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Short Communications • Rev. Soc. Bras. Med. Trop. 49 (06) • Nov-Dec 2016 • https://doi.org/10.1590/0037-8682-0141-2016   copy

There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis.

METHODS:

This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression.

RESULTS:

There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment.

CONCLUSIONS:

There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.

Keywords:
Interleukin-10; Periportal fibrosis; Schistosomiasis mansoni

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