During the period October 1992 to July 1995 we measured the osmolarity and pH of ampoules of meglumina antimoniato (glucantime®) from lot 9206L-004 (matiufacturated by Rhodia Farma Ltd, of São Paulo, SP, Brazil) mantained in three temperature conditions namely 4ºC, 37ºC and ambiental. Although we observed statistically significant differences in osmolarity between samples, the limited number of measurements and the variation of this property in ampoles mantained at the same temperature were obstacles to obtain definitive conclusions. Such a variation was not found with pH. Assuming these parameters could reflect structural changes in the pentavalent antimony molecule, clearly further better controlled experiments are indicated.
Pentavalent antimonial; Osmolarity; pH; Tempera ture of storage