Here, we present four patients with confirmed Chikungunya virus infection showing atypical neurologic manifestations and death. This case series includes patients ranging in age from five to 92 years, with or without comorbidities. This report is important, as very few cases in the literature reporting death due to atypical Chikungunya virus infection are available.
Keywords:
Chikungunya fever; Neurologic manifestations; Death
| Cases | Sex | Age (years) | Comorbidity | Leukocytes | Lymphocytes | Ionogram (mEq/L) | Urea | Creatinine (mg/dL) | CSF | CT Scan | Serology |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient 1 | M | 5 | No | 5,700 | 456 | Na 157 K 3.7 | 20 | 1 | Not analyzed | Diffuse cerebral edema | IgM + Chikungunya; NS1 negative dengue. |
| Patient 2 | F | 51 | DM | 20,100 (16% band cells) | 1,800 | Na 151 K 3.5 | 92 | 0.9 | Leukocytes: 113 (90% lymphocytes) Glucose: 269mg/dL Proteins: 291 mg/dL | Slight thickening of thoracic segment of the spinal cord and small collections/abscesses in the right iliopsoas muscles, measuring 3.0 x 2.0 cm in its major axis. | IgM + Chikungunya; IgM negative dengue. |
| Patient 3 | M | 65 | DM and alcoholism | 12,100 (20% band cells) | 726 | Na 154 K 3.1 | 134 | 2.9 | Leukocytes: 4 Glucose: 327mg/dL Proteins: 57.5mg/dL | Bilateral frontal hypoattenuation | IgM + Chikungunya; IgM negative dengue. |
| Patient 4 | Fe | 92 | No | 15,900 (5% band cells) | 954 | Na 123 K 4.1 | 27 | 1.1 | Not analyzed | No acute alterations | IgM + Chikungunya; IgM negative dengue. |
