During a three year period from 1967- 1970, the Author studied twenty two cases of acquired toxoplasmosis (glandular form). The case-hystory consisted of diffuse lymphadenopathy, usually in the neck, fever, fatigue, anorexia, headache, dizziness, muscle pain, hepatosplenomegaly, and lymphocytosis. The clinical diagnosis was confirmed by strongly positive serologic reaction (Sabin-Feldman 'dye test'), and in one case by isolation of Toxoplasma gondii from the peritoneal exudate of mice, experimentally inoculated with lymph-node fluid. The glandular material tvas obtained by punction of enlarged cervical lymphnode. A lymph-node biopsy specimen revealed reticuloendothelial hyperplasia with eosinophilic cytoplasm. All patients had negative Paul-Bunnell reaction. The patients loere treated with Spyramicm and Sulfametoxyprimidine, or spyramicin isolated in a few capes.