immune response evasion by Trypanozoma cruzi.

Keywords:
Chagas disease; Immune response; Recombinant antigens