Buschke-Lowenstein tumor in a woman living with HIV/AIDS

Araújo, Paulo Sérgio Ramos de; Padilha, Carlos Eduardo Guimarães; Soares, Melina Ferraz

doi:10.1590/0037-8682-0396-2016

A 32-year-old woman presented with an 8-month history of verrucous and suppurative skin lesions on the anogenital area. She was diagnosed with human immunodeficiency virus (HIV) infection 18 months before and was receiving antiretroviral therapy thereafter. She underwent excision and experienced recurrence of perineal warts since the age of 28 years. Clinical examination showed oval hyperchromic keratotic plaques on the perineum, and extensive verrucous masses located on the left buttock that were painful to touch, friable, and foul-smelling, with some bleeding and purulent exudate on the surface (Figure A). The cluster of differentiation 4 (CD4) count was 219 cells/mm³ and the HIV viral load was undetectable. Pelvic magnetic resonance revealed confluent fluid collections, with edema of the gluteal muscles and fistulous communication between collections and the intersphincteric region of the anal canal. Deep biopsy of one of the multiple exophytic lesions was performed. Microscopic examination revealed a verrucous architecture, papillomatosis, parakeratosis, hyperkeratosis, and koilocytotic changes with an intact basement membrane. These findings were consistent with verrucous carcinoma (VC) or a Buschke-Lowenstein tumor (BLT). BLT is a rare disease triggered by HPV, usually subtypes 6/11. Clinical manifestations typically include a palpable mass, pain, bleeding, fistulas, or pruritus¹. Immunodeficiency is a significant risk factor, and the histological features of BLT are very similar to those of VC; some authors do not differentiate between these diseases²^,³. Although locally aggressive and destructive in appearance, BLT has low metastatic potential³.

FIGURE A
Vegetative formations that are erythematous, exophytic, and friable in the left buttock.

Acknowledgments

We thank the institutions for technical cooperation.

REFERENCES

¹ Spînu D, Rădulescu A, Bratu O, Checherită IA, Ranetti AE, Mischianu D. Giant condyloma acuminatum - Buschke-Lowenstein disease - a literature review. Chirurgia. 2014;109(4):445-50.
² Virgilio E, Balducci G, Mercantini P, Tozzi F, Ziparo V, Ferri M. Perianal giant condyloma acuminatum of Buschke-Loewenstein: a carcinoma-like condyloma or a condyloma-like carcinoma? ANZ J Surg. 2015;85(5):394-5.
³ Ahsaini M, Tahiri Y, Tazi MF, Elammari J, Mellas S, Khallouk A, et al. Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke-Lowenstein tumor): a case report and review of the literature. J Med Case Rep. 2013;7:273.

Financial support : Universidade Federal de Pernambuco, Hospital de Clínicas.

Publication Dates

Publication in this collection
Jul-Aug 2017

History

Received
22 Sept 2016
Accepted
08 Nov 2016

This is an open-access article distributed under the terms of the Creative Commons Attribution License

[1] ¹ Spînu D, Rădulescu A, Bratu O, Checherită IA, Ranetti AE, Mischianu D. Giant condyloma acuminatum - Buschke-Lowenstein disease - a literature review. Chirurgia. 2014;109(4):445-50.

[2] ² Virgilio E, Balducci G, Mercantini P, Tozzi F, Ziparo V, Ferri M. Perianal giant condyloma acuminatum of Buschke-Loewenstein: a carcinoma-like condyloma or a condyloma-like carcinoma? ANZ J Surg. 2015;85(5):394-5.

[3] ³ Ahsaini M, Tahiri Y, Tazi MF, Elammari J, Mellas S, Khallouk A, et al. Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke-Lowenstein tumor): a case report and review of the literature. J Med Case Rep. 2013;7:273.