Antiplasmodial and antileishmanial activities of compounds from <i>Piper tuberculatum</i> Jacq fruits

Oliveira, Flávio Augusto de Souza; Passarini, Guilherme Matos; Medeiros, Daniel Sol Sol de; Santos, Ana Paula de Azevedo; Fialho, Saara Neri; Gouveia, Aurileya de Jesus; Latorre, Marcinete; Freitag, Elci Marlei; Medeiros, Patrícia Soares de Maria de; Teles, Carolina Bioni Garcia; Facundo, Valdir Alves

doi:10.1590/0037-8682-0309-2017

Acessibilidade / Reportar erro

Brasil

Revista da Sociedade Brasileira de Medicina Tropical

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Short Communication • Rev. Soc. Bras. Med. Trop. 51 (03) • May-Jun 2018 • https://doi.org/10.1590/0037-8682-0309-2017 copy

Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION

This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis.

METHODS

The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured.

RESULTS

Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity.

CONCLUSIONS

The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.

Keywords:
Malaria; Leishmaniasis; Piper; Bioactivity

Compounds	P. falciparum IC ₅₀	HepG2 CC₅₀	SI
	(µg/mL) ± SD	(µg/mL) ± SD
PTFCE	≥ 100	40.5 ± 9.8	≤ 0.4
PTFHF	10.72 ± 0.3	23.05 ± 4.5	2.1
PTFCF	9.81 ± 1.9	≥ 100	≥ 10.2
PTFEAF	34.9 ± 0.2	≥ 100	≥ 2.9
PTFMF	46.46 ± 2.6	≥ 100	≥ 2.1
HF-1	20.86 ± 3.8	≥ 100	≥ 4.8
HF-2	≥ 100	30.42 ± 6.7	≤ 0.3
HF-3	16.26 ± 3.2	≥ 100	≥ 6.1
HF-4	≥ 100	6.75 ± 5.1	≤ 0.06
HF-5	7.03 ± 1.2	≥ 100	14.2
HF-7	4.13 ± 0.3	7.2 ± 0.8	1.7
Pellitorine	21.8 ± 1.7	≥ 100	≥ 4.6
Artemisinin	0.0026 ± 0.4	≥ 1,000	≥ 384.6

Compounds	L. guyanensis IC ₅₀ (µg/mL) ± SD	J774 CC₅₀	SI
		(µg/mL) ± SD
PTFCE	≥ 100	63.2 ± 5.2	≤ 1.58
PTFHF	93.89 ± 8.4	≥ 100	≥ 1.06
PTFCF	19.98 ± 1.3	4.2 ± 1.3	0.21
PTFEAF	≥ 100	48.94 ± 0.9	≤ 0.48
PTFMF	≥ 100	≥ 100	---
HF-1	≥ 100	≥ 100	---
HF-2	14.4 ± 0.7	75.77 ± 0.1	5.26
HF-3	≥ 100	≥ 100	---
HF-4	10.15 ± 1.9	3.8 ± 0.9	0.37
HF-5	≥ 100	≥ 100	---
HF-7	2.75 ± 0.5	1.6 ± 0.07	0.58
Pellitorin	26.84 ± 9.4	67.8 ± 9.3	2.52
Pentamidine	0.87 ± 0.8	6.13 ± 0.9	7.04

Sociedade Brasileira de Medicina Tropical - SBMT Caixa Postal 118, 38001-970 Uberaba MG Brazil, Tel.: +55 34 3318-5255 / +55 34 3318-5636/ +55 34 3318-5287, http://rsbmt.org.br/ - Uberaba - MG - Brazil
E-mail: rsbmt@uftm.edu.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Corresponding author: Msc Guilherme Matos Passarini e-mail: guilhermepassarini@hotmail.com